SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hbs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		3 / 3 ASN A 394
PHE A 417
VAL A  79
 None
 0.56A 1kijA-4hbsA:
undetectable		 1kijA-4hbsA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		4 / 4 ALA A 270
ARG A 268
GLN A 277
GLU A 279
 None
 1.43A 1lquB-4hbsA:
undetectable		 1lquB-4hbsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		5 / 11 SER A  92
PHE A  80
LEU A 175
VAL A 195
THR A 151
 None
 1.26A 1q23F-4hbsA:
undetectable		 1q23F-4hbsA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		5 / 12 VAL A 420
ILE A 391
ILE A 328
VAL A  55
LEU A 426
 None
 0.91A 1qhsA-4hbsA:
undetectable		 1qhsA-4hbsA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		5 / 12 VAL A 420
ILE A 391
ILE A 328
VAL A  55
LEU A 426
 None
 0.83A 1qhyA-4hbsA:
undetectable		 1qhyA-4hbsA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		4 / 5 TRP A  91
GLY A  76
GLY A  75
PHE A 417
 None
 1.04A 2qr2A-4hbsA:
undetectable
2qr2B-4hbsA:
undetectable		 2qr2A-4hbsA:
20.67
2qr2B-4hbsA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		4 / 6 TYR A 325
VAL A 318
TYR A 257
ASP A 249
 None
 1.29A 2x45A-4hbsA:
undetectable		 2x45A-4hbsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		4 / 7 LEU A 356
LEU A 389
SER A 392
THR A  81
 None
 0.82A 3lm8B-4hbsA:
undetectable
3lm8D-4hbsA:
undetectable		 3lm8B-4hbsA:
20.48
3lm8D-4hbsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		5 / 12 GLY A  99
GLY A  72
ASN A  74
VAL A 149
GLY A  75
 None
 0.89A 4dc3B-4hbsA:
undetectable		 4dc3B-4hbsA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		4 / 4 MET A 118
ASP A 126
LEU A  66
ARG A 414
 None
 1.40A 4kjlA-4hbsA:
0.0		 4kjlA-4hbsA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		4 / 7 ARG A 336
VAL A 374
GLN A 330
LEU A 359
 None
 1.02A 4zphA-4hbsA:
undetectable
4zphB-4hbsA:
undetectable		 4zphA-4hbsA:
22.72
4zphB-4hbsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		3 / 3 TYR A 257
THR A 259
THR A 245
 None
 0.80A 5aoxB-4hbsA:
undetectable		 5aoxB-4hbsA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		5 / 10 GLY A 275
THR A 269
TRP A 278
LEU A 191
LEU A 256
 None
 1.32A 5fhzC-4hbsA:
undetectable		 5fhzC-4hbsA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		3 / 3 VAL A 266
SER A 343
MET A 340
 None
 0.92A 5ikqA-4hbsA:
undetectable		 5ikqA-4hbsA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		5 / 12 ILE A 306
GLY A 348
HIS A 345
TYR A 242
ALA A 265
 None
 1.27A 5n0xB-4hbsA:
undetectable		 5n0xB-4hbsA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		4 / 5 ARG A 268
ALA A 267
TYR A 257
ILE A 306
 None
 1.32A 6f6sA-4hbsA:
undetectable
6f6sB-4hbsA:
undetectable		 6f6sA-4hbsA:
12.53
6f6sB-4hbsA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4hbs PUTATIVE HYDROLASE
(Bacteroides
ovatus) 		4 / 5 ARG A 268
ALA A 267
TYR A 257
ILE A 306
 None
 1.15A 6g9bA-4hbsA:
undetectable
6g9bB-4hbsA:
undetectable		 6g9bA-4hbsA:
12.53
6g9bB-4hbsA:
12.40