SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4h8a UREIDOGLYCOLATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 PHE A  67
ALA A  89
ALA A  85
VAL A  49
LEU A  33
 None
 1.31A 1hbpA-4h8aA:
undetectable		 1hbpA-4h8aA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4h8a UREIDOGLYCOLATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ALA A  97
LEU A 240
GLY A 134
LEU A 264
GLN A 263
 None
 1.09A 1qabF-4h8aA:
undetectable		 1qabF-4h8aA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 4h8a UREIDOGLYCOLATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ALA A  84
PHE A  67
ALA A  89
ALA A  85
LEU A  33
 None
 1.08A 1rbpA-4h8aA:
undetectable		 1rbpA-4h8aA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4h8a UREIDOGLYCOLATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 MET A 251
ILE A  12
LEU A 331
GLY A  45
SER A  43
 None
 1.29A 2ogyA-4h8aA:
undetectable		 2ogyA-4h8aA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 4h8a UREIDOGLYCOLATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 GLU A 277
GLN A 285
ARG A 288
 None
 0.84A 2w3bB-4h8aA:
undetectable		 2w3bB-4h8aA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4h8a UREIDOGLYCOLATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 SER A 249
ASP A 141
ASP A 254
 None
 0.78A 3iv6A-4h8aA:
undetectable		 3iv6A-4h8aA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4h8a UREIDOGLYCOLATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 PRO A 164
GLY A 131
SER A 276
ASN A 269
 None
 0.95A 3lslA-4h8aA:
undetectable
3lslD-4h8aA:
undetectable		 3lslA-4h8aA:
21.28
3lslD-4h8aA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 4h8a UREIDOGLYCOLATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ASP A 174
PHE A 123
SER A 117
LEU A  33
 NAI  A 401 (-2.7A)
None
NAI  A 401 ( 4.5A)
None
 1.01A 3m0wE-4h8aA:
undetectable
3m0wF-4h8aA:
undetectable
3m0wG-4h8aA:
undetectable
3m0wH-4h8aA:
undetectable		 3m0wE-4h8aA:
13.89
3m0wF-4h8aA:
13.89
3m0wG-4h8aA:
13.89
3m0wH-4h8aA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_B_ASDB126_1
(STEROID
DELTA-ISOMERASE)		 4h8a UREIDOGLYCOLATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 LEU A  33
PHE A 123
VAL A  32
MET A 114
ALA A  89
 None
 1.46A 3nuvB-4h8aA:
undetectable		 3nuvB-4h8aA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4h8a UREIDOGLYCOLATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 4 GLY A 227
GLY A 225
THR A 177
LEU A 159
 None
 0.87A 3si7C-4h8aA:
undetectable
3si7D-4h8aA:
undetectable		 3si7C-4h8aA:
22.63
3si7D-4h8aA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4h8a UREIDOGLYCOLATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ASN A 271
GLN A 102
ASN A 104
THR A 100
 None
 1.35A 4d1yA-4h8aA:
undetectable
4d1yB-4h8aA:
undetectable		 4d1yA-4h8aA:
21.10
4d1yB-4h8aA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4h8a UREIDOGLYCOLATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 MET A 251
ILE A  12
LEU A 331
GLY A  45
SER A  43
 None
 1.35A 4djfB-4h8aA:
undetectable		 4djfB-4h8aA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4h8a UREIDOGLYCOLATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ALA A 160
LEU A 159
LEU A 171
THR A 172
PRO A 305
 None
None
None
None
NAI  A 401 ( 4.7A)
 1.19A 5k9dA-4h8aA:
undetectable		 5k9dA-4h8aA:
21.84