SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_A_RIOA500_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4h5b DR_1245 PROTEIN
(Deinococcus
radiodurans) 		5 / 9 ASP A  52
GLU A  26
GLY A  29
SER A  49
ASP A   9
 None
 1.31A 1m4gA-4h5bA:
undetectable		 1m4gA-4h5bA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4h5b DR_1245 PROTEIN
(Deinococcus
radiodurans) 		5 / 9 ASP A  52
GLU A  26
GLY A  29
SER A  49
ASP A   9
 None
 1.28A 1m4gB-4h5bA:
undetectable		 1m4gB-4h5bA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 4h5b DR_1245 PROTEIN
(Deinococcus
radiodurans) 		4 / 5 GLU A 113
THR A 110
LEU A   6
LEU A 111
 None
 1.04A 1u18B-4h5bA:
undetectable		 1u18B-4h5bA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4h5b DR_1245 PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ILE A  24
GLN A 152
PHE A 119
VAL A 126
ILE A  62
 None
 1.21A 3em0B-4h5bA:
3.1		 3em0B-4h5bA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 4h5b DR_1245 PROTEIN
(Deinococcus
radiodurans) 		4 / 5 GLU A 138
GLY A  42
TYR A 140
GLU A  40
 None
 1.40A 3w9tA-4h5bA:
undetectable		 3w9tA-4h5bA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4h5b DR_1245 PROTEIN
(Deinococcus
radiodurans) 		4 / 5 GLU A 138
GLY A  42
TYR A 140
GLU A  40
 None
 1.40A 3w9tC-4h5bA:
undetectable		 3w9tC-4h5bA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 4h5b DR_1245 PROTEIN
(Deinococcus
radiodurans) 		4 / 5 GLU A 138
GLY A  42
TYR A 140
GLU A  40
 None
 1.39A 3w9tD-4h5bA:
undetectable		 3w9tD-4h5bA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 4h5b DR_1245 PROTEIN
(Deinococcus
radiodurans) 		4 / 5 GLU A 138
GLY A  42
TYR A 140
GLU A  40
 None
 1.39A 3w9tG-4h5bA:
undetectable		 3w9tG-4h5bA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4h5b DR_1245 PROTEIN
(Deinococcus
radiodurans) 		4 / 6 LYS A  68
LEU A 137
GLU A 138
TYR A 134
 None
 1.39A 4z4cA-4h5bA:
undetectable		 4z4cA-4h5bA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4h5b DR_1245 PROTEIN
(Deinococcus
radiodurans) 		4 / 5 LYS A  68
LEU A 137
GLU A 138
TYR A 134
 None
 1.32A 4z4hA-4h5bA:
undetectable		 4z4hA-4h5bA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4h5b DR_1245 PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A 102
ASP A 120
PHE A 123
TYR A 104
VAL A  46
 None
 1.37A 5d0yA-4h5bA:
undetectable		 5d0yA-4h5bA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_B_FOLB201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4h5b DR_1245 PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU A 102
ASP A 120
PHE A 123
TYR A 104
VAL A  46
 None
 1.37A 5d0yB-4h5bA:
undetectable		 5d0yB-4h5bA:
21.95