SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hbk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 10 GLU A  94
GLU A  51
ALA A  52
LEU A 104
GLU A  93
 None
 1.29A 1a29A-4hbkA:
undetectable		 1a29A-4hbkA:
15.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IHI_A_IU5A326_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 10 VAL A  47
TYR A  48
TRP A  79
HIS A 110
LEU A 295
 None
 0.85A 1ihiA-4hbkA:
44.1		 1ihiA-4hbkA:
40.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 9 LEU A 210
VAL A 254
ILE A  15
TYR A  39
ILE A  37
 None
 1.06A 1q6iA-4hbkA:
undetectable		 1q6iA-4hbkA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 12 LEU A 244
GLY A  16
GLY A  38
ILE A  37
VAL A 270
 None
 0.85A 2ieoA-4hbkA:
undetectable		 2ieoA-4hbkA:
18.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2INE_A_PACA317_0
(ALDOSE REDUCTASE)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		4 / 5 VAL A  47
TYR A  48
HIS A 110
TRP A 111
 None
 0.36A 2ineA-4hbkA:
45.9		 2ineA-4hbkA:
48.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ISF_A_PACA317_0
(ALDOSE REDUCTASE)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		4 / 5 VAL A  47
TYR A  48
HIS A 110
TRP A 111
 None
 0.34A 2isfA-4hbkA:
45.7		 2isfA-4hbkA:
48.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		3 / 3 ARG A 164
GLU A 308
SER A 199
 None
 0.90A 2xctD-4hbkA:
undetectable		 2xctD-4hbkA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 12 ILE A 253
PRO A 209
ALA A 208
PRO A 256
TYR A  48
 None
 1.09A 3jayA-4hbkA:
undetectable		 3jayA-4hbkA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 10 LEU A 210
VAL A 254
ILE A  15
TYR A  39
ILE A  37
 None
 1.06A 3kz7A-4hbkA:
undetectable		 3kz7A-4hbkA:
15.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 12 TYR A  48
TRP A  79
HIS A 110
ASN A 160
TYR A 207
 None
 0.53A 3r43A-4hbkA:
42.6		 3r43A-4hbkA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		6 / 10 TYR A  48
HIS A 110
ASN A 160
TYR A 207
PHE A 293
PRO A 305
 None
 0.79A 3r58A-4hbkA:
41.7		 3r58A-4hbkA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		6 / 12 TYR A  48
TRP A  79
HIS A 110
ASN A 160
TYR A 207
PHE A 293
 None
 0.84A 3r6iA-4hbkA:
41.5		 3r6iA-4hbkA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 9 TYR A  48
ASN A 160
TYR A 207
PHE A 293
PRO A 305
 None
 0.83A 3r8gA-4hbkA:
41.5		 3r8gA-4hbkA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 9 TYR A  48
HIS A 110
ASN A 160
TYR A 207
PRO A 305
 None
 0.55A 3r8gA-4hbkA:
41.5		 3r8gA-4hbkA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 12 TYR A  48
ASN A 160
TYR A 207
PHE A 293
PRO A 305
 None
 0.85A 3r94A-4hbkA:
41.4		 3r94A-4hbkA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 12 TYR A  48
HIS A 110
ASN A 160
TYR A 207
PRO A 305
 None
 0.61A 3r94A-4hbkA:
41.4		 3r94A-4hbkA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RX3_A_SUZA317_1
(ALDOSE REDUCTASE)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		6 / 10 VAL A  47
TYR A  48
HIS A 110
TRP A 111
PHE A 122
LEU A 295
 None
 0.86A 3rx3A-4hbkA:
45.8		 3rx3A-4hbkA:
51.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		4 / 7 TYR A  48
HIS A 110
TRP A 111
PHE A 122
 None
 0.78A 3s3gA-4hbkA:
45.8		 3s3gA-4hbkA:
51.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U2C_A_SUZA2001_1
(ALDOSE REDUCTASE)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 9 VAL A  47
TYR A  48
HIS A 110
TRP A 111
PHE A 122
 None
 0.62A 3u2cA-4hbkA:
46.1		 3u2cA-4hbkA:
46.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		6 / 12 TYR A  48
TRP A  79
HIS A 110
ASN A 160
TYR A 207
PRO A 305
 None
 0.59A 3ug8A-4hbkA:
41.5		 3ug8A-4hbkA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		4 / 7 TYR A  48
ASN A 160
GLU A 183
PRO A 305
 None
 0.64A 3ugrA-4hbkA:
41.7		 3ugrA-4hbkA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 8 VAL A  47
TRP A  79
HIS A 110
TRP A 111
PHE A 122
 None
 0.63A 3v35A-4hbkA:
45.8		 3v35A-4hbkA:
51.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 10 LEU A 244
GLY A  16
GLY A  38
ILE A  37
VAL A 270
 None
 0.97A 4dqbB-4hbkA:
undetectable		 4dqbB-4hbkA:
19.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 8 VAL A  47
TYR A  48
TRP A  79
HIS A 110
LEU A 295
 None
 0.90A 4jq1B-4hbkA:
43.7		 4jq1B-4hbkA:
40.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ4_A_IMNA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 10 VAL A  47
TYR A  48
HIS A 110
TYR A 207
LEU A 295
 None
 0.66A 4jq4A-4hbkA:
43.7		 4jq4A-4hbkA:
40.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 10 TYR A  48
HIS A 110
ASN A 160
TYR A 207
LEU A 295
 None
 0.51A 4jq4B-4hbkA:
43.8		 4jq4B-4hbkA:
40.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQA_A_ID8A401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 9 VAL A  47
TYR A  48
TRP A  79
HIS A 110
LEU A 295
 None
 0.85A 4jqaA-4hbkA:
43.6		 4jqaA-4hbkA:
40.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQA_B_ID8B401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 9 VAL A  47
TYR A  48
TRP A  79
HIS A 110
LEU A 295
 None
 0.73A 4jqaB-4hbkA:
43.8		 4jqaB-4hbkA:
40.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 10 VAL A  47
TYR A  48
TRP A  79
HIS A 110
LEU A 295
 None
 0.85A 4jtqA-4hbkA:
43.7		 4jtqA-4hbkA:
40.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTQ_B_FLPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 9 VAL A  47
TYR A  48
TRP A  79
HIS A 110
LEU A 295
 None
 0.79A 4jtqB-4hbkA:
44.1		 4jtqB-4hbkA:
40.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 8 VAL A  47
TYR A  48
TRP A  79
HIS A 110
LEU A 295
 None
 0.81A 4jtrA-4hbkA:
43.7		 4jtrA-4hbkA:
40.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		4 / 6 VAL A  47
TYR A  48
TRP A  79
HIS A 110
 None
 0.46A 4jtrB-4hbkA:
43.9		 4jtrB-4hbkA:
40.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		4 / 7 PRO A 112
PHE A 161
TRP A 111
TYR A 207
 None
 1.38A 4v2yB-4hbkA:
undetectable		 4v2yB-4hbkA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		4 / 8 PRO A 112
PHE A 161
TRP A 111
TYR A 207
 None
 1.35A 4v2zB-4hbkA:
undetectable		 4v2zB-4hbkA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		4 / 8 PRO A 112
PHE A 161
TRP A 111
TYR A 207
 None
 1.33A 4v30B-4hbkA:
undetectable		 4v30B-4hbkA:
16.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 9 TYR A  48
HIS A 110
ASN A 160
TYR A 207
PHE A 293
 None
 0.75A 4yvvA-4hbkA:
43.4		 4yvvA-4hbkA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 9 TYR A  48
TRP A  79
HIS A 110
ASN A 160
TYR A 207
 None
 0.49A 4yvvA-4hbkA:
43.4		 4yvvA-4hbkA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 12 TYR A  48
TRP A  79
HIS A 110
LEU A 115
ASN A 160
 None
 0.47A 4yvxA-4hbkA:
43.0		 4yvxA-4hbkA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVX_B_GMRB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 12 TYR A  48
TRP A  79
HIS A 110
LEU A 115
ASN A 160
 None
 0.47A 4yvxB-4hbkA:
43.0		 4yvxB-4hbkA:
39.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		4 / 7 PRO A 112
PHE A 161
TRP A 111
TYR A 207
 None
 1.34A 5amjB-4hbkA:
undetectable		 5amjB-4hbkA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 11 LEU A 210
VAL A 254
ILE A  15
TYR A  39
ILE A  37
 None
 1.10A 5d75A-4hbkA:
undetectable		 5d75A-4hbkA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 11 VAL A 254
ILE A  15
TYR A  39
ILE A 264
ILE A  37
 None
 1.03A 5hw8G-4hbkA:
undetectable		 5hw8G-4hbkA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		4 / 4 ASN A 179
LEU A 108
SER A 155
LEU A 104
 None
 1.30A 5kb5A-4hbkA:
undetectable		 5kb5A-4hbkA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		5 / 12 LEU A  65
ALA A  61
LEU A  58
ARG A  40
TYR A  39
 None
 1.30A 5ljcA-4hbkA:
undetectable		 5ljcA-4hbkA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		4 / 4 LEU A 180
MET A   6
ILE A 109
LEU A 106
 None
 1.34A 5nfpA-4hbkA:
undetectable		 5nfpA-4hbkA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		3 / 3 GLU A 143
HIS A  87
VAL A  88
 None
 0.89A 5trqB-4hbkA:
undetectable		 5trqB-4hbkA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)
(Schistosoma
japonicum) 		4 / 6 TYR A 107
GLN A 181
GLU A  51
ALA A  91
 None
 1.23A 6djzB-4hbkA:
undetectable		 6djzB-4hbkA:
21.78