SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 8 GLU A 250
ILE A 224
THR A 212
PRO A 243
LEU A 210
 None
 1.49A 1hmyA-4h59A:
undetectable		 1hmyA-4h59A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 182
LEU A  72
ILE A 322
LEU A 130
VAL A  58
 None
 1.19A 1hrkA-4h59A:
undetectable		 1hrkA-4h59A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 182
LEU A  72
ILE A 322
PRO A  76
VAL A  58
 None
 1.37A 1hrkB-4h59A:
undetectable		 1hrkB-4h59A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 THR A 137
GLY A 115
ASP A 112
ALA A  62
 None
None
None
CL  A 403 ( 4.1A)
 1.22A 1sg9A-4h59A:
3.3		 1sg9A-4h59A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 182
LEU A  72
ILE A 322
LEU A 130
VAL A  58
 None
 1.20A 2hrcA-4h59A:
undetectable		 2hrcA-4h59A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 182
LEU A  72
ILE A 322
LEU A 130
VAL A  58
 None
 1.24A 2hrcB-4h59A:
undetectable		 2hrcB-4h59A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 182
LEU A  72
ILE A 322
PRO A  76
VAL A  58
 None
 1.28A 2pnjB-4h59A:
undetectable		 2pnjB-4h59A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 182
LEU A  72
ILE A 322
LEU A 130
VAL A  58
 None
 1.11A 2po5A-4h59A:
undetectable		 2po5A-4h59A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 182
LEU A  72
ILE A 322
LEU A 130
VAL A  58
 None
 1.17A 2po7A-4h59A:
2.2		 2po7A-4h59A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 182
LEU A  72
ILE A 322
LEU A 130
VAL A  58
 None
 1.19A 2po7B-4h59A:
undetectable		 2po7B-4h59A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 LEU A 161
PRO A 317
LEU A 238
LEU A 235
 None
 0.92A 3q1eA-4h59A:
undetectable
3q1eC-4h59A:
undetectable		 3q1eA-4h59A:
15.64
3q1eC-4h59A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 LEU A 238
LEU A 235
LEU A 161
PRO A 317
 None
 1.00A 3q1eA-4h59A:
undetectable
3q1eC-4h59A:
undetectable		 3q1eA-4h59A:
15.64
3q1eC-4h59A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ASP A  67
LEU A 320
ILE A  74
PRO A  76
 None
 1.23A 3s3vA-4h59A:
undetectable		 3s3vA-4h59A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 TRP A  63
TRP A  95
THR A  96
 B3P  A 401 ( 3.9A)
None
None
 1.17A 4bboB-4h59A:
undetectable		 4bboB-4h59A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 MET A 175
ILE A  74
LEU A 320
LEU A  72
LEU A 130
 None
 1.36A 4m11A-4h59A:
undetectable		 4m11A-4h59A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 THR A  60
HIS A  66
LEU A  70
SER A 124
 None
 1.10A 4pfjA-4h59A:
3.3		 4pfjA-4h59A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ALA A  45
PHE A  46
ASN A  65
ILE A  61
GLY A 132
 None
 1.16A 4r20B-4h59A:
undetectable		 4r20B-4h59A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ILE A 136
PHE A  79
SER A 145
ASP A 169
 None
 1.17A 4rzvB-4h59A:
undetectable		 4rzvB-4h59A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ILE A 121
PHE A 110
GLY A  78
ILE A 129
ALA A 148
 None
 1.30A 4yp2B-4h59A:
undetectable		 4yp2B-4h59A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ILE A 121
PHE A 110
GLY A  78
ILE A 129
ALA A 148
 None
 1.32A 5cf9B-4h59A:
undetectable		 5cf9B-4h59A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ASP A 288
LEU A 291
GLY A 292
ILE A 214
ALA A 216
 None
 1.08A 5j7wD-4h59A:
undetectable		 5j7wD-4h59A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 HIS A  66
ASN A 117
ALA A 120
ASP A 140
ILE A 136
 None
GOL  A 402 (-3.4A)
GOL  A 402 ( 3.9A)
None
None
 1.10A 6b3bA-4h59A:
undetectable		 6b3bA-4h59A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 THR A 212
CYH A 315
TYR A 276
LEU A 235
 None
 1.44A 6cnjD-4h59A:
undetectable
6cnjE-4h59A:
undetectable		 6cnjD-4h59A:
15.31
6cnjE-4h59A:
14.09