SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		4 / 8 GLY A 338
GLY A 340
TYR A 294
VAL A  72
 None
 0.85A 1dbbH-4h7nA:
undetectable
1dbbL-4h7nA:
undetectable		 1dbbH-4h7nA:
18.70
1dbbL-4h7nA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		5 / 11 GLY A 207
THR A 206
LEU A 264
ARG A 441
GLY A 231
 None
 1.25A 1i7qA-4h7nA:
undetectable		 1i7qA-4h7nA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		4 / 4 LEU A 179
PRO A 100
ILE A 145
LEU A 148
 None
 1.07A 1ya4B-4h7nA:
undetectable		 1ya4B-4h7nA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		5 / 12 THR A 362
GLY A 364
GLN A 261
THR A 259
ILE A 313
 None
 1.11A 2azxA-4h7nA:
undetectable		 2azxA-4h7nA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		5 / 12 THR A 362
GLY A 364
GLN A 261
THR A 259
ILE A 313
 None
 1.11A 2azxB-4h7nA:
undetectable		 2azxB-4h7nA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		4 / 5 ALA A 419
TRP A 253
LEU A 252
ALA A 418
 None
 0.56A 2jstA-4h7nA:
undetectable
2jstB-4h7nA:
undetectable		 2jstA-4h7nA:
10.53
2jstB-4h7nA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		5 / 12 LEU A 148
LEU A 179
VAL A 176
ILE A  60
PHE A  88
 None
 1.28A 2weyA-4h7nA:
undetectable		 2weyA-4h7nA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		3 / 3 SER A 440
GLY A 443
GLY A 427
 None
 0.57A 3bogA-4h7nA:
undetectable
3bogC-4h7nA:
undetectable		 3bogA-4h7nA:
undetectable
3bogC-4h7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		5 / 12 ASN A  73
VAL A   7
VAL A 297
LEU A  78
THR A  81
 None
 1.36A 3elzA-4h7nA:
undetectable		 3elzA-4h7nA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		5 / 12 ILE A 145
LEU A 137
ILE A  60
ARG A  64
LEU A  89
 None
 1.20A 3ia4B-4h7nA:
undetectable		 3ia4B-4h7nA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		4 / 4 GLY A 212
VAL A 215
GLY A 190
THR A 192
 None
 0.92A 3ib2A-4h7nA:
undetectable		 3ib2A-4h7nA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		4 / 6 LEU A 389
GLU A 229
SER A 390
THR A 421
 None
 1.45A 3ropA-4h7nA:
undetectable		 3ropA-4h7nA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		4 / 8 PHE A 394
ALA A 236
ALA A 419
THR A 421
 None
 0.96A 3t3sF-4h7nA:
undetectable		 3t3sF-4h7nA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		5 / 12 ILE A 161
VAL A   7
TYR A  17
ASP A  16
ILE A 306
 None
 1.27A 3vrjA-4h7nA:
undetectable
3vrjC-4h7nA:
undetectable		 3vrjA-4h7nA:
19.67
3vrjC-4h7nA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		3 / 3 GLY A 260
GLU A 361
THR A 362
 None
 0.55A 4kouA-4h7nA:
undetectable		 4kouA-4h7nA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		3 / 3 GLY A 303
PRO A 304
GLN A 261
 None
 0.43A 4oltB-4h7nA:
undetectable		 4oltB-4h7nA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		5 / 12 GLY A 190
ASN A 195
ILE A  19
VAL A 156
VAL A   7
 None
 1.03A 4q5mA-4h7nA:
undetectable		 4q5mA-4h7nA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		3 / 3 GLY A 303
PRO A 304
GLN A 261
 None
 0.31A 4qwpB-4h7nA:
undetectable		 4qwpB-4h7nA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		4 / 6 LEU A 264
GLU A 361
ILE A 413
PRO A 368
 None
 0.86A 4xi3C-4h7nA:
undetectable		 4xi3C-4h7nA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		4 / 7 PHE A 434
ILE A 386
ASP A 234
GLY A 232
 GOL  A 504 ( 3.8A)
GOL  A 504 ( 4.4A)
None
None
 0.88A 5h3aA-4h7nA:
undetectable		 5h3aA-4h7nA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		3 / 3 ILE A 112
PRO A 113
ILE A 115
 None
 0.43A 5hw8F-4h7nA:
undetectable		 5hw8F-4h7nA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		5 / 12 LEU A  89
LEU A 179
TRP A  56
LEU A 183
PHE A  88
 None
 1.36A 5ieoA-4h7nA:
undetectable		 5ieoA-4h7nA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		5 / 12 PHE A 279
ILE A 269
ILE A 266
ILE A 415
ALA A 401
 None
 1.13A 5vceA-4h7nA:
undetectable		 5vceA-4h7nA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_A_ASCA501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		5 / 10 TYR A 270
ILE A 266
ARG A 268
ALA A 410
ILE A 237
 None
 1.19A 5zovA-4h7nA:
0.0		 5zovA-4h7nA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		5 / 12 TYR A 270
ILE A 266
ARG A 268
ALA A 410
ILE A 237
 None
 1.16A 5zovB-4h7nA:
undetectable		 5zovB-4h7nA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4h7n ALDEHYDE
DEHYDROGENASE
(Trichormus
variabilis) 		3 / 3 ASP A  74
SER A 140
SER A 131
 None
 0.54A 6mxtA-4h7nA:
undetectable		 6mxtA-4h7nA:
22.14