SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hb9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		4 / 8 LEU A 304
LEU A 172
TYR A 171
SER A 309
 None
EDO  A 502 ( 4.0A)
EDO  A 509 (-4.0A)
None
 1.16A 1hk2A-4hb9A:
undetectable		 1hk2A-4hb9A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		5 / 9 GLY A  11
ASP A 336
GLY A 159
ILE A   6
VAL A  26
 FAD  A 501 (-3.5A)
None
None
FAD  A 501 (-4.5A)
None
 1.02A 1hxwA-4hb9A:
undetectable		 1hxwA-4hb9A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		4 / 6 TYR A 171
HIS A 136
GLU A 362
VAL A 156
 EDO  A 509 (-4.0A)
None
None
None
 1.39A 1q13A-4hb9A:
undetectable		 1q13A-4hb9A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		3 / 3 ALA A 250
VAL A 248
TRP A 218
 None
None
EDO  A 505 ( 3.8A)
 0.61A 1tkqB-4hb9A:
undetectable		 1tkqB-4hb9A:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		3 / 3 TYR A  80
ARG A 204
GLN A 201
 None
 1.00A 1tw4A-4hb9A:
undetectable		 1tw4A-4hb9A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		3 / 3 VAL A 347
GLU A 353
GLU A 352
 None
 0.59A 2nv4A-4hb9A:
undetectable		 2nv4A-4hb9A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		4 / 7 GLY A   9
ALA A 333
VAL A 158
ILE A  28
 FAD  A 501 (-3.2A)
FAD  A 501 (-3.5A)
None
None
 0.79A 3a2qA-4hb9A:
undetectable		 3a2qA-4hb9A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		4 / 7 LEU A  86
VAL A 285
ILE A 221
ARG A 273
 None
 1.31A 3ik3A-4hb9A:
undetectable		 3ik3A-4hb9A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		5 / 12 ALA A 160
LEU A 340
LEU A 315
ILE A 319
ILE A   5
 None
 0.92A 3lbdA-4hb9A:
undetectable		 3lbdA-4hb9A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		3 / 3 HIS A 320
SER A 300
ASN A 370
 None
 0.75A 3s8pB-4hb9A:
undetectable		 3s8pB-4hb9A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		4 / 7 ASP A 161
GLY A  12
THR A  13
ILE A  28
 None
 0.87A 4acaC-4hb9A:
2.1		 4acaC-4hb9A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		5 / 12 GLY A  12
GLY A   9
THR A  13
LEU A 121
VAL A  26
 None
FAD  A 501 (-3.2A)
None
None
None
 1.04A 4f84A-4hb9A:
2.9		 4f84A-4hb9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		4 / 8 VAL A 347
GLN A 364
ILE A 358
MET A   1
 None
 1.11A 4iilA-4hb9A:
5.3		 4iilA-4hb9A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		4 / 4 TYR A  42
THR A 326
VAL A 244
ILE A  44
 FAD  A 501 (-3.5A)
None
None
FAD  A 501 (-4.4A)
 1.17A 4jx1F-4hb9A:
undetectable		 4jx1F-4hb9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		5 / 12 LEU A 117
LEU A  54
ILE A 108
ALA A  69
ILE A  46
 None
 0.91A 4o2bD-4hb9A:
undetectable		 4o2bD-4hb9A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		5 / 12 LEU A 334
LEU A 315
ALA A 337
THR A 124
ALA A 160
 None
 1.07A 4x1kA-4hb9A:
3.2
4x1kB-4hb9A:
undetectable		 4x1kA-4hb9A:
21.21
4x1kB-4hb9A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		3 / 3 HIS A 320
SER A 300
ASN A 370
 None
 0.75A 5cprB-4hb9A:
undetectable		 5cprB-4hb9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		4 / 7 GLY A  12
GLY A 159
TYR A  29
ALA A   8
 None
None
None
EDO  A 511 (-4.1A)
 0.96A 5e26A-4hb9A:
undetectable
5e26B-4hb9A:
undetectable		 5e26A-4hb9A:
21.67
5e26B-4hb9A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		5 / 12 ASP A 268
ALA A 265
PRO A 255
PHE A 261
TYR A 247
 None
 1.36A 5hfjH-4hb9A:
undetectable		 5hfjH-4hb9A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		5 / 10 SER A  36
ALA A 237
VAL A 232
GLU A 233
GLU A 115
 None
 1.21A 5i3cB-4hb9A:
undetectable		 5i3cB-4hb9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		5 / 11 SER A  36
ALA A 237
VAL A 232
GLU A 233
GLU A 115
 None
 1.19A 5i3cC-4hb9A:
undetectable		 5i3cC-4hb9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		5 / 12 LEU A 334
LEU A 315
ALA A 337
THR A 124
ALA A 160
 None
 1.08A 5nm5B-4hb9A:
undetectable		 5nm5B-4hb9A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		5 / 10 ALA A 160
GLY A   4
THR A  27
ILE A   5
ALA A   8
 None
None
None
None
EDO  A 511 (-4.1A)
 1.36A 5vyhA-4hb9A:
undetectable		 5vyhA-4hb9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		5 / 12 LEU A 117
LEU A  54
ILE A 108
ALA A  69
ILE A  46
 None
 0.88A 5xiwB-4hb9A:
undetectable		 5xiwB-4hb9A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		5 / 10 ILE A   5
ILE A  44
ALA A 330
LEU A 334
ALA A  53
 None
FAD  A 501 (-4.4A)
FAD  A 501 (-3.3A)
None
None
 1.41A 5zjiB-4hb9A:
undetectable		 5zjiB-4hb9A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		4 / 5 ARG A 366
ALA A 367
TYR A 368
GLN A 363
 None
 1.17A 6f6sA-4hb9A:
undetectable
6f6sB-4hb9A:
undetectable		 6f6sA-4hb9A:
12.27
6f6sB-4hb9A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE
(Photorhabdus
laumondii) 		4 / 7 GLY A 329
HIS A 320
VAL A 373
SER A 163
 FAD  A 501 (-3.0A)
None
None
None
 1.00A 6hu9S-4hb9A:
undetectable
6hu9q-4hb9A:
undetectable		 6hu9S-4hb9A:
13.51
6hu9q-4hb9A:
16.25