SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		4 / 7 MET A 221
SER A  89
SER A 178
ALA A 167
 None
 1.17A 1fxvA-4h5uA:
undetectable
1fxvB-4h5uA:
undetectable		 1fxvA-4h5uA:
20.81
1fxvB-4h5uA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 112
VAL A  88
ILE A  30
SER A  74
LEU A  23
 None
 1.05A 1s19A-4h5uA:
undetectable		 1s19A-4h5uA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 107
GLU A 143
GLN A 148
 None
CAF  A 169 ( 4.8A)
None
 1.08A 2p16A-4h5uA:
undetectable		 2p16A-4h5uA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		5 / 9 LEU A   5
ILE A 266
ALA A 281
GLY A 162
LEU A 161
 None
 1.14A 2v0mB-4h5uA:
undetectable		 2v0mB-4h5uA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 115
GLU A 124
ALA A 194
LEU A  13
ILE A  90
 None
None
CAF  A 169 ( 4.4A)
None
None
 1.30A 2xkwB-4h5uA:
undetectable		 2xkwB-4h5uA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 111
GLY A  91
PRO A 192
ARG A 109
 None
None
CAF  A 169 ( 4.9A)
None
 0.93A 3bjwC-4h5uA:
undetectable		 3bjwC-4h5uA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 191
VAL A 219
ILE A 188
ILE A 157
PHE A  42
 None
 1.36A 3o5rA-4h5uA:
undetectable		 3o5rA-4h5uA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 121
GLN A  72
LEU A 113
LEU A  94
ILE A  34
 None
 1.14A 3ozwB-4h5uA:
undetectable		 3ozwB-4h5uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 127
VAL A 147
HIS A  93
 CAF  A 169 ( 2.7A)
None
None
 1.18A 3tj7A-4h5uA:
undetectable		 3tj7A-4h5uA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		4 / 7 VAL A  26
LEU A  29
ASN A 110
VAL A  41
 None
 0.75A 4e1gB-4h5uA:
undetectable		 4e1gB-4h5uA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		4 / 6 LYS A  27
ILE A  30
VAL A  88
LEU A  43
 None
 1.10A 4em2A-4h5uA:
undetectable		 4em2A-4h5uA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 164
LEU A 220
MET A 221
ILE A 172
GLY A 208
 None
None
None
CAF  A 169 ( 3.6A)
None
 1.18A 4j26A-4h5uA:
undetectable		 4j26A-4h5uA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  93
LEU A 130
ILE A 168
GLU A 143
SER A  57
 None
None
CAF  A 169 ( 3.9A)
CAF  A 169 ( 4.8A)
None
 1.37A 4r88B-4h5uA:
2.8		 4r88B-4h5uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  93
LEU A 130
ILE A 168
GLU A 143
SER A  57
 None
None
CAF  A 169 ( 3.9A)
CAF  A 169 ( 4.8A)
None
 1.40A 4r88C-4h5uA:
2.6		 4r88C-4h5uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  93
LEU A 130
ILE A 168
GLU A 143
SER A  57
 None
None
CAF  A 169 ( 3.9A)
CAF  A 169 ( 4.8A)
None
 1.38A 4r88D-4h5uA:
2.8		 4r88D-4h5uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  93
LEU A 130
ILE A 168
GLU A 143
SER A  57
 None
None
CAF  A 169 ( 3.9A)
CAF  A 169 ( 4.8A)
None
 1.36A 4r88E-4h5uA:
2.7		 4r88E-4h5uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  93
LEU A 130
ILE A 168
GLU A 143
SER A  57
 None
None
CAF  A 169 ( 3.9A)
CAF  A 169 ( 4.8A)
None
 1.39A 4r88F-4h5uA:
2.7		 4r88F-4h5uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  26
LEU A  13
ALA A  11
ILE A 157
ILE A  90
 None
 1.14A 5hbsA-4h5uA:
undetectable		 5hbsA-4h5uA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 283
ILE A 188
ILE A 168
TYR A 125
LEU A 112
 None
None
CAF  A 169 ( 3.9A)
None
None
 1.22A 5y2tB-4h5uA:
undetectable		 5y2tB-4h5uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4h5u PROBABLE HYDROLASE
NIT2
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  94
VAL A 111
VAL A  92
ILE A 115
ILE A 121
 None
 1.03A 5yf9X-4h5uA:
undetectable		 5yf9X-4h5uA:
15.58