SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		3 / 3 GLU A 160
HIS A 157
ASP A  81
 None
 0.76A 1i9gA-4h5yA:
undetectable		 1i9gA-4h5yA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		3 / 3 VAL A 447
LYS A 452
HIS A 469
 None
 0.82A 3elzA-4h5yA:
undetectable		 3elzA-4h5yA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		3 / 3 LEU A  93
ARG A 141
ASN A 124
 None
 0.73A 3qxvD-4h5yA:
undetectable		 3qxvD-4h5yA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		4 / 6 ALA A 212
ILE A 216
LEU A 152
ALA A 145
 None
 0.86A 3r9sC-4h5yA:
undetectable		 3r9sC-4h5yA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		4 / 4 LEU A 115
GLY A  92
LEU A  93
GLU A  91
 None
 1.10A 3tgvB-4h5yA:
undetectable		 3tgvB-4h5yA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		4 / 5 HIS A 317
LEU A 254
LEU A 394
ASP A 256
 None
 1.16A 4aqlA-4h5yA:
undetectable		 4aqlA-4h5yA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		5 / 12 ILE A 303
ALA A 271
LEU A 310
SER A 399
ILE A 395
 None
 1.28A 4gh8B-4h5yA:
undetectable		 4gh8B-4h5yA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		5 / 9 LEU A 247
GLY A 433
ASN A 435
VAL A 542
VAL A 538
 None
 1.06A 4qd3A-4h5yA:
undetectable		 4qd3A-4h5yA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		5 / 12 ILE A  86
ALA A 158
SER A  72
LEU A  73
LEU A 103
 None
 1.36A 4qztC-4h5yA:
undetectable		 4qztC-4h5yA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		5 / 12 ILE A  86
ALA A 158
THR A  63
SER A  72
LEU A 103
 None
 1.23A 4qztC-4h5yA:
undetectable		 4qztC-4h5yA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		3 / 3 GLU A 160
HIS A 157
ASP A  81
 None
 0.84A 5c0oG-4h5yA:
undetectable		 5c0oG-4h5yA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		3 / 3 SER A 579
LYS A 580
SER A 583
 None
 0.85A 6az3P-4h5yA:
undetectable		 6az3P-4h5yA:
9.01