SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 PHE A 998
VAL A 954
VAL A1023
ILE A1024
 None
 0.86A 1p7rA-4h6yA:
undetectable		 1p7rA-4h6yA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 PHE A 998
VAL A 954
GLY A 937
VAL A1023
ILE A1024
 None
 1.19A 1phgA-4h6yA:
undetectable		 1phgA-4h6yA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 PHE A 998
VAL A 954
GLY A 937
VAL A1023
ILE A1024
 None
 1.18A 2a1oB-4h6yA:
undetectable		 2a1oB-4h6yA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ILE A 544
ARG A 698
GLN A 694
LEU A 935
 None
 1.01A 2xrhA-4h6yA:
undetectable		 2xrhA-4h6yA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 GLU A 560
ASP A 558
TYR A 675
 None
 0.82A 2yvlB-4h6yA:
undetectable		 2yvlB-4h6yA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ARG A 688
ARG A 698
GLU A1018
GLU A1022
 None
 1.16A 3k9fA-4h6yA:
undetectable
3k9fB-4h6yA:
undetectable
3k9fD-4h6yA:
undetectable		 3k9fA-4h6yA:
20.63
3k9fB-4h6yA:
20.63
3k9fD-4h6yA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 999
VAL A1006
HIS A1001
 None
 1.12A 3tj7A-4h6yA:
undetectable		 3tj7A-4h6yA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 559
LEU A 556
GLU A 552
TYR A 555
 None
 1.13A 4f3tA-4h6yA:
undetectable		 4f3tA-4h6yA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PRO A 685
LEU A 556
GLU A 552
TYR A 555
 None
 1.31A 4z4cA-4h6yA:
undetectable		 4z4cA-4h6yA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 559
PRO A 685
GLU A 552
TYR A 555
 None
 1.25A 4z4gA-4h6yA:
undetectable		 4z4gA-4h6yA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 606
LEU A 599
THR A 551
GLN A 694
 None
 1.07A 5hbsA-4h6yA:
undetectable		 5hbsA-4h6yA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 606
LEU A 599
THR A 551
GLN A 694
 None
 1.04A 5ljbA-4h6yA:
undetectable		 5ljbA-4h6yA:
15.51