SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hcr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 4hcr PF-547659 HEAVY
CHAIN
(Homo
sapiens) 		4 / 4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.96A 1lqtB-4hcrH:
undetectable		 1lqtB-4hcrH:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 4hcr PF-547659 HEAVY
CHAIN
(Homo
sapiens) 		4 / 4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.99A 1lquB-4hcrH:
undetectable		 1lquB-4hcrH:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4hcr PF-547659 HEAVY
CHAIN
(Homo
sapiens) 		4 / 7 SER H 104
ASP H 106
SER H 102
SER H 103
 None
 1.10A 2cmlA-4hcrH:
undetectable		 2cmlA-4hcrH:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4hcr PF-547659 HEAVY
CHAIN
(Homo
sapiens) 		4 / 8 SER H 104
ASP H 106
SER H 102
SER H 103
 None
 1.12A 2cmlB-4hcrH:
undetectable		 2cmlB-4hcrH:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 4hcr PF-547659 HEAVY
CHAIN
(Homo
sapiens) 		4 / 8 SER H 104
ASP H 106
SER H 102
SER H 103
 None
 1.08A 2cmlC-4hcrH:
undetectable		 2cmlC-4hcrH:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 4hcr PF-547659 HEAVY
CHAIN
(Homo
sapiens) 		4 / 8 SER H 104
ASP H 106
SER H 102
SER H 103
 None
 1.16A 2cmlD-4hcrH:
undetectable		 2cmlD-4hcrH:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 4hcr PF-547659 HEAVY
CHAIN
(Homo
sapiens) 		4 / 6 ASN H 215
SER H 214
HIS H 211
ASP H 210
 None
 1.19A 3aruA-4hcrH:
4.8		 3aruA-4hcrH:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4hcr PF-547659 HEAVY
CHAIN
(Homo
sapiens) 		5 / 10 PHE H 133
GLY H 129
THR H 216
VAL H 209
VAL H 218
 None
 1.19A 4jx1B-4hcrH:
undetectable		 4jx1B-4hcrH:
18.34