SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 ARG A  84
ARG A 207
ARG A  46
 FPP  A 302 (-3.0A)
SO4  A 303 (-3.7A)
FPP  A 302 (-2.8A)
 0.88A 1l7fA-4h8eA:
undetectable		 1l7fA-4h8eA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 ARG A  84
ARG A 207
ARG A  46
 FPP  A 302 (-3.0A)
SO4  A 303 (-3.7A)
FPP  A 302 (-2.8A)
 0.88A 1l7hA-4h8eA:
undetectable		 1l7hA-4h8eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 4 LEU A 212
PRO A  25
ILE A  30
LEU A 199
 None
 1.12A 1ya4C-4h8eA:
undetectable		 1ya4C-4h8eA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 5 LEU A 104
PHE A  99
VAL A 114
ALA A 134
 None
FPP  A 302 (-3.8A)
None
None
 1.20A 2cizA-4h8eA:
undetectable		 2cizA-4h8eA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 ASP A  33
ARG A 201
ARG A  46
 MG  A 301 ( 2.6A)
SO4  A 303 (-3.5A)
FPP  A 302 (-2.8A)
 1.05A 3k37A-4h8eA:
undetectable		 3k37A-4h8eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 PRO A  96
ILE A 150
THR A 127
ILE A 128
 FPP  A 302 ( 3.8A)
None
None
None
 0.95A 3p50A-4h8eA:
undetectable		 3p50A-4h8eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 PRO A  96
ILE A 150
THR A 127
ILE A 128
 FPP  A 302 ( 3.8A)
None
None
None
 0.96A 3p50B-4h8eA:
undetectable		 3p50B-4h8eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 PRO A  96
ILE A 150
THR A 127
ILE A 128
 FPP  A 302 ( 3.8A)
None
None
None
 0.95A 3p50C-4h8eA:
undetectable		 3p50C-4h8eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 PRO A  96
ILE A 150
THR A 127
ILE A 128
 FPP  A 302 ( 3.8A)
None
None
None
 0.96A 3p50D-4h8eA:
undetectable		 3p50D-4h8eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 PRO A  96
ILE A 150
THR A 127
ILE A 128
 FPP  A 302 ( 3.8A)
None
None
None
 0.97A 3p50E-4h8eA:
undetectable		 3p50E-4h8eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 5 ASP A 232
ASP A  33
ASN A 224
GLU A 235
 None
MG  A 301 ( 2.6A)
None
None
 1.42A 3vywD-4h8eA:
undetectable		 3vywD-4h8eA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 8 ILE A 237
LEU A 236
VAL A  69
GLY A  68
 None
 0.85A 3w1wA-4h8eA:
2.9		 3w1wA-4h8eA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		5 / 9 THR A 116
ILE A 150
THR A  61
LEU A 107
LEU A 104
 None
 1.28A 4ze0A-4h8eA:
undetectable		 4ze0A-4h8eA:
17.66