SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4h6b ALLENE OXIDE CYCLASE
(Physcomitrella
patens) 		4 / 7 LEU A 133
TYR A  87
GLY A 105
TYR A 144
 None
10Y  A 202 ( 3.8A)
None
None
 0.94A 1lweA-4h6bA:
undetectable		 1lweA-4h6bA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 4h6b ALLENE OXIDE CYCLASE
(Physcomitrella
patens) 		4 / 6 LYS A 176
ALA A 175
LEU A  62
VAL A 183
 None
 1.20A 1sn5A-4h6bA:
undetectable		 1sn5A-4h6bA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 4h6b ALLENE OXIDE CYCLASE
(Physcomitrella
patens) 		4 / 7 GLY A  34
GLY A  33
LEU A  75
PHE A  29
 None
 0.69A 3o9mA-4h6bA:
undetectable		 3o9mA-4h6bA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4h6b ALLENE OXIDE CYCLASE
(Physcomitrella
patens) 		3 / 3 LEU A 154
PRO A 155
LEU A 158
 None
 0.48A 3w1wB-4h6bA:
undetectable		 3w1wB-4h6bA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4h6b ALLENE OXIDE CYCLASE
(Physcomitrella
patens) 		5 / 12 HIS A 100
GLY A  96
GLY A  67
ASP A  97
GLY A 120
 PO4  A 203 (-3.7A)
None
None
None
None
 1.15A 4blvA-4h6bA:
undetectable		 4blvA-4h6bA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4h6b ALLENE OXIDE CYCLASE
(Physcomitrella
patens) 		4 / 6 GLU A  18
THR A 145
TYR A 144
PHE A  53
 10X  A 201 ( 3.0A)
None
None
10Y  A 202 ( 3.7A)
 1.42A 5lrbA-4h6bA:
undetectable		 5lrbA-4h6bA:
11.73