SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hdi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 4hdi IG HEAVY CHAIN V
REGION RF, IG
GAMMA-3 CHAIN C
REGION
(Mus
musculus) 		5 / 10 LEU H  86
LEU H 116
SER H  21
LEU H  20
LEU H  18
 None
 1.15A 2xn7A-4hdiH:
undetectable
2xn7B-4hdiH:
undetectable		 2xn7A-4hdiH:
22.16
2xn7B-4hdiH:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 4hdi IG HEAVY CHAIN V
REGION RF, IG
GAMMA-3 CHAIN C
REGION
(Mus
musculus) 		4 / 7 TRP H 195
VAL H 143
SER H 192
THR H 138
 None
 1.20A 3arrA-4hdiH:
6.4		 3arrA-4hdiH:
15.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4hdi IG HEAVY CHAIN V
REGION RF, IG
GAMMA-3 CHAIN C
REGION
(Mus
musculus) 		3 / 3 TYR H  60
GLY H  66
THR H  69
 None
 0.16A 6cjkB-4hdiH:
24.6		 6cjkB-4hdiH:
56.70