SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hcj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4hcj THIJ/PFPI DOMAIN
PROTEIN
(Brachyspira
murdochii) 		4 / 7 VAL A 144
VAL A 169
LEU A 170
ALA A 102
 None
 0.74A 1pthA-4hcjA:
undetectable		 1pthA-4hcjA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4hcj THIJ/PFPI DOMAIN
PROTEIN
(Brachyspira
murdochii) 		4 / 7 VAL A 144
VAL A 169
LEU A 170
ALA A 102
 None
 0.73A 1pthB-4hcjA:
undetectable		 1pthB-4hcjA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4hcj THIJ/PFPI DOMAIN
PROTEIN
(Brachyspira
murdochii) 		4 / 4 GLY A 107
GLY A 103
THR A 152
LEU A 117
 None
 0.95A 3si7C-4hcjA:
undetectable
3si7D-4hcjA:
undetectable		 3si7C-4hcjA:
21.80
3si7D-4hcjA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 4hcj THIJ/PFPI DOMAIN
PROTEIN
(Brachyspira
murdochii) 		5 / 12 GLY A  74
GLY A 105
PHE A  72
MET A  11
GLU A  19
 None
 1.30A 3t7sA-4hcjA:
2.5		 3t7sA-4hcjA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4hcj THIJ/PFPI DOMAIN
PROTEIN
(Brachyspira
murdochii) 		5 / 12 ILE A  76
MET A  11
GLY A  74
SER A 106
VAL A  37
 None
None
None
None
FMT  A 205 (-4.5A)
 1.16A 3v8vA-4hcjA:
3.6		 3v8vA-4hcjA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4hcj THIJ/PFPI DOMAIN
PROTEIN
(Brachyspira
murdochii) 		4 / 5 ARG A  86
VAL A  62
LEU A  57
SER A  38
 CL  A 204 (-4.3A)
None
None
None
 1.23A 4e1gA-4hcjA:
undetectable		 4e1gA-4hcjA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4hcj THIJ/PFPI DOMAIN
PROTEIN
(Brachyspira
murdochii) 		5 / 7 ALA A 165
ALA A 102
GLY A 103
ILE A 150
ILE A 100
 None
 1.13A 4eatA-4hcjA:
undetectable		 4eatA-4hcjA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 4hcj THIJ/PFPI DOMAIN
PROTEIN
(Brachyspira
murdochii) 		5 / 9 ALA A 165
ALA A 102
GLY A 103
ILE A 150
ILE A 100
 None
 1.11A 4eatB-4hcjA:
2.2		 4eatB-4hcjA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 4hcj THIJ/PFPI DOMAIN
PROTEIN
(Brachyspira
murdochii) 		3 / 3 TRP A  82
GLN A  14
THR A  80
 None
 0.96A 4m2xA-4hcjA:
undetectable		 4m2xA-4hcjA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4hcj THIJ/PFPI DOMAIN
PROTEIN
(Brachyspira
murdochii) 		5 / 12 ASP A 128
SER A 106
LEU A 125
ILE A  76
GLY A  77
 None
 0.97A 4y8wC-4hcjA:
undetectable		 4y8wC-4hcjA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4hcj THIJ/PFPI DOMAIN
PROTEIN
(Brachyspira
murdochii) 		5 / 12 VAL A 169
ILE A 104
VAL A  73
VAL A 151
PHE A 162
 None
 1.35A 6ap6A-4hcjA:
2.7		 6ap6A-4hcjA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4hcj THIJ/PFPI DOMAIN
PROTEIN
(Brachyspira
murdochii) 		5 / 12 VAL A 169
ILE A 104
VAL A  73
VAL A 151
PHE A 162
 None
 1.35A 6ap6B-4hcjA:
3.3		 6ap6B-4hcjA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4hcj THIJ/PFPI DOMAIN
PROTEIN
(Brachyspira
murdochii) 		5 / 12 VAL A  73
GLY A 107
PHE A 162
GLU A  29
VAL A 166
 None
 1.10A 6bqgA-4hcjA:
undetectable		 6bqgA-4hcjA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 4hcj THIJ/PFPI DOMAIN
PROTEIN
(Brachyspira
murdochii) 		5 / 10 GLU A  20
GLY A  74
GLY A  75
ILE A 104
GLY A 155
 None
 0.54A 6e5zA-4hcjA:
26.6		 6e5zA-4hcjA:
26.02