SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h4f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 4h4f CHYMOTRYPSIN-C
(Homo
sapiens) 		4 / 8 HIS A  57
SER A 195
VAL A 213
GLY A 216
 None
 0.63A 1aq7A-4h4fA:
36.4		 1aq7A-4h4fA:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4h4f CHYMOTRYPSIN-C
(Homo
sapiens) 		5 / 12 HIS A  57
LEU A  99
SER A 195
VAL A 213
GLY A 216
 None
 0.59A 1etrH-4h4fA:
34.4		 1etrH-4h4fA:
34.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4h4f CHYMOTRYPSIN-C
(Homo
sapiens) 		4 / 6 GLY A 142
GLN A 156
VAL A 138
ALA A 190
 None
 0.70A 1p6kA-4h4fA:
undetectable		 1p6kA-4h4fA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4h4f CHYMOTRYPSIN-C
(Homo
sapiens) 		5 / 12 GLY A  44
GLY A 196
GLY A 211
ILE A  31
VAL A  52
 None
 0.98A 2oxtC-4h4fA:
undetectable		 2oxtC-4h4fA:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4h4f CHYMOTRYPSIN-C
(Homo
sapiens) 		5 / 12 ALA A 190
SER A 195
VAL A 213
GLY A 216
TYR A 228
 None
 0.36A 2p16A-4h4fA:
35.8		 2p16A-4h4fA:
34.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 4h4f CHYMOTRYPSIN-C
(Homo
sapiens) 		5 / 12 ALA A 190
SER A 195
VAL A 213
GLY A 216
TYR A 228
 None
 0.30A 2w26A-4h4fA:
35.8		 2w26A-4h4fA:
34.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 4h4f CHYMOTRYPSIN-C
(Homo
sapiens) 		4 / 7 VAL A  90
ILE A 212
GLY A 211
ARG A 230
 None
 0.75A 3bjwB-4h4fA:
undetectable		 3bjwB-4h4fA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4h4f CHYMOTRYPSIN-C
(Homo
sapiens) 		4 / 7 VAL A  90
ILE A 212
GLY A 211
ARG A 230
 None
 0.80A 3bjwH-4h4fA:
undetectable		 3bjwH-4h4fA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 4h4f CHYMOTRYPSIN-C
(Homo
sapiens) 		4 / 8 LEU A 159
ILE A 188
ASN A 221
GLY A 187
 None
 0.83A 3wxoA-4h4fA:
undetectable		 3wxoA-4h4fA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4h4f CHYMOTRYPSIN-C
(Homo
sapiens) 		5 / 10 LEU A  53
ILE A 106
ILE A 212
GLY A 196
GLY A  43
 None
 1.03A 4fakA-4h4fA:
undetectable		 4fakA-4h4fA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4h4f CHYMOTRYPSIN-C
(Homo
sapiens) 		5 / 10 LEU A  53
ILE A 106
ILE A 212
GLY A 197
GLY A  43
 None
 0.95A 4fakA-4h4fA:
undetectable		 4fakA-4h4fA:
18.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 4h4f CHYMOTRYPSIN-C
(Homo
sapiens) 		5 / 12 HIS A  57
LEU A  99
ALA A 190
VAL A 213
GLY A 216
 None
 0.72A 4rn6B-4h4fA:
28.6		 4rn6B-4h4fA:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_A_LVYA151_1
(CEREBLON ISOFORM 4)		 4h4f CHYMOTRYPSIN-C
(Homo
sapiens) 		4 / 7 ASN A 200
PRO A 198
TRP A  27
TRP A 207
 None
 1.48A 4v30A-4h4fA:
undetectable		 4v30A-4h4fA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 4h4f CHYMOTRYPSIN-C
(Homo
sapiens) 		6 / 12 GLY A 142
GLY A  44
GLY A 197
GLY A 193
VAL A  52
ILE A  31
 None
 1.29A 5eiwC-4h4fA:
undetectable		 5eiwC-4h4fA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4h4f CHYMOTRYPSIN-C
(Homo
sapiens) 		5 / 12 LEU A  53
ILE A 106
ILE A 212
GLY A 197
GLY A  43
 None
 0.92A 5twjA-4h4fA:
undetectable		 5twjA-4h4fA:
19.69