SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4hav RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 ARG B  90
ALA B  91
ASP B 129
GLY B 107
 None
 1.12A 1e7bA-4havB:
undetectable		 1e7bA-4havB:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4hav RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 ARG B  90
ALA B  91
ASP B 129
GLY B 107
 None
 1.23A 1e7cA-4havB:
undetectable		 1e7cA-4havB:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4hav RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE B 174
MET B 126
ARG B 123
ILE B 124
GLY B 107
 None
 1.29A 2lbdA-4havB:
undetectable		 2lbdA-4havB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 4hav RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 CYH B 160
PHE B 172
PHE B 174
 None
 0.84A 3cr5X-4havB:
undetectable		 3cr5X-4havB:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4hav RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 LYS B  98
ASP B  99
ARG B  95
 None
 0.91A 5jwaA-4havB:
undetectable
5jwaH-4havB:
undetectable		 5jwaA-4havB:
13.59
5jwaH-4havB:
13.59