SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hao'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Yersinia
pestis) 		4 / 7 PHE A 100
TYR A 277
LEU A 281
THR A 185
 None
 1.19A 1rmtB-4haoA:
3.8		 1rmtB-4haoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Yersinia
pestis) 		5 / 12 ILE A  10
GLY A   9
GLY A  61
VAL A  37
ALA A  36
 None
 1.04A 1vptA-4haoA:
undetectable		 1vptA-4haoA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Yersinia
pestis) 		4 / 5 GLY A  12
HIS A  28
ASP A  51
ASP A  46
 None
 1.04A 2oxtB-4haoA:
undetectable		 2oxtB-4haoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Yersinia
pestis) 		5 / 10 ILE A 252
SER A 176
ILE A 160
PHE A 233
THR A 131
 None
 1.13A 2w9sC-4haoA:
undetectable		 2w9sC-4haoA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Yersinia
pestis) 		3 / 3 SER A 173
HIS A 158
ASP A 239
 None
 0.81A 2wa2B-4haoA:
3.5		 2wa2B-4haoA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Yersinia
pestis) 		4 / 8 ASP A 115
GLN A 112
PRO A 272
GLU A 118
 None
 1.11A 3oyaA-4haoA:
undetectable		 3oyaA-4haoA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Yersinia
pestis) 		5 / 11 ILE A 146
ASN A 268
ILE A  88
LEU A 267
THR A 144
 None
 1.16A 3qg2B-4haoA:
undetectable		 3qg2B-4haoA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Yersinia
pestis) 		4 / 5 SER A 123
PRO A 272
TYR A 275
VAL A 116
 None
 1.40A 3sufC-4haoA:
undetectable		 3sufC-4haoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Yersinia
pestis) 		5 / 12 ILE A 206
ILE A 229
VAL A 164
LEU A 231
ILE A 242
 None
 1.10A 3w67D-4haoA:
undetectable		 3w67D-4haoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Yersinia
pestis) 		5 / 12 ILE A 223
ALA A 205
LEU A 129
SER A 191
ILE A 180
 None
 1.30A 4gh8B-4haoA:
undetectable		 4gh8B-4haoA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Yersinia
pestis) 		4 / 4 ASN A  97
GLY A  96
ASP A 115
ASP A 107
 None
 1.30A 4n49A-4haoA:
undetectable		 4n49A-4haoA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Yersinia
pestis) 		4 / 6 ASP A 264
THR A 183
PRO A 184
THR A 185
 None
 1.08A 4yoaA-4haoA:
undetectable		 4yoaA-4haoA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Yersinia
pestis) 		3 / 3 VAL A 116
ARG A  95
PRO A 106
 None
None
ACY  A 402 (-4.9A)
 0.81A 5koxA-4haoA:
undetectable		 5koxA-4haoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Yersinia
pestis) 		4 / 6 VAL A  39
PRO A  14
ALA A  52
THR A  50
 None
 1.03A 6cduB-4haoA:
undetectable
6cduC-4haoA:
undetectable		 6cduB-4haoA:
22.47
6cduC-4haoA:
22.47