SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h8n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		5 / 12 THR A 242
ALA A 236
GLU A 237
LEU A 235
LEU A 220
 None
None
None
None
NDP  A3001 ( 4.2A)
 1.09A 1errA-4h8nA:
undetectable		 1errA-4h8nA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF209_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		5 / 10 GLU A 270
LEU A 274
GLN A 245
GLU A 243
SER A 262
 None
None
None
None
NDP  A3001 (-2.6A)
 1.47A 1wrlE-4h8nA:
undetectable
1wrlF-4h8nA:
undetectable		 1wrlE-4h8nA:
14.33
1wrlF-4h8nA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		5 / 12 THR A 242
ALA A 236
GLU A 237
LEU A 235
LEU A 220
 None
None
None
None
NDP  A3001 ( 4.2A)
 1.11A 2jfaA-4h8nA:
undetectable		 2jfaA-4h8nA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		3 / 3 PHE A 214
PHE A 300
PHE A 304
 NDP  A3001 (-3.2A)
NDP  A3001 ( 4.9A)
None
 0.84A 2od9A-4h8nA:
undetectable		 2od9A-4h8nA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		3 / 3 PHE A 214
PHE A 300
PHE A 304
 NDP  A3001 (-3.2A)
NDP  A3001 ( 4.9A)
None
 0.84A 2qqgA-4h8nA:
undetectable		 2qqgA-4h8nA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		5 / 12 THR A 242
ALA A 236
GLU A 237
LEU A 235
LEU A 220
 None
None
None
None
NDP  A3001 ( 4.2A)
 1.09A 2qxsA-4h8nA:
undetectable		 2qxsA-4h8nA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		5 / 12 THR A 242
ALA A 236
GLU A 237
LEU A 235
LEU A 220
 None
None
None
None
NDP  A3001 ( 4.2A)
 1.16A 2qxsB-4h8nA:
undetectable		 2qxsB-4h8nA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		4 / 7 TYR A 118
VAL A 116
ILE A  83
ASP A 120
 None
 1.19A 3bu1A-4h8nA:
undetectable		 3bu1A-4h8nA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		4 / 6 THR A  59
ILE A  46
LEU A  42
THR A  65
 None
 0.90A 3deuB-4h8nA:
undetectable		 3deuB-4h8nA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		4 / 8 THR A  59
GLY A  24
LEU A  23
ILE A  46
 None
NDP  A3001 (-3.4A)
None
None
 0.85A 3nbqB-4h8nA:
undetectable		 3nbqB-4h8nA:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		5 / 12 TYR A  63
HIS A 125
SER A 126
ASN A 162
PHE A 299
 NDP  A3001 (-4.7A)
NDP  A3001 (-4.5A)
None
NDP  A3001 (-3.3A)
NDP  A3001 ( 4.2A)
 0.37A 3r43A-4h8nA:
31.0		 3r43A-4h8nA:
32.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		5 / 12 TYR A  63
HIS A 125
SER A 126
ASN A 162
PHE A 299
 NDP  A3001 (-4.7A)
NDP  A3001 (-4.5A)
None
NDP  A3001 (-3.3A)
NDP  A3001 ( 4.2A)
 0.29A 3r6iA-4h8nA:
31.2		 3r6iA-4h8nA:
32.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R7M_A_SUZA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		5 / 10 TYR A  63
HIS A 125
SER A 126
ASN A 162
PHE A 299
 NDP  A3001 (-4.7A)
NDP  A3001 (-4.5A)
None
NDP  A3001 (-3.3A)
NDP  A3001 ( 4.2A)
 0.39A 3r7mA-4h8nA:
31.1		 3r7mA-4h8nA:
32.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		5 / 12 TYR A  63
HIS A 125
SER A 126
ASN A 162
PHE A 299
 NDP  A3001 (-4.7A)
NDP  A3001 (-4.5A)
None
NDP  A3001 (-3.3A)
NDP  A3001 ( 4.2A)
 0.34A 3r94A-4h8nA:
31.2		 3r94A-4h8nA:
32.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		3 / 3 PHE A 203
GLN A 196
PHE A 172
 None
 0.79A 3rv5A-4h8nA:
undetectable		 3rv5A-4h8nA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		4 / 6 VAL A 259
ASP A  58
SER A 161
ALA A  62
 NDP  A3001 (-4.4A)
NDP  A3001 (-3.8A)
NDP  A3001 (-2.7A)
None
 1.20A 4nedA-4h8nA:
undetectable		 4nedA-4h8nA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		5 / 12 THR A 242
ALA A 236
GLU A 237
LEU A 235
LEU A 220
 None
None
None
None
NDP  A3001 ( 4.2A)
 1.06A 4xi3A-4h8nA:
undetectable		 4xi3A-4h8nA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		5 / 12 THR A 242
ALA A 236
GLU A 237
LEU A 235
LEU A 220
 None
None
None
None
NDP  A3001 ( 4.2A)
 1.09A 4xi3D-4h8nA:
undetectable		 4xi3D-4h8nA:
20.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		5 / 9 TYR A  63
HIS A 125
SER A 126
ASN A 162
PHE A 299
 NDP  A3001 (-4.7A)
NDP  A3001 (-4.5A)
None
NDP  A3001 (-3.3A)
NDP  A3001 ( 4.2A)
 0.37A 4yvvB-4h8nA:
30.8		 4yvvB-4h8nA:
33.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		3 / 3 THR A 261
THR A 260
PHE A 214
 NDP  A3001 (-4.0A)
NDP  A3001 (-3.4A)
NDP  A3001 (-3.2A)
 0.82A 5cxvA-4h8nA:
undetectable		 5cxvA-4h8nA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		4 / 8 GLU A  68
GLY A  70
GLN A 113
LEU A 114
 None
 0.89A 5sxqA-4h8nA:
undetectable		 5sxqA-4h8nA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		4 / 8 GLU A  68
GLY A  70
GLN A 113
LEU A 114
 None
 0.89A 5sxtA-4h8nA:
undetectable		 5sxtA-4h8nA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		4 / 8 GLU A  68
GLY A  70
GLN A 113
LEU A 114
 None
 0.88A 5sxtB-4h8nA:
undetectable		 5sxtB-4h8nA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		3 / 3 LYS A 238
LEU A 235
ARG A 234
 None
 0.82A 5yw0A-4h8nA:
undetectable		 5yw0A-4h8nA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 4h8n CONJUGATED
POLYKETONE REDUCTASE
C2
(Candida
parapsilosis) 		4 / 6 PHE A 304
ARG A 297
ILE A 200
ASN A 195
 None
 1.49A 6dhbA-4h8nA:
undetectable		 6dhbA-4h8nA:
17.96