SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWI_A_115A2_2 (HMG-COA REDUCTASE)	4h7y	DUAL SPECIFICITY PROTEIN KINASE TTK (Homo sapiens)	4 / 8	GLU A 14 ASN A 57 LEU A 49 ALA A 45	None	1.05A	1hwiB-4h7yA: undetectable	1hwiB-4h7yA: 17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JFA_B_CCSB417_0 (ESTROGEN RECEPTOR)	4h7y	DUAL SPECIFICITY PROTEIN KINASE TTK (Homo sapiens)	3 / 3	GLN A 118 LYS A 112 VAL A 110	None	0.92A	2jfaB-4h7yA: undetectable	2jfaB-4h7yA: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_T_BEZT801_1 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	4h7y	DUAL SPECIFICITY PROTEIN KINASE TTK (Homo sapiens)	4 / 8	PHE A 60 ALA A 45 PRO A 13 LEU A 17	None	1.20A	5dzkF-4h7yA: undetectable 5dzkT-4h7yA: undetectable	5dzkF-4h7yA: 24.66 5dzkT-4h7yA: 5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UC1_B_486B801_2 (GLUCOCORTICOID RECEPTOR)	4h7y	DUAL SPECIFICITY PROTEIN KINASE TTK (Homo sapiens)	5 / 12	LEU A 35 ASN A 36 LEU A 38 GLY A 40 ARG A 66	None	0.82A	5uc1B-4h7yA: undetectable	5uc1B-4h7yA: 18.99

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HWI_A_115A2_2","HMG-COA REDUCTASE;HMG-COA REDUCTASE","4h7y","DUAL SPECIFICITY PROTEIN KINASE TTK","Homo sapiens",4,"GLU A  14;ASN A  57;LEU A  49;ALA A  45","None","1.05A","1hwiB-4h7yA:undetectable","1hwiB-4h7yA:17.38"],["2JFA_B_CCSB417_0","ESTROGEN RECEPTOR","4h7y","DUAL SPECIFICITY PROTEIN KINASE TTK","Homo sapiens",3,"GLN A 118;LYS A 112;VAL A 110","None","0.92A","2jfaB-4h7yA:undetectable","2jfaB-4h7yA:20.55"],["5DZK_T_BEZT801_1","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2;BEZ-LEU-LEU","4h7y","DUAL SPECIFICITY PROTEIN KINASE TTK","Homo sapiens",4,"PHE A  60;ALA A  45;PRO A  13;LEU A  17","None","1.20A","5dzkF-4h7yA:undetectable;5dzkT-4h7yA:undetectable","5dzkF-4h7yA:24.66;5dzkT-4h7yA:5.71"],["5UC1_B_486B801_2","GLUCOCORTICOID RECEPTOR","4h7y","DUAL SPECIFICITY PROTEIN KINASE TTK","Homo sapiens",5,"LEU A  35;ASN A  36;LEU A  38;GLY A  40;ARG A  66","None","0.82A","5uc1B-4h7yA:undetectable","5uc1B-4h7yA:18.99"]]