SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
(Saccharomyces
cerevisiae) 		4 / 6 PRO Q 544
ASN Q 534
ASP Q 536
TYR Q 640
 None
 1.35A 1hpkA-4h62Q:
undetectable		 1hpkA-4h62Q:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
(Saccharomyces
cerevisiae) 		5 / 9 LEU Q 441
LEU Q 511
LEU Q 512
ILE Q 515
ILE Q 445
 None
 1.19A 2f78A-4h62Q:
undetectable		 2f78A-4h62Q:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
(Saccharomyces
cerevisiae) 		5 / 9 LEU Q 441
LEU Q 511
LEU Q 512
ILE Q 515
ILE Q 445
 None
 1.14A 2f78B-4h62Q:
undetectable		 2f78B-4h62Q:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
(Saccharomyces
cerevisiae) 		5 / 9 LEU Q 441
LEU Q 511
LEU Q 512
ILE Q 515
ILE Q 445
 None
 1.07A 2f7aA-4h62Q:
undetectable		 2f7aA-4h62Q:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
(Saccharomyces
cerevisiae) 		5 / 11 LEU Q 478
LEU Q 479
ILE Q 435
MET Q 411
LEU Q 508
 None
 1.10A 2ft9A-4h62Q:
3.7		 2ft9A-4h62Q:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 22
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 9 ILE Q 647
ILE Q 645
PHE Q 667
ILE Q 619
VAL V 116
 None
None
None
None
MES  Q 701 (-4.9A)
 1.28A 2ygpA-4h62Q:
undetectable		 2ygpA-4h62Q:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
(Saccharomyces
cerevisiae) 		5 / 11 LEU Q 546
ILE Q 445
ILE Q 453
ILE Q 467
ILE Q 542
 None
 1.10A 3ebzA-4h62Q:
undetectable		 3ebzA-4h62Q:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
(Saccharomyces
cerevisiae) 		4 / 5 ILE Q 647
PHE Q 673
ASP Q 672
GLU Q 669
 None
 0.91A 3kp6A-4h62Q:
undetectable
3kp6B-4h62Q:
undetectable		 3kp6A-4h62Q:
21.84
3kp6B-4h62Q:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
(Saccharomyces
cerevisiae) 		4 / 6 MET Q 411
GLU Q 408
GLU Q 477
GLU Q 475
 None
 1.37A 4r87H-4h62Q:
undetectable		 4r87H-4h62Q:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
(Saccharomyces
cerevisiae) 		4 / 7 MET Q 411
GLU Q 408
GLU Q 477
GLU Q 475
 None
 1.43A 4r87J-4h62Q:
undetectable
4r87L-4h62Q:
undetectable		 4r87J-4h62Q:
21.41
4r87L-4h62Q:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 11
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 22
(Saccharomyces
cerevisiae) 		4 / 5 GLU V 106
GLU V 113
THR V 114
LEU K 105
 None
 1.19A 5hm8G-4h62V:
undetectable		 5hm8G-4h62V:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
(Saccharomyces
cerevisiae) 		5 / 9 ILE Q 467
VAL Q 391
GLU Q 448
MET Q 442
ILE Q 545
 None
 1.47A 5mzpA-4h62Q:
undetectable		 5mzpA-4h62Q:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
(Saccharomyces
cerevisiae) 		4 / 6 VAL Q 566
LYS Q 563
ILE Q 619
LYS Q 559
 None
 1.50A 5q1sA-4h62Q:
undetectable		 5q1sA-4h62Q:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
(Saccharomyces
cerevisiae) 		4 / 6 ASN Q 642
ASN Q 639
ARG Q 550
GLU Q 636
 None
 1.24A 5uigA-4h62Q:
undetectable		 5uigA-4h62Q:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
(Saccharomyces
cerevisiae) 		4 / 7 ILE Q 569
GLU Q 671
HIS Q 675
VAL Q 678
 None
 1.02A 6j20A-4h62Q:
undetectable		 6j20A-4h62Q:
20.13