SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h7o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 12 LEU A 182
GLY A 217
GLY A 215
ILE A 202
LEU A 111
 None
 1.01A 1p91B-4h7oA:
undetectable		 1p91B-4h7oA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 12 GLY A 199
GLY A 217
GLU A 198
ILE A 176
VAL A 170
 None
 0.76A 2oxtB-4h7oA:
undetectable		 2oxtB-4h7oA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 12 ILE A 150
ALA A 148
ALA A 117
VAL A 174
ILE A 176
 None
 0.98A 3e00A-4h7oA:
undetectable		 3e00A-4h7oA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 11 GLY A 165
ALA A 168
ILE A 154
LEU A 156
ILE A 176
 CYS  A 301 ( 4.6A)
None
None
None
None
 1.10A 4dt8A-4h7oA:
undetectable		 4dt8A-4h7oA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 10 GLY A 165
ALA A 168
ILE A 154
LEU A 156
ILE A 176
 CYS  A 301 ( 4.6A)
None
None
None
None
 1.00A 4dt8B-4h7oA:
undetectable		 4dt8B-4h7oA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		4 / 4 ALA A  94
VAL A  95
ASP A  92
LEU A 105
 CYS  A 303 ( 3.7A)
None
CYS  A 303 (-2.9A)
None
 0.92A 4e7gA-4h7oA:
undetectable		 4e7gA-4h7oA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 12 LEU A 156
ILE A 202
ILE A 208
GLY A 183
ILE A 176
 None
None
None
CYS  A 301 ( 4.1A)
None
 0.96A 4q1yB-4h7oA:
undetectable		 4q1yB-4h7oA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		4 / 6 ARG A 115
ASP A 172
GLY A 153
ASP A  84
 None
 1.19A 5hp1A-4h7oA:
undetectable		 5hp1A-4h7oA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		4 / 6 PRO A 194
VAL A 170
VAL A 174
ILE A 208
 None
 0.87A 5pbeA-4h7oA:
undetectable		 5pbeA-4h7oA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		5 / 9 ALA A 206
VAL A 236
ALA A 241
SER A 224
VAL A 230
 None
 1.18A 6bklA-4h7oA:
undetectable
6bklB-4h7oA:
undetectable
6bklC-4h7oA:
undetectable
6bklD-4h7oA:
undetectable		 6bklA-4h7oA:
7.64
6bklB-4h7oA:
7.64
6bklC-4h7oA:
7.64
6bklD-4h7oA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		4 / 5 THR A 167
ARG A 192
THR A 130
GLN A 133
 None
CYS  A 301 (-3.8A)
None
None
 1.37A 6ectA-4h7oA:
undetectable		 6ectA-4h7oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 4h7o SERINE
ACETYLTRANSFERASE
(Vibrio
cholerae) 		4 / 5 THR A 167
ARG A 192
THR A 130
GLN A 133
 None
CYS  A 301 (-3.8A)
None
None
 1.45A 6ecxA-4h7oA:
undetectable		 6ecxA-4h7oA:
20.40