SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h5s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4h5s CELL ADHESION
MOLECULE 1
(Homo
sapiens) 		4 / 8 VAL B  96
ARG B  52
ALA B  16
GLU B  75
 None
 1.04A 1dmiA-4h5sB:
undetectable
1dmiB-4h5sB:
undetectable		 1dmiA-4h5sB:
13.98
1dmiB-4h5sB:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 4h5s CYTOTOXIC AND
REGULATORY T-CELL
MOLECULE
(Homo
sapiens) 		4 / 7 GLN A  74
ASP A  75
LEU A  49
SER A  37
 None
 1.02A 1ig3A-4h5sA:
undetectable
1ig3B-4h5sA:
undetectable		 1ig3A-4h5sA:
17.44
1ig3B-4h5sA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4h5s CELL ADHESION
MOLECULE 1
(Homo
sapiens) 		4 / 7 LEU B  32
GLN B  81
PHE B  79
PHE B  53
 None
 0.99A 2zxwC-4h5sB:
undetectable
2zxwJ-4h5sB:
undetectable		 2zxwC-4h5sB:
15.71
2zxwJ-4h5sB:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 4h5s CELL ADHESION
MOLECULE 1
CYTOTOXIC AND
REGULATORY T-CELL
MOLECULE
(Homo
sapiens) 		4 / 4 PHE A  39
LEU B  63
LEU B  33
VAL B  29
 None
 1.31A 5xxiA-4h5sA:
undetectable		 5xxiA-4h5sA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 4h5s CYTOTOXIC AND
REGULATORY T-CELL
MOLECULE
CELL ADHESION
MOLECULE 1
(Homo
sapiens;
Homo
sapiens) 		4 / 5 GLY A  38
LEU A  34
TYR B  83
GLN B  81
 None
 1.23A 6ji6A-4h5sA:
undetectable		 6ji6A-4h5sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4h5s CELL ADHESION
MOLECULE 1
(Homo
sapiens) 		4 / 5 LEU B  32
GLN B  81
PHE B  79
PHE B  53
 None
 0.99A 6nmpP-4h5sB:
undetectable
6nmpW-4h5sB:
undetectable		 6nmpP-4h5sB:
15.71
6nmpW-4h5sB:
15.46