SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hc6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A   4
VAL A   6
TRP A  64
 None
 0.98A 1bdwA-4hc6A:
undetectable
1bdwB-4hc6A:
undetectable		 1bdwA-4hc6A:
8.73
1bdwB-4hc6A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 105
LEU A  75
GLY A   5
ALA A  63
SER A  67
 None
BR  A 211 ( 4.6A)
None
None
None
 1.12A 2aylA-4hc6A:
undetectable		 2aylA-4hc6A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 LYS A  57
ARG A  96
VAL A  95
 BR  A 213 (-3.4A)
None
None
 1.06A 2r2vC-4hc6A:
undetectable
2r2vD-4hc6A:
undetectable		 2r2vC-4hc6A:
12.50
2r2vD-4hc6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 SER A  40
ARG A  37
PRO A  33
GLY A  34
 None
None
CL  A 205 (-3.3A)
None
 1.13A 2y7kB-4hc6A:
undetectable		 2y7kB-4hc6A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 SER A  40
ARG A  37
PRO A  33
GLY A  34
 None
None
CL  A 205 (-3.3A)
None
 1.06A 2y7pA-4hc6A:
undetectable		 2y7pA-4hc6A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 125
LEU A 127
VAL A  95
ILE A 101
ILE A  83
 None
 1.25A 3jw3B-4hc6A:
undetectable		 3jw3B-4hc6A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 105
LEU A  75
GLY A   5
ALA A  63
SER A  67
 None
BR  A 211 ( 4.6A)
None
None
None
 1.03A 3kk6A-4hc6A:
1.4		 3kk6A-4hc6A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 105
LEU A  75
GLY A   5
ALA A  63
SER A  67
 None
BR  A 211 ( 4.6A)
None
None
None
 0.99A 3nt1A-4hc6A:
1.8		 3nt1A-4hc6A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 105
LEU A  75
GLY A   5
ALA A  63
SER A  67
 None
BR  A 211 ( 4.6A)
None
None
None
 0.99A 3nt1B-4hc6A:
undetectable		 3nt1B-4hc6A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 105
LEU A  75
GLY A   5
ALA A  63
SER A  67
 None
BR  A 211 ( 4.6A)
None
None
None
 1.04A 3rr3C-4hc6A:
undetectable		 3rr3C-4hc6A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 105
LEU A  75
GLY A   5
ALA A  63
SER A  67
 None
BR  A 211 ( 4.6A)
None
None
None
 1.04A 3rr3D-4hc6A:
undetectable		 3rr3D-4hc6A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A  61
ARG A  81
THR A  98
LEU A  97
 None
 1.02A 3wg7N-4hc6A:
undetectable
3wg7W-4hc6A:
undetectable		 3wg7N-4hc6A:
14.37
3wg7W-4hc6A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 THR A 120
ALA A 122
SER A 113
THR A 115
 None
None
CL  A 202 (-3.1A)
None
 0.78A 4ik7B-4hc6A:
undetectable		 4ik7B-4hc6A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 120
ALA A 122
SER A 113
THR A 115
 None
None
CL  A 202 (-3.1A)
None
 0.86A 4pwjB-4hc6A:
undetectable		 4pwjB-4hc6A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  61
ARG A  81
THR A  98
LEU A  97
 None
 0.91A 5zcpA-4hc6A:
undetectable
5zcpJ-4hc6A:
undetectable		 5zcpA-4hc6A:
14.37
5zcpJ-4hc6A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  61
ARG A  81
THR A  98
LEU A  97
 None
 0.91A 5zcqA-4hc6A:
undetectable
5zcqJ-4hc6A:
undetectable		 5zcqA-4hc6A:
14.37
5zcqJ-4hc6A:
15.15