SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12
(Saccharomyces
cerevisiae) 		5 / 12 SER A 301
VAL A 293
LEU A 280
TYR A 342
PHE A   3
 None
 1.09A 1fduA-4h5iA:
undetectable		 1fduA-4h5iA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12
(Saccharomyces
cerevisiae) 		4 / 8 SER A 301
VAL A 293
LEU A 280
TYR A 342
 None
 1.10A 1fduB-4h5iA:
undetectable		 1fduB-4h5iA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  10
ILE A  76
LEU A  26
GLY A  29
ALA A  14
 None
 1.06A 1r9oA-4h5iA:
undetectable		 1r9oA-4h5iA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 329
ILE A  76
THR A 270
THR A  43
VAL A  10
 None
 1.13A 1rv7A-4h5iA:
undetectable
1rv7B-4h5iA:
undetectable		 1rv7A-4h5iA:
13.94
1rv7B-4h5iA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12
(Saccharomyces
cerevisiae) 		5 / 10 SER A  79
LEU A 164
SER A 162
ILE A 159
SER A 139
 None
 1.37A 3ijxB-4h5iA:
undetectable
3ijxD-4h5iA:
undetectable		 3ijxB-4h5iA:
23.48
3ijxD-4h5iA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 164
SER A 120
LEU A  84
PHE A 117
ASP A  70
 None
 1.23A 3ko0A-4h5iA:
undetectable
3ko0B-4h5iA:
undetectable
3ko0C-4h5iA:
undetectable
3ko0D-4h5iA:
undetectable		 3ko0A-4h5iA:
15.69
3ko0B-4h5iA:
15.69
3ko0C-4h5iA:
15.69
3ko0D-4h5iA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12
(Saccharomyces
cerevisiae) 		5 / 11 ASP A  70
PHE A 117
LEU A  84
LEU A 164
SER A 120
 None
 1.22A 3ko0A-4h5iA:
undetectable
3ko0B-4h5iA:
undetectable
3ko0I-4h5iA:
undetectable
3ko0J-4h5iA:
undetectable		 3ko0A-4h5iA:
15.69
3ko0B-4h5iA:
15.69
3ko0I-4h5iA:
15.69
3ko0J-4h5iA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  84
LEU A 164
SER A 120
ASP A  70
PHE A 117
 None
 1.20A 3ko0K-4h5iA:
undetectable
3ko0L-4h5iA:
undetectable
3ko0M-4h5iA:
undetectable
3ko0N-4h5iA:
undetectable		 3ko0K-4h5iA:
15.69
3ko0L-4h5iA:
15.69
3ko0M-4h5iA:
15.69
3ko0N-4h5iA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 117
ASP A  70
LEU A  84
LEU A 164
SER A 120
 None
 1.22A 3ko0M-4h5iA:
undetectable
3ko0N-4h5iA:
undetectable
3ko0O-4h5iA:
undetectable
3ko0P-4h5iA:
undetectable		 3ko0M-4h5iA:
15.69
3ko0N-4h5iA:
15.69
3ko0O-4h5iA:
15.69
3ko0P-4h5iA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  20
LEU A  45
VAL A  44
PHE A  19
 None
 1.24A 4uswA-4h5iA:
undetectable		 4uswA-4h5iA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 338
ASP A 320
ILE A 290
HIS A 334
 None
 1.08A 4xi3C-4h5iA:
undetectable		 4xi3C-4h5iA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12
(Saccharomyces
cerevisiae) 		4 / 4 GLY A  30
LEU A  45
PHE A  58
ILE A 333
 None
 0.96A 4xv2A-4h5iA:
undetectable		 4xv2A-4h5iA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  34
GLY A  32
GLU A  67
ASP A 122
ILE A  94
 K  A 401 (-4.7A)
K  A 401 (-4.7A)
None
None
None
 0.98A 5ehiA-4h5iA:
undetectable		 5ehiA-4h5iA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12
(Saccharomyces
cerevisiae) 		5 / 12 MET A 156
ILE A 170
SER A 182
VAL A 198
ILE A 199
 None
 1.38A 5mlmA-4h5iA:
undetectable		 5mlmA-4h5iA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4h5i GUANINE
NUCLEOTIDE-EXCHANGE
FACTOR SEC12
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 281
LEU A 338
ILE A 336
ILE A 290
SER A 271
 None
 1.16A 5uanB-4h5iA:
undetectable		 5uanB-4h5iA:
21.77