SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4had'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4had PROBABLE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		4 / 7 SER A 306
GLU A 120
GLU A  94
GLU A 285
 None
 1.17A 1knyA-4hadA:
undetectable
1knyB-4hadA:
undetectable		 1knyA-4hadA:
20.70
1knyB-4hadA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4had PROBABLE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		4 / 9 PHE A 289
ALA A 290
VAL A 293
GLU A 294
 None
 0.38A 2vufA-4hadA:
undetectable		 2vufA-4hadA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 4had PROBABLE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		5 / 11 LEU A  60
LYS A  89
VAL A  91
TYR A  56
TRP A  80
 None
 1.49A 3m8pA-4hadA:
undetectable
3m8pB-4hadA:
undetectable		 3m8pA-4hadA:
22.01
3m8pB-4hadA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 4had PROBABLE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		3 / 3 GLU A 200
TYR A 210
SER A 211
 None
 0.90A 4at0A-4hadA:
undetectable		 4at0A-4hadA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 4had PROBABLE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		3 / 3 GLU A 200
TYR A 210
SER A 212
 None
 0.88A 4at0A-4hadA:
undetectable		 4at0A-4hadA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4had PROBABLE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		5 / 12 THR A 184
LEU A 222
GLY A 150
VAL A 247
ILE A 245
 None
 0.99A 4c9lA-4hadA:
undetectable		 4c9lA-4hadA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4had PROBABLE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		5 / 12 THR A 184
LEU A 222
GLY A 150
VAL A 247
ILE A 245
 None
 0.98A 4c9lB-4hadA:
undetectable		 4c9lB-4hadA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 4had PROBABLE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		5 / 12 THR A 184
LEU A 222
GLY A 150
VAL A 247
ILE A 245
 None
 1.03A 4c9oA-4hadA:
undetectable		 4c9oA-4hadA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 4had PROBABLE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		5 / 12 THR A 184
LEU A 222
GLY A 150
VAL A 247
ILE A 245
 None
 1.02A 4c9oB-4hadA:
undetectable		 4c9oB-4hadA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4had PROBABLE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		3 / 3 ILE A  21
MET A  43
ARG A  46
 None
 0.94A 4lnwA-4hadA:
undetectable		 4lnwA-4hadA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4had PROBABLE
OXIDOREDUCTASE
PROTEIN
(Rhizobium
etli) 		3 / 3 ILE A  21
MET A  43
ARG A  46
 None
 0.93A 4lnxA-4hadA:
undetectable		 4lnxA-4hadA:
22.89