SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h5g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4h5g AMINO ACID ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 SER A 236
LEU A 105
VAL A 107
ALA A 112
ALA A 229
 ACT  A 305 ( 4.6A)
None
None
None
None
 1.17A 1q23A-4h5gA:
undetectable
1q23B-4h5gA:
undetectable		 1q23A-4h5gA:
20.54
1q23B-4h5gA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 4h5g AMINO ACID ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 LEU A 260
ALA A  68
GLU A  54
SER A 205
LEU A 204
 None
None
ARG  A 310 (-3.9A)
None
None
 1.07A 2bxeB-4h5gA:
undetectable		 2bxeB-4h5gA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 4h5g AMINO ACID ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A  95
GLY A 109
ALA A 108
ILE A  86
VAL A  94
 GOL  A 306 ( 4.3A)
ARG  A 310 (-4.7A)
ARG  A 310 (-3.9A)
None
None
 0.90A 2nnkA-4h5gA:
undetectable		 2nnkA-4h5gA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4h5g AMINO ACID ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 SER A 236
ASP A 121
ASP A 104
 ACT  A 305 ( 4.6A)
None
EDO  A 308 (-4.0A)
 0.82A 3iv6A-4h5gA:
undetectable		 3iv6A-4h5gA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 4h5g AMINO ACID ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 GLU A  79
VAL A 246
LEU A 250
TYR A 259
 EDO  A 309 (-3.5A)
None
None
None
 1.06A 3qeoB-4h5gA:
undetectable		 3qeoB-4h5gA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h5g AMINO ACID ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 ILE A 110
ASN A 129
ILE A 131
TYR A 126
THR A  46
 ARG  A 310 (-4.7A)
None
None
None
None
 1.21A 3qg2B-4h5gA:
undetectable		 3qg2B-4h5gA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4h5g AMINO ACID ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 SER A 236
ARG A 233
LEU A 232
ASP A 121
 ACT  A 305 ( 4.6A)
EDO  A 308 ( 4.1A)
None
None
 1.49A 4xdtA-4h5gA:
undetectable		 4xdtA-4h5gA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4h5g AMINO ACID ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 VAL A 135
TYR A 143
ALA A 216
 None
 0.52A 4ybnA-4h5gA:
undetectable		 4ybnA-4h5gA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 4h5g AMINO ACID ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 LEU A 239
LEU A  42
ILE A 247
ALA A  75
MET A  72
 None
 1.24A 5og9A-4h5gA:
undetectable		 5og9A-4h5gA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 4h5g AMINO ACID ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A  95
GLY A 109
ALA A 108
ILE A  86
VAL A  94
 GOL  A 306 ( 4.3A)
ARG  A 310 (-4.7A)
ARG  A 310 (-3.9A)
None
None
 0.90A 6dh0A-4h5gA:
undetectable		 6dh0A-4h5gA:
16.32