SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 4h7a CRISPR-ASSOCIATED
PROTEIN CSE2
(Thermus
thermophilus) 		3 / 3 ALA A  61
HIS A  62
VAL A  65
 None
 0.31A 1lqtB-4h7aA:
undetectable		 1lqtB-4h7aA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 4h7a CRISPR-ASSOCIATED
PROTEIN CSE2
(Thermus
thermophilus) 		3 / 3 ALA A  61
HIS A  62
VAL A  65
 None
 0.33A 1lquB-4h7aA:
undetectable		 1lquB-4h7aA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4h7a CRISPR-ASSOCIATED
PROTEIN CSE2
(Thermus
thermophilus) 		4 / 7 GLU A  88
ILE A 126
ALA A 106
ILE A 111
 None
 0.84A 2xkwA-4h7aA:
undetectable		 2xkwA-4h7aA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4h7a CRISPR-ASSOCIATED
PROTEIN CSE2
(Thermus
thermophilus) 		5 / 12 LEU A  49
HIS A  62
LEU A 136
LEU A 132
GLY A   4
 None
 1.46A 3g1uC-4h7aA:
undetectable		 3g1uC-4h7aA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4h7a CRISPR-ASSOCIATED
PROTEIN CSE2
(Thermus
thermophilus) 		5 / 12 LEU A 131
ASP A  75
GLY A 125
ALA A  83
VAL A 119
 None
 1.26A 5kbwB-4h7aA:
undetectable		 5kbwB-4h7aA:
23.28