SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h6q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		4 / 5 TYR A 288
LEU A 257
VAL A 164
ASP A 135
 TFB  A2002 (-4.7A)
FAD  A2001 (-3.8A)
FAD  A2001 (-4.1A)
TFB  A2002 ( 3.7A)
 1.38A 1dz6A-4h6qA:
undetectable		 1dz6A-4h6qA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 10 GLY A 114
GLY A 105
THR A 116
ASN A 117
VAL A 102
 None
 1.34A 1pwyE-4h6qA:
undetectable		 1pwyE-4h6qA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 12 GLY A  90
ALA A  89
ILE A  83
ALA A  43
ILE A  44
 None
 0.73A 1rl8A-4h6qA:
undetectable		 1rl8A-4h6qA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		4 / 6 ASP A  60
VAL A  95
ILE A 132
TYR A 193
 None
None
None
FAD  A2001 (-4.1A)
 0.75A 1s9qA-4h6qA:
undetectable		 1s9qA-4h6qA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TJ2_A_ACTA2002_0
(BIFUNCTIONAL PUTA
PROTEIN)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 5 LYS A  98
ALA A 192
TYR A 288
ARG A 291
ARG A 292
 TFB  A2002 (-2.8A)
FAD  A2001 (-3.1A)
TFB  A2002 (-4.7A)
TFB  A2002 (-3.8A)
TFB  A2002 ( 2.6A)
 0.42A 1tj2A-4h6qA:
31.5		 1tj2A-4h6qA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 12 GLY A  90
ALA A  89
ILE A  83
ALA A  43
ILE A  44
 None
 0.79A 2b60A-4h6qA:
undetectable		 2b60A-4h6qA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 11 GLY A  90
ALA A  89
ILE A  83
ALA A  43
ILE A  44
 None
 0.79A 2b60B-4h6qA:
undetectable		 2b60B-4h6qA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 12 GLY A  90
ALA A  89
ILE A  83
ALA A  43
ILE A  44
 None
 0.75A 2nmyB-4h6qA:
undetectable		 2nmyB-4h6qA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 12 GLY A  90
ALA A  89
ILE A  83
ALA A  43
ILE A  44
 None
 0.76A 2rkfA-4h6qA:
undetectable		 2rkfA-4h6qA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 12 GLY A  90
ALA A  89
ILE A  83
ALA A  43
ILE A  44
 None
 0.77A 3ekwB-4h6qA:
undetectable		 3ekwB-4h6qA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 12 ASP A 175
VAL A 142
LEU A 165
THR A 163
ASP A 143
 None
 1.35A 3mbhE-4h6qA:
undetectable		 3mbhE-4h6qA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 12 PHE A 149
ASP A 181
LEU A 179
ARG A 176
LEU A 146
 None
 0.81A 3nrrA-4h6qA:
undetectable		 3nrrA-4h6qA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		3 / 3 LYS A  98
ARG A 292
LEU A  62
 TFB  A2002 (-2.8A)
TFB  A2002 ( 2.6A)
None
 0.94A 3v4tE-4h6qA:
1.8		 3v4tE-4h6qA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 12 TYR A 278
ASP A  60
GLN A 166
VAL A 164
ILE A 132
 TFB  A2002 ( 3.5A)
None
FAD  A2001 (-3.7A)
FAD  A2001 (-4.1A)
None
 1.26A 4drhA-4h6qA:
undetectable		 4drhA-4h6qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 12 TYR A 278
ASP A  60
GLN A 166
VAL A 164
ILE A 132
 TFB  A2002 ( 3.5A)
None
FAD  A2001 (-3.7A)
FAD  A2001 (-4.1A)
None
 1.24A 4drhD-4h6qA:
undetectable		 4drhD-4h6qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		4 / 5 VAL A 238
ILE A 234
VAL A 227
THR A 229
 None
None
None
FAD  A2001 (-3.5A)
 0.63A 4xdtA-4h6qA:
undetectable		 4xdtA-4h6qA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		4 / 7 SER A  96
ASP A 135
TYR A 288
ASN A  58
 None
TFB  A2002 ( 3.7A)
TFB  A2002 (-4.7A)
None
 1.16A 5l1fC-4h6qA:
undetectable		 5l1fC-4h6qA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4h6q PROLINE
DEHYDROGENASE
(Deinococcus
radiodurans) 		5 / 12 LEU A  82
LEU A 279
ASN A  58
ILE A  44
ALA A  86
 None
 1.15A 5nm5B-4h6qA:
2.9		 5nm5B-4h6qA:
21.08