SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h6w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 LEU A 104
ALA A 152
THR A 220
THR A 224
TYR A 193
 None
 0.99A 1cbsA-4h6wA:
undetectable		 1cbsA-4h6wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 ALA A 153
THR A 127
LEU A 136
TYR A 193
THR A 224
 None
 1.16A 1dhfA-4h6wA:
undetectable		 1dhfA-4h6wA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 ALA A 153
THR A 127
LEU A 136
TYR A 193
THR A 224
 None
 1.12A 1dhfB-4h6wA:
undetectable		 1dhfB-4h6wA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 ALA A 153
THR A 127
LEU A 136
TYR A 193
THR A 224
 None
 1.11A 1dyiB-4h6wA:
undetectable		 1dyiB-4h6wA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		4 / 8 PHE A  70
SER A 228
ALA A 232
ILE A 118
 None
 1.12A 1gm7A-4h6wA:
undetectable
1gm7B-4h6wA:
undetectable		 1gm7A-4h6wA:
21.90
1gm7B-4h6wA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		4 / 8 PHE A  70
SER A 228
ALA A 232
ILE A 118
 None
 1.16A 1pnlA-4h6wA:
undetectable
1pnlB-4h6wA:
undetectable		 1pnlA-4h6wA:
21.90
1pnlB-4h6wA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		4 / 6 PRO A 201
LEU A 280
ILE A 279
SER A 257
 None
 1.12A 1sbrA-4h6wA:
undetectable
1sbrB-4h6wA:
undetectable		 1sbrA-4h6wA:
23.45
1sbrB-4h6wA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 ALA A 200
ILE A 198
ILE A 226
VAL A 230
ILE A 118
 None
 1.14A 1xozA-4h6wA:
undetectable		 1xozA-4h6wA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 LEU A 104
ALA A 152
THR A 220
THR A 224
TYR A 193
 None
 0.96A 2fr3A-4h6wA:
undetectable		 2fr3A-4h6wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		4 / 8 ALA A 253
GLY A 197
SER A 257
ALA A 258
 None
 0.75A 2vh3B-4h6wA:
undetectable		 2vh3B-4h6wA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 10 ALA A 153
THR A 127
LEU A 136
TYR A 193
THR A 224
 None
 1.13A 2w3aB-4h6wA:
undetectable		 2w3aB-4h6wA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		3 / 3 ASN A 120
ASP A  26
ARG A 216
 None
 0.73A 3k13C-4h6wA:
undetectable		 3k13C-4h6wA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 9 LEU A 150
LEU A 142
ALA A 111
GLU A 109
ALA A 139
 None
 1.15A 3mdvA-4h6wA:
undetectable		 3mdvA-4h6wA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 VAL A  65
HIS A  61
ASP A  26
GLY A 219
ALA A 123
 None
 0.73A 3sufB-4h6wA:
undetectable		 3sufB-4h6wA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 HIS A  61
ASP A  26
GLY A 219
SER A 221
ALA A 123
 None
 0.95A 3sufD-4h6wA:
undetectable		 3sufD-4h6wA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 VAL A  65
HIS A  61
ASP A  26
GLY A 219
ALA A 123
 None
 0.76A 3sufD-4h6wA:
undetectable		 3sufD-4h6wA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 ALA A 153
THR A 127
LEU A 136
TYR A 193
THR A 224
 None
 1.21A 4cd2A-4h6wA:
undetectable		 4cd2A-4h6wA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 LEU A  10
LEU A   7
ILE A 279
GLY A 229
LEU A 234
 None
 1.02A 4lmnA-4h6wA:
undetectable		 4lmnA-4h6wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 ALA A 153
THR A 127
LEU A 136
TYR A 193
THR A 224
 None
 1.10A 4pthA-4h6wA:
undetectable		 4pthA-4h6wA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 ALA A 153
THR A 127
LEU A 136
TYR A 193
THR A 224
 None
 1.12A 4qleA-4h6wA:
undetectable		 4qleA-4h6wA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 ALA A 153
THR A 127
LEU A 136
TYR A 193
THR A 224
 None
 1.13A 4x5fA-4h6wA:
undetectable		 4x5fA-4h6wA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 ALA A 153
THR A 127
LEU A 136
TYR A 193
THR A 224
 None
 1.13A 4x5fB-4h6wA:
undetectable		 4x5fB-4h6wA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		4 / 6 GLN A 196
LEU A 273
MET A 274
LEU A 255
 None
 1.23A 4xp3A-4h6wA:
undetectable		 4xp3A-4h6wA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		5 / 12 ALA A 132
LEU A 168
ILE A  68
GLY A  62
LEU A  97
 None
 1.16A 5eshA-4h6wA:
undetectable		 5eshA-4h6wA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		3 / 3 ASN A 147
PRO A 247
GLN A 238
 None
 0.90A 6jnhA-4h6wA:
undetectable		 6jnhA-4h6wA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4h6w N-TERMINAL
CYANOBACTIN PROTEASE
(Planktothrix
agardhii) 		3 / 3 ASN A 147
PRO A 247
GLN A 238
 None
 0.89A 6jogA-4h6wA:
undetectable		 6jogA-4h6wA:
19.87