SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS6_A_DXCA75_0
(PPCA)		 4hc3 PPCA
(Geobacter
sulfurreducens) 		8 / 8 ILE A   4
LEU A   6
LYS A  33
LYS A  37
PHE A  41
MET A  45
LYS A  49
GLY A  50
 HEM  A  72 (-4.4A)
HEM  A  74 ( 3.7A)
DXC  A  75 ( 4.4A)
DXC  A  75 ( 2.6A)
DXC  A  75 ( 4.3A)
DXC  A  75 (-4.2A)
DXC  A  75 ( 4.1A)
DXC  A  75 ( 3.7A)
 0.39A 1os6A-4hc3A:
15.7		 1os6A-4hc3A:
98.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 4hc3 PPCA
(Geobacter
sulfurreducens) 		8 / 8 ILE A   4
LEU A   6
LYS A  33
LYS A  37
PHE A  41
MET A  45
LYS A  49
GLY A  50
 HEM  A  72 (-4.4A)
HEM  A  74 ( 3.7A)
DXC  A  75 ( 4.4A)
DXC  A  75 ( 2.6A)
DXC  A  75 ( 4.3A)
DXC  A  75 (-4.2A)
DXC  A  75 ( 4.1A)
DXC  A  75 ( 3.7A)
 0.39A 3selX-4hc3A:
15.5		 3selX-4hc3A:
97.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4hc3 PPCA
(Geobacter
sulfurreducens) 		7 / 7 ILE A   4
LYS A  33
LYS A  37
PHE A  41
MET A  45
LYS A  49
GLY A  50
 HEM  A  72 (-4.4A)
DXC  A  75 ( 4.4A)
DXC  A  75 ( 2.6A)
DXC  A  75 ( 4.3A)
DXC  A  75 (-4.2A)
DXC  A  75 ( 4.1A)
DXC  A  75 ( 3.7A)
 0.15A 3sj0X-4hc3A:
15.7		 3sj0X-4hc3A:
97.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 4hc3 PPCA
(Geobacter
sulfurreducens) 		6 / 6 ILE A   4
LEU A   6
LYS A  37
PHE A  41
MET A  45
GLY A  50
 HEM  A  72 (-4.4A)
HEM  A  74 ( 3.7A)
DXC  A  75 ( 2.6A)
DXC  A  75 ( 4.3A)
DXC  A  75 (-4.2A)
DXC  A  75 ( 3.7A)
 0.25A 3sj1X-4hc3A:
15.6		 3sj1X-4hc3A:
97.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4hc3 PPCA
(Geobacter
sulfurreducens) 		9 / 9 ILE A   4
LEU A   6
LYS A  33
LYS A  37
ILE A  38
PHE A  41
MET A  45
LYS A  49
GLY A  50
 HEM  A  72 (-4.4A)
HEM  A  74 ( 3.7A)
DXC  A  75 ( 4.4A)
DXC  A  75 ( 2.6A)
DXC  A  75 (-4.2A)
DXC  A  75 ( 4.3A)
DXC  A  75 (-4.2A)
DXC  A  75 ( 4.1A)
DXC  A  75 ( 3.7A)
 0.38A 3sj4X-4hc3A:
15.6		 3sj4X-4hc3A:
97.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4hc3 PPCA
(Geobacter
sulfurreducens) 		4 / 6 GLU A  56
LYS A  52
PRO A  62
GLU A  67
 None
SO4  A  77 (-4.7A)
HEM  A  73 ( 4.4A)
None
 1.40A 4a7tF-4hc3A:
undetectable		 4a7tF-4hc3A:
18.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HBF_A_DXCA75_0
(PPCA)		 4hc3 PPCA
(Geobacter
sulfurreducens) 		7 / 7 ILE A   4
LEU A   6
LYS A  37
PHE A  41
MET A  45
LYS A  49
GLY A  50
 HEM  A  72 (-4.4A)
HEM  A  74 ( 3.7A)
DXC  A  75 ( 2.6A)
DXC  A  75 ( 4.3A)
DXC  A  75 (-4.2A)
DXC  A  75 ( 4.1A)
DXC  A  75 ( 3.7A)
 0.20A 4hbfA-4hc3A:
undetectable		 4hbfA-4hc3A:
98.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HC3_A_DXCA75_0
(PPCA)		 4hc3 PPCA
(Geobacter
sulfurreducens) 		7 / 7 ILE A   4
LEU A   6
LYS A  37
PHE A  41
MET A  45
LYS A  49
GLY A  50
 HEM  A  72 (-4.4A)
HEM  A  74 ( 3.7A)
DXC  A  75 ( 2.6A)
DXC  A  75 ( 4.3A)
DXC  A  75 (-4.2A)
DXC  A  75 ( 4.1A)
DXC  A  75 ( 3.7A)
 0.22A 4hc3A-4hc3A:
16.3		 4hc3A-4hc3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HDL_A_DXCA75_0
(PPCA)		 4hc3 PPCA
(Geobacter
sulfurreducens) 		7 / 8 ILE A   4
LYS A  33
ILE A  38
PHE A  41
MET A  45
LYS A  49
GLY A  50
 HEM  A  72 (-4.4A)
DXC  A  75 ( 4.4A)
DXC  A  75 (-4.2A)
DXC  A  75 ( 4.3A)
DXC  A  75 (-4.2A)
DXC  A  75 ( 4.1A)
DXC  A  75 ( 3.7A)
 0.17A 4hdlA-4hc3A:
15.6		 4hdlA-4hc3A:
97.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_A_STIA302_1
(DEOXYCYTIDINE KINASE)		 4hc3 PPCA
(Geobacter
sulfurreducens) 		5 / 12 VAL A  24
PRO A  62
GLU A  67
CYH A  68
GLU A  57
 HEM  A  72 ( 4.1A)
HEM  A  73 ( 4.4A)
None
HEM  A  74 (-2.1A)
None
 1.40A 5mqtA-4hc3A:
undetectable		 5mqtA-4hc3A:
12.55