SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hb5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4hb5 ENGINEERED PROTEIN
(synthetic
construct) 		4 / 6 ALA A  11
GLU A  10
ILE A   9
LEU A  23
 None
 0.95A 1xvaA-4hb5A:
undetectable
1xvaB-4hb5A:
undetectable		 1xvaA-4hb5A:
22.11
1xvaB-4hb5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4hb5 ENGINEERED PROTEIN
(synthetic
construct) 		5 / 12 VAL A  20
LEU A   8
LEU A  41
ILE A  52
ALA A  61
 None
 1.02A 4p65B-4hb5A:
undetectable
4p65D-4hb5A:
undetectable
4p65I-4hb5A:
undetectable
4p65J-4hb5A:
undetectable		 4p65B-4hb5A:
11.11
4p65D-4hb5A:
11.11
4p65I-4hb5A:
7.94
4p65J-4hb5A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 4hb5 ENGINEERED PROTEIN
(synthetic
construct) 		5 / 12 LEU A 107
VAL A  86
LEU A  74
ILE A 118
ALA A 127
 None
 1.05A 4p65F-4hb5A:
undetectable
4p65H-4hb5A:
undetectable
4p65K-4hb5A:
undetectable
4p65L-4hb5A:
undetectable		 4p65F-4hb5A:
11.11
4p65H-4hb5A:
11.11
4p65K-4hb5A:
7.94
4p65L-4hb5A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4hb5 ENGINEERED PROTEIN
(synthetic
construct) 		5 / 10 LEU A  74
LEU A  90
SER A  91
HIS A  82
VAL A  86
 None
 1.16A 5twjB-4hb5A:
undetectable		 5twjB-4hb5A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4hb5 ENGINEERED PROTEIN
(synthetic
construct) 		4 / 4 ASP A  69
SER A  68
ASP A  67
HIS A  42
 None
 1.32A 5wyqB-4hb5A:
undetectable		 5wyqB-4hb5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4hb5 ENGINEERED PROTEIN
(synthetic
construct) 		4 / 4 ASP A 102
SER A 101
ASP A 100
HIS A  75
 None
 1.33A 5wyqB-4hb5A:
undetectable		 5wyqB-4hb5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4hb5 ENGINEERED PROTEIN
(synthetic
construct) 		4 / 4 ASP A 135
SER A 134
ASP A 133
HIS A 108
 None
 1.32A 5wyqB-4hb5A:
undetectable		 5wyqB-4hb5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 4hb5 ENGINEERED PROTEIN
(synthetic
construct) 		4 / 7 LEU A  24
LEU A   8
ALA A  11
ALA A  12
 None
 0.88A 6a7jA-4hb5A:
undetectable		 6a7jA-4hb5A:
22.64