SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4h98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
PHE A  36
THR A  58
SER A  61
LEU A  69
ARG A  72
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
None
None
 1.13A 1ao8A-4h98A:
17.3		 1ao8A-4h98A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
PHE A  36
THR A  58
SER A  61
LEU A  69
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
None
14Q  A 302 (-4.2A)
 1.07A 1ao8A-4h98A:
17.3		 1ao8A-4h98A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ALA A  11
PHE A  36
THR A  58
LEU A  69
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
14Q  A 302 (-4.2A)
 0.88A 1bzfA-4h98A:
16.9		 1bzfA-4h98A:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
THR A  58
PRO A  63
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.56A 1cd2A-4h98A:
22.5		 1cd2A-4h98A:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
PRO A  63
PHE A  66
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.4A)
14Q  A 302 (-3.7A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.61A 1cd2A-4h98A:
22.5		 1cd2A-4h98A:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
14Q  A 302 (-4.2A)
 0.48A 1d1gA-4h98A:
16.5		 1d1gA-4h98A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
14Q  A 302 (-4.2A)
 0.54A 1d1gB-4h98A:
16.5		 1d1gB-4h98A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ARG A  37
ILE A  62
LEU A  69
ARG A  72
ILE A 121
 None
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
 1.16A 1d1gB-4h98A:
16.5		 1d1gB-4h98A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
THR A  58
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.70A 1ddrA-4h98A:
17.5		 1ddrA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.51A 1ddrB-4h98A:
17.8		 1ddrB-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.62A 1ddsA-4h98A:
17.6		 1ddsA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.56A 1ddsB-4h98A:
18.0		 1ddsB-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
PRO A  63
LEU A  69
ARG A  72
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 ( 4.0A)
None
 0.43A 1df7A-4h98A:
18.6		 1df7A-4h98A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ILE A   9
ALA A  11
PHE A  36
SER A  61
PRO A  63
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.4A)
14Q  A 302 ( 4.0A)
None
 0.48A 1dg5A-4h98A:
18.5		 1dg5A-4h98A:
27.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
PRO A  63
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 (-4.2A)
 0.49A 1dhfA-4h98A:
21.9		 1dhfA-4h98A:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.43A 1dhfB-4h98A:
22.0		 1dhfB-4h98A:
37.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.74A 1dhiA-4h98A:
17.8		 1dhiA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.52A 1dhiB-4h98A:
18.0		 1dhiB-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.60A 1dhjA-4h98A:
17.7		 1dhjA-4h98A:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
 0.71A 1dhjA-4h98A:
17.7		 1dhjA-4h98A:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
PRO A  70
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.71A 1dhjB-4h98A:
18.0		 1dhjB-4h98A:
27.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
GLU A  32
SER A  61
ILE A  62
PRO A  63
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
None
 0.57A 1dlsA-4h98A:
22.4		 1dlsA-4h98A:
37.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
GLU A  32
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
 0.69A 1draA-4h98A:
17.8		 1draA-4h98A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
GLU A  32
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.52A 1draB-4h98A:
18.1		 1draB-4h98A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.77A 1drbA-4h98A:
17.8		 1drbA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.55A 1drbB-4h98A:
18.0		 1drbB-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
PHE A  36
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.57A 1dreA-4h98A:
18.9		 1dreA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
SER A  61
ILE A  62
PRO A  63
LEU A  69
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
 0.75A 1drfA-4h98A:
21.6		 1drfA-4h98A:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
ILE A  62
PRO A  63
LEU A  69
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
 0.55A 1drfA-4h98A:
21.6		 1drfA-4h98A:
37.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.56A 1dyiA-4h98A:
17.8		 1dyiA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.45A 1dyiB-4h98A:
18.0		 1dyiB-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 11 ILE A   9
ALA A  11
LEU A  25
GLU A  32
PHE A  36
ILE A  62
PRO A  63
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.48A 1dyrA-4h98A:
22.3		 1dyrA-4h98A:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 10 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.52A 1j3jA-4h98A:
8.3		 1j3jA-4h98A:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 9 ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.40A 1j3jB-4h98A:
20.6		 1j3jB-4h98A:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.60A 1jolA-4h98A:
17.8		 1jolA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
PRO A  70
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.62A 1jolB-4h98A:
18.1		 1jolB-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.46A 1jomA-4h98A:
17.3		 1jomA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.46A 1qzfA-4h98A:
21.7		 1qzfA-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.49A 1qzfB-4h98A:
21.7		 1qzfB-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.49A 1qzfC-4h98A:
21.7		 1qzfC-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.49A 1qzfD-4h98A:
21.7		 1qzfD-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.51A 1qzfE-4h98A:
21.7		 1qzfE-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.39A 1ra2A-4h98A:
18.1		 1ra2A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.48A 1ra3A-4h98A:
18.0		 1ra3A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.39A 1ra8A-4h98A:
18.0		 1ra8A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.38A 1rb2A-4h98A:
18.0		 1rb2A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.40A 1rb2B-4h98A:
18.0		 1rb2B-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 10 ILE A   9
ALA A  11
ILE A  62
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.47A 1rb3A-4h98A:
18.2		 1rb3A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.71A 1rb3B-4h98A:
18.2		 1rb3B-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.49A 1rd7A-4h98A:
17.7		 1rd7A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.54A 1rd7B-4h98A:
17.4		 1rd7B-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.46A 1re7A-4h98A:
17.8		 1re7A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
PRO A  70
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.45A 1re7B-4h98A:
17.6		 1re7B-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
THR A  58
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.63A 1rg7A-4h98A:
17.1		 1rg7A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
PHE A  36
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.55A 1rh3A-4h98A:
18.9		 1rh3A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.41A 1rx2A-4h98A:
19.2		 1rx2A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.45A 1rx3A-4h98A:
19.2		 1rx3A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.47A 1rx7A-4h98A:
17.4		 1rx7A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
PRO A  70
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.45A 1rx8A-4h98A:
19.0		 1rx8A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
 0.66A 1tdrA-4h98A:
17.8		 1tdrA-4h98A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 10 ALA A  11
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.66A 1tdrB-4h98A:
18.1		 1tdrB-4h98A:
27.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
GLU A  32
PRO A  63
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.4A)
None
None
None
 0.44A 1u70A-4h98A:
22.0		 1u70A-4h98A:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
GLU A  32
SER A  61
PRO A  63
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.4A)
None
None
None
 0.63A 1u72A-4h98A:
22.3		 1u72A-4h98A:
37.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
LEU A  25
MET A  33
PHE A  36
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-4.0A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.50A 2bl9A-4h98A:
20.0		 2bl9A-4h98A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.62A 2blaA-4h98A:
19.7		 2blaA-4h98A:
27.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
LEU A  25
THR A  58
PRO A  63
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.50A 2cd2A-4h98A:
22.5		 2cd2A-4h98A:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
THR A  58
PRO A  63
PHE A  66
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.4A)
14Q  A 302 (-3.7A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.59A 2cd2A-4h98A:
22.5		 2cd2A-4h98A:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
PRO A  70
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.35A 2d0kA-4h98A:
17.5		 2d0kA-4h98A:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.43A 2d0kB-4h98A:
17.8		 2d0kB-4h98A:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
 0.67A 2drcA-4h98A:
17.8		 2drcA-4h98A:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.53A 2drcB-4h98A:
18.0		 2drcB-4h98A:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
 0.63A 2oipA-4h98A:
22.3		 2oipA-4h98A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
None
None
14Q  A 302 (-4.2A)
 0.59A 2oipB-4h98A:
20.6		 2oipB-4h98A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LYS A  34
PHE A  36
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
None
14Q  A 302 (-3.8A)
None
None
14Q  A 302 (-4.2A)
 1.17A 2oipB-4h98A:
20.6		 2oipB-4h98A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
None
None
14Q  A 302 (-4.2A)
 0.59A 2oipC-4h98A:
22.0		 2oipC-4h98A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
 0.66A 2oipD-4h98A:
9.8		 2oipD-4h98A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
 0.72A 2oipE-4h98A:
21.4		 2oipE-4h98A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
GLU A  32
ILE A  62
LEU A  69
PRO A  70
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
None
None
 0.67A 2qk8A-4h98A:
18.9		 2qk8A-4h98A:
29.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 11 ILE A   9
ALA A  11
GLU A  32
PHE A  36
THR A  58
ILE A  62
PRO A  63
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 (-4.2A)
 0.43A 2w3aA-4h98A:
22.0		 2w3aA-4h98A:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 10 ILE A   9
ALA A  11
GLU A  32
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.46A 2w3aB-4h98A:
21.9		 2w3aB-4h98A:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
PRO A  63
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 (-4.2A)
 0.51A 2w3bA-4h98A:
21.9		 2w3bA-4h98A:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
ILE A  62
PRO A  63
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 (-4.2A)
 0.50A 2w3bB-4h98A:
22.0		 2w3bB-4h98A:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
ILE A  62
PRO A  63
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 (-4.2A)
 0.52A 2w3mA-4h98A:
21.7		 2w3mA-4h98A:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
LEU A  25
GLU A  32
PHE A  36
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
None
None
None
14Q  A 302 (-4.2A)
 0.51A 2w3mB-4h98A:
21.9		 2w3mB-4h98A:
38.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
PHE A  36
SER A  61
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.62A 2w3vA-4h98A:
19.1		 2w3vA-4h98A:
30.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 ALA A  11
LEU A  25
SER A  61
ILE A  62
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.2A)
 0.58A 2w9gA-4h98A:
19.5		 2w9gA-4h98A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 ALA A  11
LEU A  25
SER A  61
ILE A  62
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.2A)
 0.81A 2w9hA-4h98A:
19.1		 2w9hA-4h98A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ILE A   9
ALA A  11
LEU A  25
SER A  61
ILE A  62
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.56A 2w9sA-4h98A:
19.4		 2w9sA-4h98A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ILE A   9
ALA A  11
LEU A  25
SER A  61
ILE A  62
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.56A 2w9sB-4h98A:
19.3		 2w9sB-4h98A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 10 ILE A   9
ALA A  11
LEU A  25
SER A  61
ILE A  62
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.55A 2w9sC-4h98A:
19.4		 2w9sC-4h98A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 10 ILE A   9
ALA A  11
LEU A  25
SER A  61
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
None
14Q  A 302 (-4.2A)
 0.74A 2w9sD-4h98A:
18.8		 2w9sD-4h98A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 8 ILE A   9
ALA A  11
LEU A  25
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
None
14Q  A 302 (-4.2A)
 0.61A 2w9sE-4h98A:
18.8		 2w9sE-4h98A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 10 ILE A   9
ALA A  11
LEU A  25
SER A  61
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
None
14Q  A 302 (-4.2A)
 0.74A 2w9sF-4h98A:
18.8		 2w9sF-4h98A:
31.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
GLU A  32
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.52A 2zzaA-4h98A:
19.5		 2zzaA-4h98A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
ALA A  11
GLU A  32
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.50A 2zzaB-4h98A:
19.5		 2zzaB-4h98A:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
LEU A  25
GLU A  32
PRO A  63
PHE A  66
LEU A  69
ARG A  72
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.4A)
14Q  A 302 (-3.7A)
None
None
14Q  A 302 ( 4.0A)
None
 0.53A 3cd2A-4h98A:
22.5		 3cd2A-4h98A:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
MET A  33
THR A  58
PRO A  63
PHE A  66
LEU A  69
PRO A  70
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.4A)
14Q  A 302 (-3.7A)
None
None
None
 1.10A 3cl9A-4h98A:
19.3		 3cl9A-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ALA A  11
THR A  58
SER A  61
PRO A  63
PHE A  66
LEU A  69
PRO A  70
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.4A)
14Q  A 302 (-3.7A)
None
None
None
None
 0.79A 3cl9A-4h98A:
19.3		 3cl9A-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ALA A  11
ILE A  62
PRO A  63
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.55A 3clbA-4h98A:
19.7		 3clbA-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 11 MET A  33
ILE A  62
PRO A  63
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.0A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
 0.94A 3clbA-4h98A:
19.7		 3clbA-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
MET A  33
PHE A  36
THR A  58
ILE A  62
PHE A  66
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-3.7A)
14Q  A 302 ( 4.0A)
None
 0.87A 3clbB-4h98A:
19.0		 3clbB-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
MET A  33
PHE A  36
THR A  58
SER A  61
ILE A  62
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
 0.87A 3clbB-4h98A:
19.0		 3clbB-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
THR A  58
ILE A  62
PRO A  63
PHE A  66
TYR A 127
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
14Q  A 302 (-3.7A)
None
 0.77A 3clbB-4h98A:
19.0		 3clbB-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
THR A  58
SER A  61
ILE A  62
PRO A  63
TYR A 127
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
 0.91A 3clbB-4h98A:
19.0		 3clbB-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
MET A  33
THR A  58
ILE A  62
PRO A  63
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
 0.82A 3clbC-4h98A:
19.8		 3clbC-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
THR A  58
ILE A  62
PRO A  63
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.52A 3clbC-4h98A:
19.8		 3clbC-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 10 ALA A  11
MET A  33
ILE A  62
PRO A  63
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.85A 3clbD-4h98A:
19.7		 3clbD-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
GLU A  32
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
None
 0.74A 3datA-4h98A:
18.9		 3datA-4h98A:
29.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
None
 0.41A 3dauA-4h98A:
19.2		 3dauA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ALA A  11
LEU A  25
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
None
None
14Q  A 302 (-4.2A)
 0.60A 3dfrA-4h98A:
19.1		 3dfrA-4h98A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ALA A  11
LEU A  25
PRO A  63
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-4.4A)
None
14Q  A 302 (-4.2A)
 0.77A 3dfrA-4h98A:
19.1		 3dfrA-4h98A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ALA A  11
LEU A  25
SER A  61
LEU A  69
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
None
14Q  A 302 (-4.2A)
 0.65A 3dfrA-4h98A:
19.1		 3dfrA-4h98A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ALA A  11
LEU A  25
SER A  61
PRO A  63
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.4A)
14Q  A 302 (-4.2A)
 0.56A 3dfrA-4h98A:
19.1		 3dfrA-4h98A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
 0.69A 3drcA-4h98A:
17.8		 3drcA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.51A 3drcB-4h98A:
18.0		 3drcB-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
LEU A  25
GLU A  32
SER A  61
PRO A  63
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.4A)
None
None
None
 0.78A 3eigA-4h98A:
21.1		 3eigA-4h98A:
37.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 ALA A  11
LEU A  25
GLU A  32
LEU A  69
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
None
None
 1.00A 3fl9A-4h98A:
18.7		 3fl9A-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 LEU A  25
GLU A  32
ILE A  62
LEU A  69
TYR A 127
 14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
 1.12A 3fl9A-4h98A:
18.7		 3fl9A-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
ASN A  24
LEU A  25
GLU A  32
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
None
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
None
14Q  A 302 (-4.2A)
 0.81A 3fl9B-4h98A:
18.1		 3fl9B-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
GLU A  32
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
None
None
14Q  A 302 (-4.2A)
 0.81A 3fl9B-4h98A:
18.1		 3fl9B-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 LEU A  25
GLU A  32
ILE A  62
LEU A  69
TYR A 127
 14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
 1.00A 3fl9B-4h98A:
18.1		 3fl9B-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 9 ALA A  11
LEU A  25
GLU A  32
ILE A  62
LEU A  69
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
 0.90A 3fl9D-4h98A:
19.0		 3fl9D-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 10 ALA A  11
LEU A  25
GLU A  32
ILE A  62
LEU A  69
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.96A 3fl9E-4h98A:
18.6		 3fl9E-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
GLU A  32
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
None
None
14Q  A 302 (-4.2A)
 0.87A 3fl9G-4h98A:
18.7		 3fl9G-4h98A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 LEU A  25
GLU A  32
ILE A  62
LEU A  69
TYR A 127
 14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
None
 1.02A 3fl9G-4h98A:
18.7		 3fl9G-4h98A:
29.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 11 ALA A  11
LEU A  25
SER A  61
ILE A  62
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.58A 3frbX-4h98A:
19.3		 3frbX-4h98A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 9 ALA A  11
LEU A  25
SER A  61
ILE A  62
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.2A)
 0.57A 3freX-4h98A:
19.4		 3freX-4h98A:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 10 ALA A  11
MET A  33
ILE A  62
PRO A  63
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
 0.82A 3hbbA-4h98A:
19.7		 3hbbA-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 9 ALA A  11
THR A  58
SER A  61
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 ( 4.0A)
None
 0.57A 3hbbB-4h98A:
19.1		 3hbbB-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ALA A  11
ILE A  62
PRO A  63
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.54A 3hbbC-4h98A:
19.6		 3hbbC-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 11 MET A  33
ILE A  62
PRO A  63
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.0A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
 0.89A 3hbbC-4h98A:
19.6		 3hbbC-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 10 ALA A  11
MET A  33
ILE A  62
PRO A  63
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.83A 3hbbD-4h98A:
19.7		 3hbbD-4h98A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.70A 3hj3A-4h98A:
22.8		 3hj3A-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
 0.63A 3hj3B-4h98A:
22.8		 3hj3B-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
None
None
14Q  A 302 (-4.2A)
 0.63A 3hj3C-4h98A:
9.6		 3hj3C-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
 0.56A 3hj3D-4h98A:
9.6		 3hj3D-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
 0.71A 3hj3D-4h98A:
9.6		 3hj3D-4h98A:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
GLU A  32
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.69A 3ia4A-4h98A:
19.3		 3ia4A-4h98A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		4 / 4 ILE A   9
PHE A  36
ILE A 121
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 ( 4.0A)
14Q  A 302 (-4.2A)
 0.28A 3ia4A-4h98A:
19.3		 3ia4A-4h98A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
GLU A  32
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.67A 3ia4B-4h98A:
19.3		 3ia4B-4h98A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
GLU A  32
PHE A  36
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.64A 3ia4C-4h98A:
19.3		 3ia4C-4h98A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
GLU A  32
PHE A  36
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.62A 3ia4D-4h98A:
19.3		 3ia4D-4h98A:
32.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
LEU A  25
GLU A  32
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
None
None
14Q  A 302 (-4.2A)
 0.68A 3ix9A-4h98A:
19.8		 3ix9A-4h98A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
LEU A  25
GLU A  32
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
None
None
14Q  A 302 (-4.2A)
 0.65A 3ix9B-4h98A:
19.8		 3ix9B-4h98A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 10 ALA A  11
GLU A  32
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.62A 3jw3A-4h98A:
19.3		 3jw3A-4h98A:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 ALA A  11
GLU A  32
ILE A  62
LEU A  69
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 1.01A 3jw3A-4h98A:
19.3		 3jw3A-4h98A:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 9 ALA A  11
LEU A  25
GLU A  32
ILE A  62
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
 0.61A 3jw3B-4h98A:
19.4		 3jw3B-4h98A:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 9 ALA A  11
LEU A  25
GLU A  32
ILE A  62
LEU A  69
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
 0.88A 3jw3B-4h98A:
19.4		 3jw3B-4h98A:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 11 ALA A  11
ASN A  24
LEU A  25
GLU A  32
ILE A  62
THR A 140
 14Q  A 302 ( 3.4A)
None
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.2A)
 0.68A 3jw5A-4h98A:
19.3		 3jw5A-4h98A:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 10 ALA A  11
LEU A  25
GLU A  32
ILE A  62
LEU A  69
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.68A 3jw5B-4h98A:
19.3		 3jw5B-4h98A:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
ARG A  37
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
None
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
 0.75A 3k2hA-4h98A:
21.0		 3k2hA-4h98A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ALA A  11
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
None
 0.68A 3k2hB-4h98A:
9.9		 3k2hB-4h98A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.53A 3k2hB-4h98A:
9.9		 3k2hB-4h98A:
18.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 11 ILE A   9
ALA A  11
GLU A  32
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.48A 3n0hA-4h98A:
22.3		 3n0hA-4h98A:
38.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
ARG A  37
THR A  58
ILE A  62
PRO A  63
THR A 140
 14Q  A 302 ( 3.4A)
None
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
14Q  A 302 (-4.2A)
 0.50A 3nrrA-4h98A:
20.3		 3nrrA-4h98A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
ARG A  37
THR A  58
ILE A  62
PRO A  63
THR A 140
 14Q  A 302 ( 3.4A)
None
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
14Q  A 302 (-4.2A)
 0.53A 3nrrB-4h98A:
21.1		 3nrrB-4h98A:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 12 ALA A  11
MET A  33
THR A  58
SER A  61
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
 1.18A 3qfxA-4h98A:
20.4		 3qfxA-4h98A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
PHE A  36
THR A  58
SER A  61
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.53A 3qfxA-4h98A:
20.4		 3qfxA-4h98A:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
PHE A  36
THR A  58
SER A  61
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.53A 3qfxB-4h98A:
20.4		 3qfxB-4h98A:
31.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 ALA A  11
MET A  33
SER A  61
ILE A  62
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.2A)
 0.97A 3qg2A-4h98A:
20.3		 3qg2A-4h98A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 10 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.49A 3qg2A-4h98A:
20.3		 3qg2A-4h98A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
ALA A  11
MET A  33
PHE A  36
SER A  61
ILE A  62
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.0A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
14Q  A 302 (-4.2A)
 0.48A 3qg2B-4h98A:
20.6		 3qg2B-4h98A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 10 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.47A 3qgtA-4h98A:
20.4		 3qgtA-4h98A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 10 ILE A   9
ALA A  11
PHE A  36
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.37A 3qgtB-4h98A:
20.7		 3qgtB-4h98A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.44A 3ql0A-4h98A:
19.1		 3ql0A-4h98A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
ILE A  62
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.41A 3ql3A-4h98A:
19.3		 3ql3A-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
GLU A  32
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.51A 3s3vA-4h98A:
22.1		 3s3vA-4h98A:
38.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 9 ILE A   9
ALA A  11
LEU A  25
PHE A  36
SER A  61
ILE A  62
ILE A 121
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
14Q  A 302 (-4.2A)
 0.47A 3tq8A-4h98A:
20.2		 3tq8A-4h98A:
32.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
LEU A  25
SER A  61
ILE A  62
LEU A  69
ARG A  72
ILE A 121
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
14Q  A 302 (-4.2A)
 0.58A 3tq9A-4h98A:
19.6		 3tq9A-4h98A:
32.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ALA A  11
LEU A  25
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 121
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
14Q  A 302 (-4.2A)
 0.49A 3tqbA-4h98A:
19.2		 3tqbA-4h98A:
32.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 10 ILE A   9
PHE A  36
THR A  58
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.40A 3um5A-4h98A:
20.3		 3um5A-4h98A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 VAL A  10
PHE A  36
THR A  58
SER A  61
ILE A  62
 NDP  A 301 ( 3.8A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
 1.39A 3um5A-4h98A:
20.3		 3um5A-4h98A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 10 ILE A   9
PHE A  36
THR A  58
SER A  61
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.42A 3um5B-4h98A:
20.6		 3um5B-4h98A:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ALA A  11
GLU A  32
PHE A  36
THR A  58
PHE A  66
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-3.7A)
None
None
None
14Q  A 302 (-4.2A)
 0.67A 4cd2A-4h98A:
21.6		 4cd2A-4h98A:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
GLU A  32
PHE A  36
THR A  58
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
None
None
14Q  A 302 (-4.2A)
 0.49A 4cd2A-4h98A:
21.6		 4cd2A-4h98A:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
THR A  58
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.75A 4dfrA-4h98A:
17.7		 4dfrA-4h98A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.55A 4dfrB-4h98A:
18.0		 4dfrB-4h98A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
PHE A  36
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
None
None
14Q  A 302 (-4.2A)
 0.59A 4eckA-4h98A:
19.0		 4eckA-4h98A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
PHE A  36
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
None
None
14Q  A 302 (-4.2A)
 0.79A 4eckB-4h98A:
18.9		 4eckB-4h98A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.46A 4ej1A-4h98A:
17.6		 4ej1A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.47A 4ej1B-4h98A:
17.5		 4ej1B-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.48A 4fhbA-4h98A:
18.2		 4fhbA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 10 ILE A   9
ALA A  11
LEU A  25
GLU A  32
PHE A  36
SER A  61
PRO A  63
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.8A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.4A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.50A 4g8zX-4h98A:
22.4		 4g8zX-4h98A:
34.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
PRO A  63
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
None
 0.54A 4gh8A-4h98A:
19.7		 4gh8A-4h98A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
PRO A  63
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
 0.57A 4gh8B-4h98A:
19.8		 4gh8B-4h98A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.47A 4i13A-4h98A:
17.5		 4i13A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ILE A   9
ALA A  11
PHE A  36
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
None
None
None
14Q  A 302 (-4.2A)
 0.34A 4i1nA-4h98A:
17.6		 4i1nA-4h98A:
27.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.51A 4kebB-4h98A:
21.9		 4kebB-4h98A:
37.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
ILE A  62
PRO A  63
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 (-4.2A)
 0.51A 4kfjB-4h98A:
21.9		 4kfjB-4h98A:
37.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.40A 4kjjA-4h98A:
18.3		 4kjjA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.44A 4kjkA-4h98A:
18.9		 4kjkA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.41A 4kjlA-4h98A:
18.8		 4kjlA-4h98A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 10 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.53A 4km0A-4h98A:
17.4		 4km0A-4h98A:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.51A 4km0B-4h98A:
17.7		 4km0B-4h98A:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.45A 4km2A-4h98A:
17.9		 4km2A-4h98A:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
PHE A  36
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.47A 4km2B-4h98A:
17.4		 4km2B-4h98A:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
PHE A  36
THR A  58
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.52A 4km2B-4h98A:
17.4		 4km2B-4h98A:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
SER A  61
ILE A  62
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.64A 4ky8A-4h98A:
16.0		 4ky8A-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
SER A  61
ILE A  62
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.70A 4ky8B-4h98A:
16.9		 4ky8B-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
SER A  61
ILE A  62
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.67A 4ky8C-4h98A:
22.7		 4ky8C-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
SER A  61
ILE A  62
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.70A 4ky8D-4h98A:
19.3		 4ky8D-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
SER A  61
ILE A  62
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.72A 4ky8E-4h98A:
22.7		 4ky8E-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 11 ALA A  11
THR A  58
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
None
None
14Q  A 302 (-4.2A)
 0.36A 4kyaA-4h98A:
20.9		 4kyaA-4h98A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 11 ALA A  11
THR A  58
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
None
None
14Q  A 302 (-4.2A)
 0.38A 4kyaE-4h98A:
20.8		 4kyaE-4h98A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 11 ALA A  11
THR A  58
LEU A  69
ARG A  72
THR A 140
 14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
None
None
14Q  A 302 (-4.2A)
 0.34A 4kyaG-4h98A:
20.8		 4kyaG-4h98A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
PHE A  36
PRO A  63
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
 0.50A 4m2xA-4h98A:
18.3		 4m2xA-4h98A:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
PRO A  63
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.48A 4m2xC-4h98A:
18.2		 4m2xC-4h98A:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ILE A   9
ALA A  11
PRO A  63
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.4A)
None
14Q  A 302 ( 4.0A)
None
 0.47A 4m2xE-4h98A:
18.0		 4m2xE-4h98A:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ILE A   9
ALA A  11
PRO A  63
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.4A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.39A 4m2xG-4h98A:
18.4		 4m2xG-4h98A:
27.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		10 / 12 ILE A   9
ALA A  11
LEU A  25
PHE A  36
THR A  58
ILE A  62
PRO A  63
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 (-4.4A)
None
None
14Q  A 302 (-4.2A)
 0.48A 4m6kA-4h98A:
22.3		 4m6kA-4h98A:
38.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.41A 4nx6A-4h98A:
19.3		 4nx6A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.46A 4nx7A-4h98A:
19.4		 4nx7A-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
PRO A  70
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
 0.48A 4p3qA-4h98A:
19.3		 4p3qA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.45A 4p3rA-4h98A:
19.4		 4p3rA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ILE A   9
ALA A  11
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.29A 4p66A-4h98A:
19.3		 4p66A-4h98A:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
PHE A  36
SER A  61
ILE A  62
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 (-3.8A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.35A 4p68A-4h98A:
19.1		 4p68A-4h98A:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
 0.48A 4pssA-4h98A:
undetectable		 4pssA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.48A 4pstA-4h98A:
undetectable		 4pstA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.48A 4psyA-4h98A:
19.3		 4psyA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.45A 4pthA-4h98A:
19.1		 4pthA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.38A 4ptjA-4h98A:
19.5		 4ptjA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.60A 4q0dA-4h98A:
23.1		 4q0dA-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.60A 4q0dB-4h98A:
23.1		 4q0dB-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
None
None
None
14Q  A 302 (-4.2A)
 0.59A 4q0dC-4h98A:
8.8		 4q0dC-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
SER A  61
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
None
None
14Q  A 302 (-4.2A)
 0.66A 4q0dC-4h98A:
8.8		 4q0dC-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
None
None
None
14Q  A 302 (-4.2A)
 0.60A 4q0dD-4h98A:
23.1		 4q0dD-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ALA A  11
LEU A  25
SER A  61
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-2.6A)
None
None
14Q  A 302 (-4.2A)
 0.67A 4q0dD-4h98A:
23.1		 4q0dD-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ALA A  11
LEU A  25
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.1A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.60A 4q0dE-4h98A:
23.1		 4q0dE-4h98A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.67A 4qi9A-4h98A:
17.3		 4qi9A-4h98A:
29.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.65A 4qi9B-4h98A:
17.6		 4qi9B-4h98A:
29.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.69A 4qi9C-4h98A:
17.0		 4qi9C-4h98A:
29.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.48A 4qleA-4h98A:
18.3		 4qleA-4h98A:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.70A 4qleB-4h98A:
18.2		 4qleB-4h98A:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 11 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.50A 4qlfA-4h98A:
15.5		 4qlfA-4h98A:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.44A 4qlgA-4h98A:
18.4		 4qlgA-4h98A:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.51A 4qlgB-4h98A:
18.0		 4qlgB-4h98A:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.42A 4rgcA-4h98A:
19.4		 4rgcA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.40A 4x5fA-4h98A:
18.0		 4x5fA-4h98A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.40A 4x5fB-4h98A:
18.3		 4x5fB-4h98A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.47A 4x5gA-4h98A:
18.0		 4x5gA-4h98A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
THR A  58
ILE A  62
LEU A  69
ARG A  72
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.46A 4x5gB-4h98A:
18.3		 4x5gB-4h98A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.50A 4x5hA-4h98A:
17.9		 4x5hA-4h98A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.50A 4x5iA-4h98A:
17.9		 4x5iA-4h98A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.49A 4x5jA-4h98A:
17.9		 4x5jA-4h98A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		4 / 6 TYR A  35
GLY A 199
SER A 170
LEU A 173
 None
 1.02A 5bphA-4h98A:
undetectable		 5bphA-4h98A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		4 / 7 TYR A  35
GLY A 199
SER A 170
LEU A 173
 None
 1.12A 5bphB-4h98A:
undetectable		 5bphB-4h98A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		4 / 4 TYR A  35
GLY A 199
SER A 170
LEU A 173
 None
 1.08A 5bphC-4h98A:
undetectable		 5bphC-4h98A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.60A 5e8qA-4h98A:
11.2		 5e8qA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.58A 5e8qB-4h98A:
18.0		 5e8qB-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.60A 5eajA-4h98A:
17.7		 5eajA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
PRO A  70
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.66A 5eajB-4h98A:
18.1		 5eajB-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.73A 5hi6A-4h98A:
18.2		 5hi6A-4h98A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 12 ILE A   9
ALA A  11
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.73A 5hi6B-4h98A:
18.3		 5hi6B-4h98A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		6 / 12 ILE A   9
SER A  61
ILE A  62
LEU A  69
ARG A  72
TYR A 127
 14Q  A 302 (-4.1A)
14Q  A 302 (-2.6A)
14Q  A 302 (-4.2A)
None
None
None
 0.77A 5hi6B-4h98A:
18.3		 5hi6B-4h98A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 8 ILE A   9
ALA A  11
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.20A 5uihA-4h98A:
17.0		 5uihA-4h98A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.60A 5ujxA-4h98A:
11.3		 5ujxA-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
None
14Q  A 302 (-4.2A)
 0.60A 5ujxB-4h98A:
18.0		 5ujxB-4h98A:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		8 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
ARG A  72
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
None
14Q  A 302 (-4.2A)
 0.41A 5z6fA-4h98A:
19.3		 5z6fA-4h98A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.45A 5z6jA-4h98A:
19.4		 5z6jA-4h98A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.50A 5z6kA-4h98A:
19.3		 5z6kA-4h98A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 9 ILE A   9
ALA A  11
ILE A  62
PRO A  70
ARG A  72
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-4.2A)
None
None
 0.49A 5z6lA-4h98A:
19.1		 5z6lA-4h98A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		7 / 11 ILE A   9
ALA A  11
PHE A  36
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.48A 5z6mA-4h98A:
18.4		 5z6mA-4h98A:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 ALA A  11
PHE A  36
THR A  58
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
14Q  A 302 (-4.2A)
 0.42A 6aogA-4h98A:
20.8		 6aogA-4h98A:
37.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		5 / 10 ALA A  11
PHE A  36
THR A  58
TYR A 127
THR A 140
 14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
None
14Q  A 302 (-4.2A)
 0.43A 6aogB-4h98A:
20.7		 6aogB-4h98A:
37.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4h98 DIHYDROFOLATE
REDUCTASE
([Candida]
glabrata) 		9 / 12 ILE A   9
ALA A  11
PHE A  36
THR A  58
ILE A  62
LEU A  69
ILE A 121
TYR A 127
THR A 140
 14Q  A 302 (-4.1A)
14Q  A 302 ( 3.4A)
14Q  A 302 (-3.8A)
NDP  A 301 (-3.5A)
14Q  A 302 (-4.2A)
None
14Q  A 302 ( 4.0A)
None
14Q  A 302 (-4.2A)
 0.49A 7dfrA-4h98A:
19.1		 7dfrA-4h98A:
27.23