SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h61'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4h61 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 6
(Schizosaccharomy
ces
pombe) 		4 / 4 THR A 106
VAL A  79
GLY A  75
THR A  74
 None
 0.90A 3cflA-4h61A:
undetectable		 3cflA-4h61A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4h61 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 6
(Schizosaccharomy
ces
pombe) 		4 / 4 GLN A  92
PRO A 104
VAL A 102
GLU A 101
 None
 1.50A 3huoA-4h61A:
undetectable		 3huoA-4h61A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 4h61 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 6
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A  78
ILE A  76
PHE A  37
THR A  12
ALA A 118
 None
 1.23A 5vcgA-4h61A:
undetectable		 5vcgA-4h61A:
16.29