SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hdo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4hdo KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE A 530
LEU A 626
ALA A 535
GLU A 534
 None
 1.09A 1xvaA-4hdoA:
undetectable
1xvaB-4hdoA:
undetectable		 1xvaA-4hdoA:
21.16
1xvaB-4hdoA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4hdo KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		3 / 3 GLY A 439
GLU A 420
ASN A 441
 None
 0.62A 1zq9A-4hdoA:
undetectable		 1zq9A-4hdoA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hdo KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 713
ASP A 498
ASN A 496
 None
 0.81A 2bm9A-4hdoA:
undetectable		 2bm9A-4hdoA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4hdo KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 621
GLN A 622
PHE A 625
LEU A 608
 None
 0.86A 2einP-4hdoA:
undetectable
2einW-4hdoA:
undetectable		 2einP-4hdoA:
20.67
2einW-4hdoA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4hdo KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 621
GLN A 622
PHE A 625
LEU A 608
 None
 0.98A 2zxwP-4hdoA:
undetectable
2zxwW-4hdoA:
undetectable		 2zxwP-4hdoA:
20.67
2zxwW-4hdoA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4hdo KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 621
GLN A 622
PHE A 625
LEU A 608
 None
 0.97A 3ag1C-4hdoA:
undetectable
3ag1J-4hdoA:
undetectable		 3ag1C-4hdoA:
20.67
3ag1J-4hdoA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4hdo KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A 621
GLN A 622
PHE A 625
LEU A 608
 None
 0.94A 3ag2P-4hdoA:
undetectable
3ag2W-4hdoA:
undetectable		 3ag2P-4hdoA:
20.67
3ag2W-4hdoA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4hdo KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A 621
GLN A 622
PHE A 625
LEU A 608
 None
 0.95A 3ag4P-4hdoA:
undetectable
3ag4W-4hdoA:
undetectable		 3ag4P-4hdoA:
20.67
3ag4W-4hdoA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 4hdo KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 514
THR A 457
ARG A 509
ARG A 536
 None
 1.34A 6ew0B-4hdoA:
undetectable		 6ew0B-4hdoA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 4hdo KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 514
THR A 457
ARG A 509
ARG A 536
 None
 1.34A 6ew0D-4hdoA:
undetectable		 6ew0D-4hdoA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 4hdo KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 514
THR A 457
ARG A 509
ARG A 536
 None
 1.35A 6ew0H-4hdoA:
undetectable		 6ew0H-4hdoA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 4hdo KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 514
THR A 457
ARG A 509
ARG A 536
 None
 1.34A 6ew0I-4hdoA:
undetectable		 6ew0I-4hdoA:
13.25