SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ha6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		4 / 6 GLY A 425
LEU A 430
TYR A 316
GLU A 175
 None
 0.99A 1fduD-4ha6A:
4.2		 1fduD-4ha6A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 12 ALA A  33
GLY A  26
GLY A  98
LEU A 216
HIS A 506
 None
FAD  A 601 (-3.2A)
CME  A 102 ( 3.4A)
None
FAD  A 601 (-4.6A)
 0.91A 1ya4A-4ha6A:
undetectable		 1ya4A-4ha6A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 11 ILE A 389
GLU A 271
GLY A 395
GLY A 391
GLU A 393
 GOL  A 603 ( 4.7A)
GOL  A 603 ( 2.8A)
None
None
None
 1.34A 2fn1A-4ha6A:
undetectable		 2fn1A-4ha6A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 11 ILE A 389
GLU A 271
GLY A 395
GLY A 391
GLU A 393
 GOL  A 603 ( 4.7A)
GOL  A 603 ( 2.8A)
None
None
None
 1.34A 2fn1B-4ha6A:
undetectable		 2fn1B-4ha6A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 12 MET A 109
PRO A 504
ALA A 176
ALA A 172
GLN A 328
 PXM  A 609 ( 4.8A)
FAD  A 601 (-4.3A)
None
None
PXM  A 609 ( 3.9A)
 1.29A 2jjpA-4ha6A:
undetectable		 2jjpA-4ha6A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 10 SER A 279
ILE A 281
ILE A 301
LEU A 483
ILE A 263
 None
 1.22A 2nnhB-4ha6A:
undetectable		 2nnhB-4ha6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 12 SER A  30
GLY A  24
GLY A  25
ALA A 212
GLY A  50
 None
FAD  A 601 (-3.2A)
FAD  A 601 ( 4.6A)
CME  A 102 ( 3.8A)
None
 0.69A 2pkkA-4ha6A:
2.9		 2pkkA-4ha6A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 12 SER A  30
GLY A  24
GLY A  25
ALA A 212
GLY A  50
 None
FAD  A 601 (-3.2A)
FAD  A 601 ( 4.6A)
CME  A 102 ( 3.8A)
None
 0.71A 2pkmA-4ha6A:
3.6		 2pkmA-4ha6A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 12 LEU A 270
GLY A 268
ALA A 494
SER A 386
GLY A 385
 None
FAD  A 601 (-3.6A)
FAD  A 601 (-3.6A)
None
None
 1.04A 2vmyA-4ha6A:
undetectable		 2vmyA-4ha6A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 12 LEU A 510
HIS A 506
SER A 101
PRO A 158
VAL A 209
 None
FAD  A 601 (-4.6A)
CME  A 102 ( 4.1A)
None
None
 1.43A 2xpwA-4ha6A:
undetectable		 2xpwA-4ha6A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 12 GLY A  24
GLY A  26
SER A  27
LEU A  32
ALA A  49
 FAD  A 601 (-3.2A)
FAD  A 601 (-3.2A)
FAD  A 601 (-2.8A)
None
FAD  A 601 (-3.6A)
 1.01A 2yvlA-4ha6A:
3.1		 2yvlA-4ha6A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		3 / 3 TYR A 335
ASP A 115
HIS A 462
 None
None
PXM  A 609 (-3.8A)
 0.87A 3e23A-4ha6A:
2.1		 3e23A-4ha6A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 9 ARG A 397
ALA A 274
GLY A 302
LEU A 305
ILE A 389
 None
GOL  A 603 (-3.5A)
None
None
GOL  A 603 ( 4.7A)
 1.16A 3em4B-4ha6A:
undetectable		 3em4B-4ha6A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 12 PRO A 463
LEU A 500
LEU A 305
ILE A 505
SER A 495
 None
None
None
FAD  A 601 (-4.4A)
None
 1.45A 3iltB-4ha6A:
undetectable
3iltE-4ha6A:
undetectable		 3iltB-4ha6A:
17.19
3iltE-4ha6A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 10 ILE A 505
SER A 495
PRO A 463
LEU A 500
LEU A 305
 FAD  A 601 (-4.4A)
None
None
None
None
 1.49A 3iltB-4ha6A:
undetectable
3iltE-4ha6A:
undetectable		 3iltB-4ha6A:
17.19
3iltE-4ha6A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		4 / 8 ASN A 199
HIS A 188
ASN A 189
ILE A 159
 None
 1.30A 3kp6A-4ha6A:
undetectable
3kp6B-4ha6A:
undetectable		 3kp6A-4ha6A:
12.92
3kp6B-4ha6A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		4 / 7 ILE A  20
ILE A  22
LEU A  36
SER A  37
 None
 0.67A 3r9vA-4ha6A:
undetectable
3r9vB-4ha6A:
undetectable		 3r9vA-4ha6A:
17.72
3r9vB-4ha6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 9 ALA A 211
GLY A  98
LEU A  46
LEU A 216
ILE A 228
 None
CME  A 102 ( 3.4A)
None
None
None
 1.18A 3wdmC-4ha6A:
undetectable		 3wdmC-4ha6A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 12 ARG A 416
GLU A 412
LEU A 405
ARG A 411
ALA A 454
 None
 1.47A 4cpzD-4ha6A:
undetectable		 4cpzD-4ha6A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 12 GLU A 165
VAL A 166
PRO A 198
THR A 197
HIS A 151
 None
 1.48A 4k88A-4ha6A:
undetectable		 4k88A-4ha6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 12 LEU A 275
CYH A 266
VAL A  21
LEU A 247
SER A 279
 FAD  A 601 ( 4.8A)
None
None
None
None
 1.42A 4ot2A-4ha6A:
2.4		 4ot2A-4ha6A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		4 / 5 ASP A 410
LEU A 405
ARG A  87
THR A 382
 None
 1.37A 4p3qA-4ha6A:
undetectable		 4p3qA-4ha6A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 9 VAL A 491
GLY A 268
ALA A 269
THR A 466
ILE A 505
 None
FAD  A 601 (-3.6A)
None
None
FAD  A 601 (-4.4A)
 1.09A 4r21B-4ha6A:
undetectable		 4r21B-4ha6A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 11 LEU A 483
ARG A 482
LEU A 489
LEU A 276
LEU A 265
 None
 1.09A 4wg0B-4ha6A:
undetectable
4wg0C-4ha6A:
undetectable
4wg0D-4ha6A:
undetectable		 4wg0B-4ha6A:
2.63
4wg0C-4ha6A:
2.63
4wg0D-4ha6A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 11 LEU A 483
ARG A 482
LEU A 489
LEU A 276
LEU A 265
 None
 1.07A 4wg0D-4ha6A:
undetectable
4wg0E-4ha6A:
undetectable
4wg0F-4ha6A:
undetectable		 4wg0D-4ha6A:
2.63
4wg0E-4ha6A:
2.63
4wg0F-4ha6A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 11 LEU A 483
ARG A 482
LEU A 489
LEU A 276
LEU A 265
 None
 1.11A 4wg0F-4ha6A:
undetectable
4wg0G-4ha6A:
undetectable
4wg0H-4ha6A:
undetectable		 4wg0F-4ha6A:
2.63
4wg0G-4ha6A:
2.63
4wg0H-4ha6A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 11 LEU A 265
LEU A 276
LEU A 483
ARG A 482
LEU A 489
 None
 1.11A 4wg0G-4ha6A:
undetectable
4wg0H-4ha6A:
undetectable
4wg0I-4ha6A:
undetectable		 4wg0G-4ha6A:
2.63
4wg0H-4ha6A:
2.63
4wg0I-4ha6A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 11 LEU A 265
LEU A 276
LEU A 483
ARG A 482
LEU A 489
 None
 1.11A 4wg0K-4ha6A:
undetectable
4wg0L-4ha6A:
undetectable
4wg0M-4ha6A:
undetectable		 4wg0K-4ha6A:
2.63
4wg0L-4ha6A:
2.63
4wg0M-4ha6A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 11 VAL A 491
LEU A 247
GLY A  24
SER A 272
LEU A 275
 None
None
FAD  A 601 (-3.2A)
None
FAD  A 601 ( 4.8A)
 1.27A 4zbqA-4ha6A:
2.5		 4zbqA-4ha6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		3 / 3 MET A 333
HIS A 460
GLY A 107
 None
PXM  A 609 (-3.8A)
FAD  A 601 (-3.4A)
 0.84A 5gwzB-4ha6A:
undetectable		 5gwzB-4ha6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		4 / 8 ARG A  35
GLU A 514
GLY A 155
PRO A 156
 None
 1.02A 5kgpB-4ha6A:
undetectable		 5kgpB-4ha6A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		3 / 3 HIS A 143
ASP A 148
HIS A 151
 None
 0.89A 5n1tW-4ha6A:
undetectable		 5n1tW-4ha6A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		4 / 8 ILE A  20
ALA A 260
LEU A 489
ILE A  22
 None
 0.81A 5uihA-4ha6A:
undetectable		 5uihA-4ha6A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 10 ARG A 110
HIS A 112
THR A 515
ILE A 140
ALA A 507
 None
 1.37A 5vyhA-4ha6A:
undetectable		 5vyhA-4ha6A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 9 ALA A 176
GLU A 175
ARG A 184
GLY A 352
LEU A 374
 None
 1.45A 5wgqA-4ha6A:
undetectable		 5wgqA-4ha6A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		5 / 10 GLY A 425
LEU A 430
VAL A 322
ALA A 318
LEU A 169
 None
 0.99A 6czmA-4ha6A:
undetectable
6czmC-4ha6A:
undetectable		 6czmA-4ha6A:
22.08
6czmC-4ha6A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ha6 PYRIDOXINE 4-OXIDASE
(Mesorhizobium
loti) 		4 / 8 GLN A 328
ILE A 174
ALA A 334
VAL A 351
 PXM  A 609 ( 3.9A)
None
None
None
 1.05A 6hu9a-4ha6A:
undetectable
6hu9e-4ha6A:
undetectable		 6hu9a-4ha6A:
23.57
6hu9e-4ha6A:
14.14