SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hc5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4hc5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Sphaerobacter
thermophilus) 		4 / 5 PHE A 125
VAL A  60
VAL A  18
ASP A 119
 None
 1.33A 1dz6B-4hc5A:
undetectable		 1dz6B-4hc5A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4hc5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Sphaerobacter
thermophilus) 		5 / 10 PHE A 125
VAL A  60
VAL A  51
VAL A  18
ASP A 119
 None
 1.48A 2qboA-4hc5A:
undetectable		 2qboA-4hc5A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4hc5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Sphaerobacter
thermophilus) 		4 / 6 LEU A 127
PHE A 125
PHE A 117
LEU A  94
 None
 0.95A 3abkP-4hc5A:
undetectable
3abkW-4hc5A:
undetectable		 3abkP-4hc5A:
19.38
3abkW-4hc5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4hc5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Sphaerobacter
thermophilus) 		4 / 7 HIS A  12
GLN A  59
VAL A  52
ALA A  56
 None
 1.04A 3kp6B-4hc5A:
undetectable		 3kp6B-4hc5A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hc5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Sphaerobacter
thermophilus) 		4 / 6 LEU A 127
PHE A 125
PHE A 117
LEU A  94
 None
 0.98A 3wg7P-4hc5A:
undetectable
3wg7W-4hc5A:
undetectable		 3wg7P-4hc5A:
19.38
3wg7W-4hc5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 4hc5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Sphaerobacter
thermophilus) 		4 / 5 ILE A  87
GLN A 112
ARG A 113
GLU A 130
 None
 1.29A 5fseC-4hc5A:
undetectable		 5fseC-4hc5A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4hc5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Sphaerobacter
thermophilus) 		4 / 5 LEU A 127
PHE A 125
PHE A 117
LEU A  94
 None
 0.92A 5x1bP-4hc5A:
undetectable		 5x1bP-4hc5A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4hc5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
(Sphaerobacter
thermophilus) 		4 / 5 PHE A 126
VAL A  99
PRO A 105
VAL A 128
 None
GOL  A 302 (-3.6A)
None
None
 1.19A 6ekzA-4hc5A:
undetectable		 6ekzA-4hc5A:
22.22