SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h63'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IG3_A_VIBA502_1 (THIAMIN PYROPHOSPHOKINASE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 (Schizosaccharomy ces pombe)	4 / 8	LEU K 111 SER Q 281 SER Q 269 THR Q 346	None	0.95A	1ig3A-4h63K: undetectable 1ig3B-4h63K: undetectable	1ig3A-4h63K: 18.15 1ig3B-4h63K: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TZ8_D_DESD128_1 (TRANSTHYRETIN)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 (Schizosaccharomy ces pombe)	4 / 4	LYS Q 212 LEU V  82 LEU Q 227 SER Q 228	None	1.33A	1tz8D-4h63Q: undetectable	1tz8D-4h63Q: 13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q83_B_ADNB2_1 (YTAA PROTEIN)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 (Schizosaccharomy ces pombe)	5 / 6	ILE K 104 CYH Q 401 PRO Q 422 LEU Q 314 ILE Q 424	None	1.46A	2q83B-4h63K: 3.2	2q83B-4h63K: 14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZJ0_B_2FAB500_2 (ADENOSYLHOMOCYSTEINA SE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 (Schizosaccharomy ces pombe)	4 / 5	LEU Q 347 GLN Q 263 THR Q 349 HIS Q 394	None	1.05A	2zj0B-4h63Q: undetectable	2zj0B-4h63Q: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZJ0_C_2FAC500_2 (ADENOSYLHOMOCYSTEINA SE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 (Schizosaccharomy ces pombe)	4 / 5	LEU Q 347 GLN Q 263 THR Q 349 HIS Q 394	None	1.16A	2zj0C-4h63Q: undetectable	2zj0C-4h63Q: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CE6_B_ADNB500_2 (ADENOSYLHOMOCYSTEINA SE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 (Schizosaccharomy ces pombe)	4 / 5	LEU Q 347 GLN Q 263 THR Q 349 HIS Q 394	None	1.19A	3ce6B-4h63Q: undetectable	3ce6B-4h63Q: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CE6_D_ADND500_2 (ADENOSYLHOMOCYSTEINA SE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 (Schizosaccharomy ces pombe)	4 / 5	LEU Q 347 GLN Q 263 THR Q 349 HIS Q 394	None	1.18A	3ce6D-4h63Q: undetectable	3ce6D-4h63Q: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E68_A_H4BA902_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 (Schizosaccharomy ces pombe)	3 / 3	ARG V  13 ILE K  24 TRP V  81	None	1.14A	3e68A-4h63V: undetectable	3e68A-4h63V: 14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_C_CHDC150_0 (ILEAL BILE ACID-BINDING PROTEIN)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	GLN K 107 ASN Q 390 THR Q 282 LEU Q 398 ILE Q 310	None	1.43A	3elzC-4h63K: undetectable	3elzC-4h63K: 22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KEE_B_30BB500_2 (GENOME POLYPROTEIN)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 (Schizosaccharomy ces pombe)	3 / 3	PHE Q 397 TYR K  95 LEU Q 473	None	0.75A	3keeB-4h63Q: undetectable	3keeB-4h63Q: 16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MDR_A_GJZA506_1 (CHOLESTEROL 24-HYDROXYLASE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 (Schizosaccharomy ces pombe)	4 / 6	LEU Q 469 ILE Q 392 ALA Q 391 THR V 106	None	1.08A	3mdrA-4h63Q: undetectable	3mdrA-4h63Q: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N58_C_ADNC500_2 (ADENOSYLHOMOCYSTEINA SE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 (Schizosaccharomy ces pombe)	4 / 5	LEU Q 347 GLN Q 263 THR Q 349 HIS Q 394	None	1.19A	3n58C-4h63Q: undetectable	3n58C-4h63Q: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NXU_B_RITB600_1 (CYTOCHROME P450 3A4)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 (Schizosaccharomy ces pombe)	5 / 12	SER Q 183 ILE V  56 ALA V  39 ILE K  45 ALA K  44	None	1.16A	3nxuB-4h63Q: undetectable	3nxuB-4h63Q: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_A_SAMA6735_1 (16S RRNA METHYLASE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 (Schizosaccharomy ces pombe)	3 / 3	ASP Q 124 GLU Q 118 SER Q 147	None	0.85A	3p2kA-4h63Q: undetectable	3p2kA-4h63Q: 20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R9C_A_ECLA452_1 (CYTOCHROME P450 164A2)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 (Schizosaccharomy ces pombe)	5 / 12	LEU Q 473 LEU V 107 THR Q 388 ASN Q 390 LEU Q 389	None	0.79A	3r9cA-4h63Q: undetectable	3r9cA-4h63Q: 20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUE_B_SUEB1201_2 (NS3 PROTEASE, NS4A PROTEIN)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 (Schizosaccharomy ces pombe)	3 / 3	PHE Q 397 TYR K  95 LEU Q 473	None	0.80A	3sueB-4h63Q: undetectable	3sueB-4h63Q: 16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UGR_A_IMNA2001_2 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 (Schizosaccharomy ces pombe)	4 / 7	GLU K  28 GLN K  22 TYR Q 205 PRO K  32	None	1.26A	3ugrA-4h63K: undetectable	3ugrA-4h63K: 14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAR_A_ERMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 (Schizosaccharomy ces pombe)	4 / 7	THR K  64 VAL Q 197 SER K  36 ASP V  72	None	1.40A	4iarA-4h63K: 3.7	4iarA-4h63K: 14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_B_FOLB703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	VAL V  64 PHE K  61 SER K  36 VAL V  67 THR V  60	None	1.44A	4kyaB-4h63V: undetectable	4kyaB-4h63V: 15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_D_FOLD703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	VAL V  64 PHE K  61 SER K  36 VAL V  67 THR V  60	None	1.45A	4kyaD-4h63V: undetectable	4kyaD-4h63V: 15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_F_FOLF703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	VAL V  64 PHE K  61 SER K  36 VAL V  67 THR V  60	None	1.44A	4kyaF-4h63V: undetectable	4kyaF-4h63V: 15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KYA_H_FOLH703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	VAL V  64 PHE K  61 SER K  36 VAL V  67 THR V  60	None	1.46A	4kyaH-4h63V: undetectable	4kyaH-4h63V: 15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MGH_A_ACTA1320_0 (PHOSPHORIBOSYLFORMYL GLYCINAMIDINE SYNTHASE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 (Schizosaccharomy ces pombe)	4 / 5	VAL Q 326 LEU Q 425 ILE Q 333 LEU Q 334	None	0.86A	4mghA-4h63Q: undetectable	4mghA-4h63Q: 16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R38_A_RBFA201_2 (BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 (Schizosaccharomy ces pombe)	4 / 8	ILE K  24 VAL V  67 LEU V  70 ILE V  28	None	0.68A	4r38A-4h63K: undetectable	4r38A-4h63K: 19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AXA_C_ADNC502_2 (ADENOSYLHOMOCYSTEINA SE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 (Schizosaccharomy ces pombe)	4 / 5	GLU Q 348 THR Q 349 HIS Q 400 LEU Q 314	None	1.24A	5axaC-4h63Q: undetectable	5axaC-4h63Q: 20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BYK_A_OAQA302_0 (SULFOTRANSFERASE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 (Schizosaccharomy ces pombe; Schizosaccharomy ces pombe)	5 / 12	ILE V  77 LEU K  77 VAL K  84 THR V  14 THR V  83	None	1.29A	5bykA-4h63V: undetectable	5bykA-4h63V: 20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HW8_F_FK5F201_1 (FK506-BINDING PROTEIN 1)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 (Schizosaccharomy ces pombe)	5 / 12	ARG V  31 VAL V  67 ILE V  28 ILE V  35 PHE K  61	None	1.03A	5hw8B-4h63V: undetectable 5hw8F-4h63V: undetectable 5hw8G-4h63V: undetectable	5hw8B-4h63V: 21.13 5hw8F-4h63V: 21.13 5hw8G-4h63V: 21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_G_EY4G501_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 (Schizosaccharomy ces pombe)	4 / 7	ILE V  77 VAL V  73 ILE V  21 THR V  25	None	1.00A	6cduF-4h63V: 3.7 6cduG-4h63V: 3.6	6cduF-4h63V: 19.70 6cduG-4h63V: 19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HCX_A_ZMRA519_1 (NEURAMINIDASE)	4h63	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 (Schizosaccharomy ces pombe)	3 / 3	TRP Q 311 ILE Q 345 GLU Q 317	None	0.73A	6hcxA-4h63Q: undetectable	6hcxA-4h63Q: 10.28