SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4h8q IRON
TRANSPORT-ASSOCIATED
DOMAIN PROTEIN
(Bacillus
anthracis) 		5 / 10 VAL A  84
VAL A 101
VAL A  99
ILE A 116
LEU A  50
 None
HEM  A 201 (-4.8A)
HEM  A 201 (-4.5A)
None
None
 1.09A 1fe2A-4h8qA:
undetectable		 1fe2A-4h8qA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4h8q IRON
TRANSPORT-ASSOCIATED
DOMAIN PROTEIN
(Bacillus
anthracis) 		4 / 8 GLU A  87
ALA A  88
THR A  61
ILE A  46
 None
 0.79A 2dtjA-4h8qA:
undetectable
2dtjB-4h8qA:
undetectable		 2dtjA-4h8qA:
24.29
2dtjB-4h8qA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4h8q IRON
TRANSPORT-ASSOCIATED
DOMAIN PROTEIN
(Bacillus
anthracis) 		4 / 7 GLN A  60
THR A  61
THR A  29
MET A  26
 None
None
None
HEM  A 201 (-2.9A)
 1.10A 4mbsA-4h8qA:
undetectable		 4mbsA-4h8qA:
15.53