SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h65'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 209
GLU A 215
VAL A 217
ILE A  39
ILE A  21
 None
 0.95A 1fapA-4h65A:
undetectable		 1fapA-4h65A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 209
GLU A 215
VAL A 217
ILE A  39
ILE A  21
 None
 1.04A 1fklA-4h65A:
undetectable		 1fklA-4h65A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  83
ASN A  11
LEU A  10
PHE A   8
 None
 1.42A 1ru9H-4h65A:
undetectable
1ru9L-4h65A:
undetectable		 1ru9H-4h65A:
22.16
1ru9L-4h65A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  83
ASN A  11
LEU A  10
PHE A   8
 None
 1.44A 1rukH-4h65A:
undetectable
1rukL-4h65A:
undetectable		 1rukH-4h65A:
22.16
1rukL-4h65A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 324
HIS A 323
ARG A 335
 None
 1.03A 1zlqA-4h65A:
0.6		 1zlqA-4h65A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 229
LEU A 232
ILE A  19
PRO A  20
 None
 1.22A 3s3vA-4h65A:
undetectable		 3s3vA-4h65A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 224
LEU A  84
LEU A 269
ALA A  81
LEU A  61
 None
 0.99A 3vrmA-4h65A:
undetectable		 3vrmA-4h65A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  73
PHE A  75
PRO A  76
 None
 0.89A 3zoaB-4h65A:
undetectable		 3zoaB-4h65A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 325
GLN A 165
ARG A 186
ILE A 160
CYH A 162
 None
 1.33A 4k38A-4h65A:
undetectable
4k38D-4h65A:
undetectable		 4k38A-4h65A:
21.50
4k38D-4h65A:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 325
GLN A 165
ARG A 186
ILE A 160
LEU A  84
 None
 1.27A 4k38A-4h65A:
undetectable
4k38D-4h65A:
undetectable		 4k38A-4h65A:
21.50
4k38D-4h65A:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 325
GLN A 165
ARG A 186
ILE A 160
LEU A  84
 None
 1.31A 4k38B-4h65A:
undetectable		 4k38B-4h65A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 325
GLN A 165
ARG A 186
ILE A 160
LEU A  84
 None
 1.34A 4k39A-4h65A:
undetectable		 4k39A-4h65A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  30
ILE A  21
PRO A  20
LEU A 269
PHE A   8
 None
 1.27A 5im2A-4h65A:
5.8		 5im2A-4h65A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 331
CYH A 327
LYS A 326
HIS A 323
 None
 1.44A 5jliA-4h65A:
undetectable		 5jliA-4h65A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JRA_A_ASCA202_0
(CYTOCHROME C')		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		4 / 4 GLY A 331
CYH A 327
LYS A 326
HIS A 323
 None
 1.40A 5jraA-4h65A:
undetectable		 5jraA-4h65A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 331
CYH A 327
LYS A 326
HIS A 323
 None
 1.46A 5jt4A-4h65A:
undetectable		 5jt4A-4h65A:
16.94