SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 4h6j HYPOXIA INDUCIBLE
FACTOR 1-ALPHA
(Homo
sapiens) 		5 / 12 ILE A 335
TYR A 276
TYR A 279
HIS A 291
CYH A 337
 None
 1.42A 1s9aB-4h6jA:
undetectable		 1s9aB-4h6jA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 4h6j ARYL HYDROCARBON
NUCLEAR TRANSLOCATOR
(Homo
sapiens) 		5 / 12 ILE B 457
THR B 445
VAL B 415
ILE B 369
GLU B 370
 None
 1.27A 2yzqA-4h6jB:
undetectable		 2yzqA-4h6jB:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 4h6j ARYL HYDROCARBON
NUCLEAR TRANSLOCATOR
(Homo
sapiens) 		5 / 12 HIS B 367
PHE B 429
LEU B 391
VAL B 376
VAL B 384
 None
 1.19A 3czvA-4h6jB:
undetectable
3czvB-4h6jB:
undetectable		 3czvA-4h6jB:
14.72
3czvB-4h6jB:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 4h6j ARYL HYDROCARBON
NUCLEAR TRANSLOCATOR
(Homo
sapiens) 		5 / 10 ASN B 461
GLY B 371
PHE B 412
PHE B 429
PHE B 427
 None
 1.50A 3r6wA-4h6jB:
undetectable
3r6wB-4h6jB:
undetectable		 3r6wA-4h6jB:
21.54
3r6wB-4h6jB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 4h6j ARYL HYDROCARBON
NUCLEAR TRANSLOCATOR
(Homo
sapiens) 		5 / 10 VAL B 416
ILE B 369
GLY B 371
ILE B 396
VAL B 415
 None
 0.95A 3t3cB-4h6jB:
undetectable		 3t3cB-4h6jB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4h6j ARYL HYDROCARBON
NUCLEAR TRANSLOCATOR
(Homo
sapiens) 		3 / 3 TYR B 386
ARG B 430
SER B 431
 None
 1.17A 4dr2I-4h6jB:
undetectable
4dr2J-4h6jB:
undetectable		 4dr2I-4h6jB:
16.92
4dr2J-4h6jB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4h6j ARYL HYDROCARBON
NUCLEAR TRANSLOCATOR
HYPOXIA INDUCIBLE
FACTOR 1-ALPHA
(Homo
sapiens) 		4 / 5 ILE A 324
PHE A 242
SER B 443
ASP B 377
 None
 0.97A 4rzvB-4h6jA:
undetectable		 4rzvB-4h6jA:
18.18