SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 4h4a MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Drosophila
melanogaster) 		5 / 9 ALA A 103
ILE A 123
ILE A 174
ILE A  96
ILE A 100
 None
 0.95A 1hshB-4h4aA:
undetectable		 1hshB-4h4aA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 4h4a MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Drosophila
melanogaster) 		5 / 12 ALA A 103
ILE A 123
ILE A 174
ILE A  96
ILE A 100
 None
 0.94A 1hshC-4h4aA:
undetectable		 1hshC-4h4aA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 4h4a MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Drosophila
melanogaster) 		5 / 11 MET A 151
LEU A 109
LYS A 171
ILE A 111
VAL A  93
 None
 1.28A 2qd3A-4h4aA:
undetectable		 2qd3A-4h4aA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 4h4a MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Drosophila
melanogaster) 		3 / 3 LYS A 194
ARG A 185
VAL A 181
 None
 0.97A 2r2vC-4h4aA:
undetectable
2r2vD-4h4aA:
undetectable		 2r2vC-4h4aA:
15.89
2r2vD-4h4aA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4h4a MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Drosophila
melanogaster) 		5 / 12 MET A 151
LEU A 109
LYS A 171
ILE A 111
VAL A  93
 None
 1.29A 4f4dA-4h4aA:
undetectable		 4f4dA-4h4aA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 4h4a MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Drosophila
melanogaster) 		4 / 4 GLY A 177
ASP A 176
ARG A 180
MET A 168
 None
 1.36A 5zrfA-4h4aA:
undetectable		 5zrfA-4h4aA:
12.69