SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hac'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 12 LEU A 242
ALA A 246
ALA A 251
THR A 269
VAL A 164
 None
 1.26A 1cbrA-4hacA:
undetectable		 1cbrA-4hacA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 12 LEU A 242
ALA A 246
ALA A 251
THR A 269
VAL A 164
 None
 1.26A 1cbrB-4hacA:
undetectable		 1cbrB-4hacA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 12 ILE A  10
THR A 257
ALA A 259
GLY A  93
GLY A  89
 None
 1.07A 1rjdA-4hacA:
undetectable		 1rjdA-4hacA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 12 ILE A  10
THR A 257
ALA A 259
GLY A  93
GLY A  89
 None
 1.07A 1rjdB-4hacA:
undetectable		 1rjdB-4hacA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 12 ILE A  10
THR A 257
ALA A 259
GLY A  93
GLY A  89
 None
 1.07A 1rjdC-4hacA:
undetectable		 1rjdC-4hacA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		4 / 6 LEU A 239
GLY A 263
SER A  90
ILE A 165
 None
 0.82A 1yajF-4hacA:
undetectable		 1yajF-4hacA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 10 THR A 291
THR A 257
LEU A  31
LEU A  92
GLY A   8
 None
 1.25A 3lxiA-4hacA:
undetectable		 3lxiA-4hacA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 11 THR A 291
THR A 257
LEU A  31
LEU A  92
GLY A   8
 None
 1.25A 3lxiB-4hacA:
undetectable		 3lxiB-4hacA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 11 PRO A 136
ILE A 150
VAL A 141
PHE A 144
VAL A 148
 None
 1.33A 3rf4A-4hacA:
undetectable
3rf4C-4hacA:
undetectable		 3rf4A-4hacA:
17.24
3rf4C-4hacA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 11 PRO A 136
ILE A 150
VAL A 141
PHE A 144
VAL A 148
 None
 1.36A 3rf4A-4hacA:
undetectable
3rf4B-4hacA:
undetectable		 3rf4A-4hacA:
17.24
3rf4B-4hacA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 11 PRO A 136
ILE A 150
VAL A 141
PHE A 144
VAL A 148
 None
 1.31A 3rf4B-4hacA:
undetectable
3rf4C-4hacA:
undetectable		 3rf4B-4hacA:
17.24
3rf4C-4hacA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 9 THR A 291
THR A 257
LEU A  31
LEU A  92
GLY A   8
 None
 1.31A 4c9kA-4hacA:
undetectable		 4c9kA-4hacA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 10 THR A 291
THR A 257
LEU A  31
LEU A  92
GLY A   8
 None
 1.29A 4c9nB-4hacA:
undetectable		 4c9nB-4hacA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 9 THR A 291
THR A 257
LEU A  31
LEU A  92
GLY A   8
 None
 1.27A 4c9pA-4hacA:
undetectable		 4c9pA-4hacA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 10 THR A 291
THR A 257
LEU A  31
LEU A  92
GLY A   8
 None
 1.23A 4c9pB-4hacA:
undetectable		 4c9pB-4hacA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 12 ILE A 119
ALA A 120
ALA A  96
GLY A  93
THR A  99
 None
 0.91A 4enhA-4hacA:
undetectable		 4enhA-4hacA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 10 SER A 142
THR A  33
SER A   5
ASP A  83
TYR A  61
 None
 1.31A 4qb9A-4hacA:
undetectable		 4qb9A-4hacA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 12 SER A 142
THR A  33
SER A   5
ASP A  83
TYR A  61
 None
 1.26A 4qb9E-4hacA:
undetectable		 4qb9E-4hacA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		3 / 3 ASN A 235
SER A 240
ARG A 247
 None
 0.96A 5b2qA-4hacA:
1.8		 5b2qA-4hacA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 12 ILE A 100
GLY A 123
HIS A 124
GLN A 117
ALA A   6
 None
 1.06A 5n0xB-4hacA:
undetectable		 5n0xB-4hacA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 12 GLY A  91
GLY A 263
GLY A  89
THR A 168
VAL A 281
 None
 0.95A 5njvC-4hacA:
undetectable		 5njvC-4hacA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 12 GLY A  91
GLY A 263
GLY A  89
THR A 168
VAL A 281
 None
 0.88A 5wz1B-4hacA:
undetectable		 5wz1B-4hacA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		5 / 12 GLY A  91
GLY A 263
GLY A  89
THR A 168
VAL A 281
 None
 0.85A 5wz2C-4hacA:
undetectable		 5wz2C-4hacA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		6 / 11 ALA A 280
ALA A 246
ALA A 249
GLY A 286
GLY A 285
ALA A 284
 None
 1.36A 6hwdK-4hacA:
undetectable
6hwdL-4hacA:
undetectable		 6hwdK-4hacA:
15.08
6hwdL-4hacA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4hac MEVALONATE KINASE
(Methanosarcina
mazei) 		6 / 11 ALA A 280
ALA A 246
ALA A 249
GLY A 286
GLY A 285
ALA A 284
 None
 1.36A 6hwdY-4hacA:
undetectable
6hwdZ-4hacA:
undetectable		 6hwdY-4hacA:
15.08
6hwdZ-4hacA:
14.24