SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hd1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4hd1 SQUALENE SYNTHASE
HPNC
(Alicyclobacillus
acidocaldarius) 		3 / 3 GLU A  72
TYR A  69
PHE A  86
 None
 0.89A 1eqbB-4hd1A:
undetectable		 1eqbB-4hd1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4hd1 SQUALENE SYNTHASE
HPNC
(Alicyclobacillus
acidocaldarius) 		3 / 3 GLU A  72
TYR A  69
PHE A  86
 None
 0.88A 1eqbA-4hd1A:
undetectable		 1eqbA-4hd1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4hd1 SQUALENE SYNTHASE
HPNC
(Alicyclobacillus
acidocaldarius) 		3 / 3 GLU A  72
TYR A  69
PHE A  86
 None
 0.89A 1eqbD-4hd1A:
undetectable		 1eqbD-4hd1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4hd1 SQUALENE SYNTHASE
HPNC
(Alicyclobacillus
acidocaldarius) 		3 / 3 GLU A  72
TYR A  69
PHE A  86
 None
 0.89A 1eqbC-4hd1A:
undetectable		 1eqbC-4hd1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4hd1 SQUALENE SYNTHASE
HPNC
(Alicyclobacillus
acidocaldarius) 		4 / 6 LEU A 139
VAL A 140
ILE A 143
TYR A  69
 None
 0.48A 1s9qA-4hd1A:
undetectable		 1s9qA-4hd1A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4hd1 SQUALENE SYNTHASE
HPNC
(Alicyclobacillus
acidocaldarius) 		5 / 12 PHE A 144
GLN A 238
TYR A 242
VAL A  29
CYH A 159
 None
 1.14A 2aouA-4hd1A:
0.0		 2aouA-4hd1A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_A_AZZA1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4hd1 SQUALENE SYNTHASE
HPNC
(Alicyclobacillus
acidocaldarius) 		5 / 10 GLU A 213
VAL A 182
VAL A 164
ARG A 216
ALA A 217
 None
 1.43A 2jj8A-4hd1A:
0.0		 2jj8A-4hd1A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4hd1 SQUALENE SYNTHASE
HPNC
(Alicyclobacillus
acidocaldarius) 		5 / 12 ALA A  46
ILE A  93
LEU A  98
PHE A 103
TYR A  69
 None
 1.15A 2qk8A-4hd1A:
undetectable		 2qk8A-4hd1A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4hd1 SQUALENE SYNTHASE
HPNC
(Alicyclobacillus
acidocaldarius) 		5 / 12 ALA A  46
ILE A  93
LEU A  98
PHE A 103
TYR A  69
 None
 1.19A 3datA-4hd1A:
undetectable		 3datA-4hd1A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4hd1 SQUALENE SYNTHASE
HPNC
(Alicyclobacillus
acidocaldarius) 		5 / 9 ALA A  46
ILE A  93
LEU A  98
PHE A 103
TYR A  69
 None
 1.13A 3fl9D-4hd1A:
undetectable		 3fl9D-4hd1A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4hd1 SQUALENE SYNTHASE
HPNC
(Alicyclobacillus
acidocaldarius) 		5 / 9 LEU A 125
LEU A 194
ARG A 184
THR A 118
ILE A 180
 None
 1.12A 4ubsA-4hd1A:
undetectable		 4ubsA-4hd1A:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 4hd1 SQUALENE SYNTHASE
HPNC
(Alicyclobacillus
acidocaldarius) 		4 / 7 VAL A 214
ALA A 165
GLY A 246
ARG A 254
 None
 0.89A 5fpdA-4hd1A:
2.4		 5fpdA-4hd1A:
21.41