SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hbz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita)
5 / 12 GLY A 154
ILE A  98
LEU A  99
VAL A 102
LEU A 113
None
1.17A 1r30A-4hbzA:
undetectable
1r30A-4hbzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita)
5 / 12 GLY A 154
ILE A  98
LEU A  99
VAL A 102
LEU A 113
None
1.17A 1r30B-4hbzA:
undetectable
1r30B-4hbzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita)
5 / 12 LEU A 148
GLY A 145
GLY A 143
LEU A 175
LEU A 159
PGE  A 203 ( 4.8A)
None
None
None
None
0.94A 2nxeB-4hbzA:
2.8
2nxeB-4hbzA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita)
4 / 6 ARG A  36
TYR A  91
THR A  71
ALA A  69
None
1.26A 2ql8A-4hbzA:
undetectable
2ql8B-4hbzA:
undetectable
2ql8A-4hbzA:
18.72
2ql8B-4hbzA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita)
5 / 12 LEU A 148
GLY A 145
GLY A 143
LEU A 175
LEU A 159
PGE  A 203 ( 4.8A)
None
None
None
None
0.93A 2zbpA-4hbzA:
undetectable
2zbpA-4hbzA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita)
5 / 12 LEU A 148
GLY A 145
GLY A 143
LEU A 175
LEU A 159
PGE  A 203 ( 4.8A)
None
None
None
None
0.97A 3cjtG-4hbzA:
undetectable
3cjtG-4hbzA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita)
4 / 7 ILE A 121
GLY A  94
VAL A  64
LEU A 128
None
0.91A 3elzA-4hbzA:
undetectable
3elzA-4hbzA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita)
4 / 7 LEU A  38
ARG A  72
GLY A 116
MET A  22
None
1.01A 3hcrB-4hbzA:
undetectable
3hcrB-4hbzA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita)
5 / 12 ALA A 138
GLY A 145
GLY A 143
LEU A 148
VAL A 129
None
None
None
PGE  A 203 ( 4.8A)
None
1.03A 3o7wA-4hbzA:
undetectable
3o7wA-4hbzA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita)
4 / 4 TYR A  86
SER A  66
GLN A  73
THR A  74
None
1.30A 5n0tB-4hbzA:
3.9
5n0tB-4hbzA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita)
5 / 12 SER A  29
ALA A  26
TYR A  91
ALA A  27
GLY A  28
ACY  A 205 (-4.6A)
None
None
None
None
1.02A 5tzoB-4hbzA:
undetectable
5tzoB-4hbzA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita)
5 / 10 GLY A  50
LEU A  53
VAL A  63
ALA A  82
LEU A 113
None
1.16A 6czmA-4hbzA:
undetectable
6czmC-4hbzA:
undetectable
6czmA-4hbzA:
19.38
6czmC-4hbzA:
19.38