SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hdj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 260
GLY A 262
ALA A 205
LEU A 195
 None
 0.78A 1e7bB-4hdjA:
undetectable		 1e7bB-4hdjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 111
GLY A 101
LEU A  60
GLU A  75
 None
 0.88A 1fduD-4hdjA:
undetectable		 1fduD-4hdjA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 147
GLY A 160
PRO A 187
ILE A 189
 None
 0.79A 1n49A-4hdjA:
undetectable		 1n49A-4hdjA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 160
ILE A 159
PRO A 187
ALA A 196
 None
 0.78A 1n49A-4hdjA:
undetectable		 1n49A-4hdjA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 147
GLY A 160
PRO A 187
ILE A 189
 None
 0.94A 1n49D-4hdjA:
undetectable		 1n49D-4hdjA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 246
GLU A 278
ASP A 296
GLY A 299
ALA A 255
 None
 1.19A 1nw3A-4hdjA:
undetectable		 1nw3A-4hdjA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 207
GLY A 160
ILE A 159
PRO A 187
ALA A 196
 None
 0.70A 1rl8A-4hdjA:
undetectable		 1rl8A-4hdjA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 10 ASP A 207
GLY A 160
ILE A 159
PRO A 187
ALA A 196
 None
 0.86A 1sh9B-4hdjA:
undetectable		 1sh9B-4hdjA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 207
GLY A 160
ILE A 159
PRO A 187
ALA A 196
 None
 0.72A 2b7zA-4hdjA:
undetectable		 2b7zA-4hdjA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 207
GLY A 160
ILE A 159
PRO A 187
ALA A 196
 None
 0.69A 2b7zB-4hdjA:
undetectable		 2b7zB-4hdjA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 188
GLY A 237
ARG A 357
SER A 271
ALA A 254
 None
 1.14A 2br4C-4hdjA:
undetectable		 2br4C-4hdjA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 188
LEU A 245
GLY A 237
ASP A 235
ALA A 316
 None
 1.16A 2br4D-4hdjA:
undetectable		 2br4D-4hdjA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 194
GLY A 160
ILE A 159
PRO A 142
 None
 0.88A 2fxdB-4hdjA:
undetectable		 2fxdB-4hdjA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 207
GLY A 160
ILE A 159
PRO A 187
ALA A 196
 None
 0.72A 2nmyB-4hdjA:
undetectable		 2nmyB-4hdjA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 207
GLY A 160
ILE A 159
PRO A 187
ALA A 196
 None
 0.71A 2rkfA-4hdjA:
undetectable		 2rkfA-4hdjA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 12 SER A  99
GLY A 100
GLY A 116
GLU A 137
ILE A 159
 None
 0.96A 2wa2B-4hdjA:
undetectable		 2wa2B-4hdjA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		6 / 11 SER A 271
SER A 272
GLN A 217
LEU A 264
LEU A 257
SER A 249
 None
 1.37A 2xn5A-4hdjA:
undetectable		 2xn5A-4hdjA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 161
VAL A 151
THR A 153
ASP A 117
 None
 1.07A 2zaxA-4hdjA:
undetectable		 2zaxA-4hdjA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 10 ASP A 207
GLY A 160
ILE A 159
PRO A 187
ALA A 196
 None
 0.86A 3ekpB-4hdjA:
undetectable		 3ekpB-4hdjA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 10 ASP A 207
GLY A 160
ILE A 159
PRO A 187
ALA A 196
 None
 0.82A 3ekpC-4hdjA:
undetectable		 3ekpC-4hdjA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 9 ASP A 207
GLY A 160
ILE A 159
PRO A 187
ALA A 196
 None
 0.80A 3ektB-4hdjA:
undetectable		 3ektB-4hdjA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 161
VAL A 151
THR A 153
ASP A 117
 None
 1.06A 3fwgB-4hdjA:
undetectable		 3fwgB-4hdjA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 160
ILE A 159
PRO A 187
ALA A 196
VAL A 204
 None
 0.96A 3t3cB-4hdjA:
undetectable		 3t3cB-4hdjA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 328
VAL A 354
GLY A 353
TYR A 332
 None
 1.19A 3w9tA-4hdjA:
undetectable		 3w9tA-4hdjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 328
VAL A 354
GLY A 353
TYR A 332
 None
 1.19A 3w9tB-4hdjA:
undetectable		 3w9tB-4hdjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 328
VAL A 354
GLY A 353
TYR A 332
 None
 1.19A 3w9tC-4hdjA:
undetectable		 3w9tC-4hdjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 328
VAL A 354
GLY A 353
TYR A 332
 None
 1.18A 3w9tD-4hdjA:
undetectable		 3w9tD-4hdjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 328
VAL A 354
GLY A 353
TYR A 332
 None
 1.19A 3w9tE-4hdjA:
undetectable		 3w9tE-4hdjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 328
VAL A 354
GLY A 353
TYR A 332
 None
 1.19A 3w9tF-4hdjA:
undetectable		 3w9tF-4hdjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 328
VAL A 354
GLY A 353
TYR A 332
 None
 1.19A 3w9tG-4hdjA:
undetectable		 3w9tG-4hdjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 353
ASP A 328
GLY A 331
VAL A 367
HIS A 334
 None
 1.21A 4c5lB-4hdjA:
undetectable		 4c5lB-4hdjA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 353
ASP A 328
GLY A 331
VAL A 367
HIS A 334
 None
 1.16A 4c5lC-4hdjA:
undetectable		 4c5lC-4hdjA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 4 ASN A 145
GLY A 146
ASP A 117
ASP A 162
 None
 1.40A 4n49A-4hdjA:
undetectable		 4n49A-4hdjA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  32
VAL A 326
VAL A 344
TYR A 332
 None
 1.12A 4r7iA-4hdjA:
undetectable		 4r7iA-4hdjA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 4 GLU A 330
GLY A 331
HIS A 334
ARG A 312
 None
 0.75A 4r82A-4hdjA:
undetectable
4r82B-4hdjA:
undetectable		 4r82A-4hdjA:
21.74
4r82B-4hdjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 359
ALA A  63
ILE A  81
LEU A 374
 None
 1.02A 5te8A-4hdjA:
undetectable		 5te8A-4hdjA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 220
GLY A 236
ASP A 235
VAL A 203
ASP A 156
 None
 1.41A 6clxB-4hdjA:
undetectable		 6clxB-4hdjA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 161
VAL A 151
THR A 153
ASP A 117
 None
 1.00A 6cp4A-4hdjA:
undetectable		 6cp4A-4hdjA:
23.31