SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h6x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 ALA A 786
HIS A 618
ALA A 785
THR A 625
ILE A 766
 None
 1.12A 1gtnB-4h6xA:
undetectable
1gtnC-4h6xA:
undetectable		 1gtnB-4h6xA:
13.06
1gtnC-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 ALA A 786
HIS A 618
ALA A 785
THR A 625
ILE A 766
 None
 1.10A 1gtnH-4h6xA:
undetectable
1gtnI-4h6xA:
undetectable		 1gtnH-4h6xA:
13.06
1gtnI-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 11 HIS A 618
ALA A 785
THR A 625
ILE A 766
ALA A 786
 None
 1.14A 1gtnM-4h6xA:
undetectable
1gtnN-4h6xA:
undetectable		 1gtnM-4h6xA:
13.06
1gtnN-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		4 / 6 ASN A 645
GLY A 628
PRO A 787
ILE A 546
 None
 0.91A 1n49D-4h6xA:
undetectable		 1n49D-4h6xA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		3 / 3 THR A 743
GLU A 764
HIS A 746
 None
 0.86A 1xwfA-4h6xA:
undetectable		 1xwfA-4h6xA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		3 / 3 THR A 743
GLU A 764
HIS A 746
 None
 0.85A 1xwfB-4h6xA:
undetectable		 1xwfB-4h6xA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		3 / 3 THR A 743
GLU A 764
HIS A 746
 None
 0.87A 1xwfC-4h6xA:
undetectable		 1xwfC-4h6xA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		3 / 3 THR A 743
GLU A 764
HIS A 746
 None
 0.86A 1xwfD-4h6xA:
undetectable		 1xwfD-4h6xA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 11 LEU A 733
ALA A 786
ILE A 546
ILE A 637
VAL A 712
 None
 0.93A 2nnpB-4h6xA:
undetectable		 2nnpB-4h6xA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_B_3TCB302_1
(DEOXYCYTIDINE KINASE)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 11 ILE A 679
LEU A 816
GLN A 800
ALA A 811
ASP A 808
 None
 1.23A 2noaB-4h6xA:
undetectable		 2noaB-4h6xA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		3 / 3 VAL A 740
ASP A 741
GLU A 764
 None
 0.70A 2qeuA-4h6xA:
undetectable		 2qeuA-4h6xA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		3 / 3 VAL A 740
ASP A 741
GLU A 764
 None
 0.69A 2qeuC-4h6xA:
undetectable		 2qeuC-4h6xA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 ALA A 844
LEU A 796
VAL A 839
ILE A 637
THR A 819
 None
 1.12A 2w9gA-4h6xA:
undetectable		 2w9gA-4h6xA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 ALA A 844
LEU A 796
VAL A 839
ILE A 637
THR A 819
 None
 1.11A 2w9hA-4h6xA:
undetectable		 2w9hA-4h6xA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 12 ILE A 637
GLY A 791
GLY A 538
LEU A 537
HIS A 533
 None
 1.19A 2y7kD-4h6xA:
undetectable		 2y7kD-4h6xA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 9 ALA A 844
LEU A 796
VAL A 839
ILE A 637
THR A 819
 None
 1.15A 3freX-4h6xA:
undetectable		 3freX-4h6xA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 12 ALA A 785
ILE A 792
SER A 713
VAL A 712
ILE A 679
 None
 0.99A 4ax8A-4h6xA:
undetectable		 4ax8A-4h6xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 ALA A 786
HIS A 618
ALA A 785
THR A 625
ILE A 766
 None
 1.10A 5eeuF-4h6xA:
undetectable
5eeuG-4h6xA:
undetectable		 5eeuF-4h6xA:
13.06
5eeuG-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 HIS A 618
ALA A 785
THR A 625
ILE A 766
ALA A 786
 None
 1.13A 5eeuQ-4h6xA:
undetectable
5eeuR-4h6xA:
undetectable		 5eeuQ-4h6xA:
13.06
5eeuR-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 ALA A 786
HIS A 618
ALA A 785
THR A 625
ILE A 766
 None
 1.10A 5eevF-4h6xA:
undetectable
5eevG-4h6xA:
undetectable		 5eevF-4h6xA:
13.06
5eevG-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 HIS A 618
ALA A 785
THR A 625
ILE A 766
ALA A 786
 None
 1.13A 5eevQ-4h6xA:
undetectable
5eevR-4h6xA:
undetectable		 5eevQ-4h6xA:
13.06
5eevR-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 ALA A 786
HIS A 618
ALA A 785
THR A 625
ILE A 766
 None
 1.10A 5eewF-4h6xA:
undetectable
5eewG-4h6xA:
undetectable		 5eewF-4h6xA:
13.06
5eewG-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 HIS A 618
ALA A 785
THR A 625
ILE A 766
ALA A 786
 None
 1.13A 5eewQ-4h6xA:
undetectable
5eewR-4h6xA:
undetectable		 5eewQ-4h6xA:
13.06
5eewR-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 ALA A 786
HIS A 618
ALA A 785
THR A 625
ILE A 766
 None
 1.10A 5eexF-4h6xA:
undetectable
5eexG-4h6xA:
undetectable		 5eexF-4h6xA:
13.06
5eexG-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 ALA A 786
HIS A 618
ALA A 785
THR A 625
ILE A 766
 None
 1.10A 5eeyF-4h6xA:
undetectable
5eeyG-4h6xA:
undetectable		 5eeyF-4h6xA:
13.06
5eeyG-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 ALA A 786
HIS A 618
ALA A 785
THR A 625
ILE A 766
 None
 1.10A 5eezF-4h6xA:
undetectable
5eezG-4h6xA:
undetectable		 5eezF-4h6xA:
13.06
5eezG-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 ALA A 786
HIS A 618
ALA A 785
THR A 625
ILE A 766
 None
 1.10A 5ef0F-4h6xA:
undetectable
5ef0G-4h6xA:
undetectable		 5ef0F-4h6xA:
13.06
5ef0G-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 ALA A 786
HIS A 618
ALA A 785
THR A 625
ILE A 766
 None
 1.10A 5ef1F-4h6xA:
undetectable
5ef1G-4h6xA:
undetectable		 5ef1F-4h6xA:
13.06
5ef1G-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 ALA A 786
HIS A 618
ALA A 785
THR A 625
ILE A 766
 None
 1.11A 5ef2F-4h6xA:
undetectable
5ef2G-4h6xA:
undetectable		 5ef2F-4h6xA:
13.06
5ef2G-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 10 ALA A 786
HIS A 618
ALA A 785
THR A 625
ILE A 766
 None
 1.10A 5ef3F-4h6xA:
undetectable
5ef3G-4h6xA:
undetectable		 5ef3F-4h6xA:
13.06
5ef3G-4h6xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		4 / 6 PHE A 567
CYH A 620
THR A 623
PHE A 558
 None
 1.43A 5mwyA-4h6xA:
undetectable		 5mwyA-4h6xA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		5 / 12 LEU A 779
VAL A 777
GLY A 768
SER A 624
VAL A 614
 None
 1.43A 6a94A-4h6xA:
undetectable		 6a94A-4h6xA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE
(Prochloron
didemni) 		4 / 8 GLY A 791
LEU A 537
GLY A 538
LEU A 795
 None
 0.74A 6mdqA-4h6xA:
undetectable		 6mdqA-4h6xA:
11.64