SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hds'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4hds ARSA
ARSB
(Sporomusa
ovata) 		5 / 12 SER B 312
VAL B 313
LEU B 295
PHE B  37
GLU A 312
 EDO  B 902 (-2.8A)
None
None
None
None
 1.33A 1a27A-4hdsB:
undetectable		 1a27A-4hdsB:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACJ_A_THAA999_1
(ACETYLCHOLINESTERASE)		 4hds ARSA
(Sporomusa
ovata) 		5 / 9 GLY A 116
GLU A 244
ILE A 179
HIS A  69
GLY A 178
 None
 1.40A 1acjA-4hdsA:
3.2		 1acjA-4hdsA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4hds ARSA
(Sporomusa
ovata) 		6 / 11 ILE A 188
ALA A 301
PHE A 192
SER A 283
PRO A 281
ILE A 275
 None
 1.47A 1dg5A-4hdsA:
undetectable		 1dg5A-4hdsA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4hds ARSA
ARSB
(Sporomusa
ovata) 		5 / 9 VAL A 332
LEU A  39
ALA B 308
SER B 312
LEU B 309
 None
None
None
EDO  B 902 (-2.8A)
None
 1.18A 1eqgA-4hdsA:
undetectable		 1eqgA-4hdsA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4hds ARSA
(Sporomusa
ovata) 		5 / 10 GLY A 294
ALA A 309
THR A 270
SER A 290
ALA A 289
 None
 1.32A 1gtnO-4hdsA:
undetectable
1gtnP-4hdsA:
undetectable		 1gtnO-4hdsA:
12.75
1gtnP-4hdsA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4hds ARSA
(Sporomusa
ovata) 		5 / 9 GLY A 294
ALA A 309
THR A 270
SER A 290
ALA A 289
 None
 1.30A 1gtnQ-4hdsA:
undetectable
1gtnR-4hdsA:
undetectable		 1gtnQ-4hdsA:
12.75
1gtnR-4hdsA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 4hds ARSB
(Sporomusa
ovata) 		5 / 9 GLY B 242
VAL B 267
ILE B 236
GLY B 234
ILE B   9
 None
 0.96A 1hpvA-4hdsB:
undetectable		 1hpvA-4hdsB:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4hds ARSA
(Sporomusa
ovata) 		5 / 10 SER A 185
ILE A 188
GLY A 241
GLY A 178
GLU A 244
 None
 1.07A 1mehA-4hdsA:
undetectable		 1mehA-4hdsA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 4hds ARSB
(Sporomusa
ovata) 		6 / 12 GLY B 170
VAL B 235
LEU B 232
LEU B 169
ILE B 106
LEU B 105
 None
 1.10A 1mx1D-4hdsB:
undetectable		 1mx1D-4hdsB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4hds ARSA
(Sporomusa
ovata) 		5 / 9 LEU A 174
ALA A  65
GLY A 157
ALA A 247
LEU A 237
 None
 1.12A 1nr6A-4hdsA:
undetectable		 1nr6A-4hdsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4hds ARSA
(Sporomusa
ovata) 		5 / 11 THR A 182
GLU A 244
MET A 177
GLU A 176
ILE A  81
 None
None
IPH  A 801 (-3.2A)
None
None
 1.39A 1odiE-4hdsA:
undetectable		 1odiE-4hdsA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4hds ARSB
(Sporomusa
ovata) 		5 / 12 ILE B 167
ALA B  98
GLY B 170
GLY B 304
LEU B 232
 None
 1.01A 1rjdB-4hdsB:
undetectable		 1rjdB-4hdsB:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4hds ARSB
(Sporomusa
ovata) 		5 / 12 ILE B 167
ALA B  98
GLY B 170
GLY B 304
LEU B 232
 None
 1.02A 1rjdC-4hdsB:
undetectable		 1rjdC-4hdsB:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 4hds ARSB
(Sporomusa
ovata) 		5 / 12 LEU B   5
ILE B 155
GLY B 152
VAL B 108
VAL B 151
 None
 1.07A 1vptA-4hdsB:
undetectable		 1vptA-4hdsB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4hds ARSB
(Sporomusa
ovata) 		5 / 12 ALA B 244
GLY B 234
ILE B 167
LEU B 263
ILE B 149
 None
 1.13A 1x1aA-4hdsB:
undetectable		 1x1aA-4hdsB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4hds ARSB
(Sporomusa
ovata) 		5 / 12 GLY B 170
GLY B 304
LEU B 251
THR B 253
ALA B 252
 None
 0.99A 2egvA-4hdsB:
undetectable		 2egvA-4hdsB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4hds ARSB
(Sporomusa
ovata) 		5 / 12 GLY B 170
GLY B 304
LEU B 251
THR B 253
ALA B 252
 None
 0.97A 2egvB-4hdsB:
undetectable		 2egvB-4hdsB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4hds ARSB
(Sporomusa
ovata) 		5 / 12 GLN B 157
LEU B   2
ILE B   9
VAL B 267
ALA B 156
 None
 1.31A 2g72B-4hdsB:
undetectable		 2g72B-4hdsB:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 4hds ARSA
(Sporomusa
ovata) 		4 / 7 TYR A  79
TYR A  91
GLU A 176
GLY A 318
 IPH  A 801 ( 4.0A)
None
None
None
 1.16A 2ha4B-4hdsA:
2.9		 2ha4B-4hdsA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 4hds ARSA
(Sporomusa
ovata) 		5 / 9 GLY A 142
THR A 140
ALA A 222
LEU A 223
THR A 187
 None
 1.00A 2npnA-4hdsA:
undetectable		 2npnA-4hdsA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 4hds ARSA
(Sporomusa
ovata) 		5 / 12 ILE A 160
ALA A  65
ILE A 275
ILE A 279
LEU A 174
 None
 0.97A 2rlcA-4hdsA:
undetectable		 2rlcA-4hdsA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4hds ARSB
(Sporomusa
ovata) 		5 / 6 LEU B 127
GLU B 150
ALA B 145
LEU B 227
THR B 222
 None
 1.36A 2roxB-4hdsB:
undetectable		 2roxB-4hdsB:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 4hds ARSB
(Sporomusa
ovata) 		4 / 8 ALA B 128
SER B 131
GLY B 226
ALA B  65
 None
 0.88A 2vh3B-4hdsB:
undetectable		 2vh3B-4hdsB:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4hds ARSA
(Sporomusa
ovata) 		4 / 8 MET A 110
VAL A 112
TYR A 123
ASN A 100
 None
 1.25A 2wekB-4hdsA:
undetectable		 2wekB-4hdsA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4hds ARSA
ARSB
(Sporomusa
ovata;
Sporomusa
ovata) 		4 / 6 LEU A  36
ARG B  83
PRO B  93
VAL B 291
 None
 1.17A 2ygoA-4hdsA:
undetectable		 2ygoA-4hdsA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 4hds ARSA
(Sporomusa
ovata) 		5 / 12 ALA A  67
ILE A 132
ASP A  68
ILE A 179
ALA A  72
 None
 1.26A 3axtA-4hdsA:
undetectable		 3axtA-4hdsA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 4hds ARSA
(Sporomusa
ovata) 		4 / 8 HIS A 291
ASP A 265
PHE A 102
GLY A 318
 None
 0.87A 3c0zB-4hdsA:
2.4		 3c0zB-4hdsA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 4hds ARSB
(Sporomusa
ovata) 		5 / 12 LEU B 258
ALA B 256
LEU B 248
LEU B 251
LEU B 271
 None
 1.02A 3erdA-4hdsB:
undetectable		 3erdA-4hdsB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hds ARSA
ARSB
(Sporomusa
ovata) 		5 / 12 LEU B 297
ASP A 328
LEU A 313
LEU A 311
GLY A 322
 None
EDO  B 902 (-3.7A)
None
None
None
 1.37A 3g1uC-4hdsB:
3.1		 3g1uC-4hdsB:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hds ARSA
ARSB
(Sporomusa
ovata) 		5 / 12 LEU B 297
ASP A 328
LEU A 313
LEU A 311
GLY A 322
 None
EDO  B 902 (-3.7A)
None
None
None
 1.32A 3glqA-4hdsB:
3.0		 3glqA-4hdsB:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hds ARSA
ARSB
(Sporomusa
ovata) 		5 / 12 LEU B 297
ASP A 328
LEU A 313
LEU A 311
GLY A 322
 None
EDO  B 902 (-3.7A)
None
None
None
 1.32A 3glqB-4hdsB:
2.8		 3glqB-4hdsB:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 4hds ARSB
(Sporomusa
ovata) 		4 / 5 LYS B  43
VAL B 267
ILE B  47
MET B 311
 None
 1.48A 3gvuA-4hdsB:
undetectable		 3gvuA-4hdsB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 4hds ARSB
(Sporomusa
ovata) 		5 / 12 LEU B 258
ALA B 256
LEU B 248
LEU B 251
LEU B 271
 None
 1.04A 3hm1A-4hdsB:
undetectable		 3hm1A-4hdsB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4hds ARSA
(Sporomusa
ovata) 		5 / 12 GLY A 116
ALA A 118
THR A  84
ILE A 132
GLN A 149
 None
 1.16A 3id6C-4hdsA:
undetectable		 3id6C-4hdsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4hds ARSB
(Sporomusa
ovata) 		5 / 12 ILE B 149
GLY B 234
ALA B 257
ALA B 239
ILE B 229
 None
 1.06A 3jayA-4hdsB:
undetectable		 3jayA-4hdsB:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 4hds ARSA
ARSB
(Sporomusa
ovata) 		4 / 8 GLY B 304
MET A 329
PHE A 105
GLY B 310
 None
None
EDO  B 902 (-4.6A)
None
 0.96A 3ko0O-4hdsB:
undetectable
3ko0Q-4hdsB:
undetectable		 3ko0O-4hdsB:
13.26
3ko0Q-4hdsB:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4hds ARSB
(Sporomusa
ovata) 		4 / 8 THR B 205
LEU B 202
ALA B 200
ARG B 198
 None
None
EDO  B 901 ( 4.0A)
None
 0.96A 3kp6A-4hdsB:
undetectable		 3kp6A-4hdsB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4hds ARSB
(Sporomusa
ovata) 		5 / 9 LEU B  34
VAL B  24
ILE B  40
ALA B  41
ALA B 316
 None
 1.09A 3mdvA-4hdsB:
undetectable		 3mdvA-4hdsB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hds ARSA
ARSB
(Sporomusa
ovata) 		5 / 12 LEU B 297
ASP A 328
LEU A 313
LEU A 311
GLY A 322
 None
EDO  B 902 (-3.7A)
None
None
None
 1.36A 3n58A-4hdsB:
2.7		 3n58A-4hdsB:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4hds ARSA
ARSB
(Sporomusa
ovata) 		5 / 12 HIS A  86
PHE B 327
GLY A  96
ALA A  97
SER A  98
 None
 1.24A 3n8xA-4hdsA:
undetectable		 3n8xA-4hdsA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4hds ARSB
(Sporomusa
ovata) 		3 / 3 VAL B 101
VAL B 247
SER B 274
 EDO  B 902 ( 4.4A)
None
None
 0.71A 3n8xB-4hdsB:
undetectable		 3n8xB-4hdsB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4hds ARSA
(Sporomusa
ovata) 		5 / 12 GLU A 244
GLY A 175
GLU A 176
ALA A  99
VAL A  64
 None
 1.14A 3nvkF-4hdsA:
undetectable
3nvkJ-4hdsA:
undetectable		 3nvkF-4hdsA:
23.81
3nvkJ-4hdsA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4hds ARSA
ARSB
(Sporomusa
ovata) 		5 / 12 ILE B  94
PHE B  97
ALA B 308
ALA B 277
GLY A  37
 None
 1.04A 3nxuA-4hdsB:
undetectable		 3nxuA-4hdsB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4hds ARSB
(Sporomusa
ovata) 		5 / 12 ILE B 183
ALA B 252
LEU B 192
ILE B  62
GLY B 173
 None
None
EDO  B 901 (-4.5A)
None
None
 1.04A 3ozwB-4hdsB:
2.6		 3ozwB-4hdsB:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4hds ARSB
(Sporomusa
ovata) 		4 / 5 LYS B  43
VAL B 267
ILE B  47
MET B 311
 None
 1.49A 3pyyB-4hdsB:
undetectable		 3pyyB-4hdsB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4hds ARSA
(Sporomusa
ovata) 		5 / 10 ILE A 188
ALA A 301
PHE A 192
SER A 283
ILE A 275
 None
 1.30A 3qgtA-4hdsA:
undetectable		 3qgtA-4hdsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4hds ARSA
(Sporomusa
ovata) 		5 / 10 ILE A 188
ALA A 301
PHE A 192
SER A 283
ILE A 275
 None
 1.25A 3qgtB-4hdsA:
undetectable		 3qgtB-4hdsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 4hds ARSB
(Sporomusa
ovata) 		5 / 10 ALA B 239
ILE B  61
GLY B 152
ILE B 149
VAL B 246
 None
 1.01A 3t3cB-4hdsB:
undetectable		 3t3cB-4hdsB:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 4hds ARSB
(Sporomusa
ovata) 		6 / 11 GLY B 175
ALA B 178
VAL B 224
GLY B 225
GLY B 226
THR B 255
 None
 1.46A 3ufnA-4hdsB:
undetectable		 3ufnA-4hdsB:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4hds ARSA
(Sporomusa
ovata) 		5 / 12 GLY A 250
GLY A 254
ILE A 160
VAL A 161
ALA A 276
 None
 1.02A 4a6dA-4hdsA:
undetectable		 4a6dA-4hdsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4hds ARSA
(Sporomusa
ovata) 		5 / 12 GLY A 250
GLY A 254
ILE A 160
VAL A 161
ALA A 276
 None
 1.02A 4a6eA-4hdsA:
undetectable		 4a6eA-4hdsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4hds ARSA
(Sporomusa
ovata) 		5 / 12 GLY A  70
ALA A  72
VAL A  75
ALA A 144
ASP A  68
 None
 1.19A 4df3A-4hdsA:
undetectable		 4df3A-4hdsA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4hds ARSA
(Sporomusa
ovata) 		5 / 12 GLY A  70
ALA A  72
VAL A  75
ALA A 144
ASP A  68
 None
 1.14A 4df3B-4hdsA:
undetectable		 4df3B-4hdsA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4hds ARSA
(Sporomusa
ovata) 		4 / 7 ALA A 222
ALA A 191
GLY A 190
ILE A 188
 None
 0.65A 4eatA-4hdsA:
undetectable		 4eatA-4hdsA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4hds ARSA
(Sporomusa
ovata) 		6 / 10 ILE A 188
LEU A 305
PHE A 192
SER A 283
PRO A 281
ILE A 275
 None
 1.42A 4g8zX-4hdsA:
undetectable		 4g8zX-4hdsA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4hds ARSA
(Sporomusa
ovata) 		4 / 5 GLY A 266
ASP A 265
GLU A 244
VAL A 113
 None
 0.84A 4nkvD-4hdsA:
undetectable		 4nkvD-4hdsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4hds ARSB
(Sporomusa
ovata) 		5 / 12 GLU B 171
ILE B  62
ILE B 259
GLY B 226
ILE B 229
 None
 1.16A 4o1eA-4hdsB:
undetectable		 4o1eA-4hdsB:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4hds ARSB
(Sporomusa
ovata) 		5 / 12 MET B  63
ASN B  67
ALA B 179
GLY B 176
LEU B 177
 None
 1.48A 4oadA-4hdsB:
undetectable		 4oadA-4hdsB:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4hds ARSA
(Sporomusa
ovata) 		5 / 12 GLY A 241
ASN A 226
GLY A 233
SER A 185
PHE A 192
 None
 1.29A 4obwC-4hdsA:
undetectable		 4obwC-4hdsA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4hds ARSA
(Sporomusa
ovata) 		5 / 12 HIS A 298
GLY A 294
ASP A 265
HIS A 291
GLY A 318
 None
 0.95A 4qa0A-4hdsA:
undetectable		 4qa0A-4hdsA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4hds ARSA
(Sporomusa
ovata) 		5 / 12 HIS A 298
GLY A 294
ASP A 265
HIS A 291
GLY A 318
 None
 0.91A 4qa2A-4hdsA:
undetectable		 4qa2A-4hdsA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4hds ARSA
(Sporomusa
ovata) 		5 / 12 HIS A 298
GLY A 294
ASP A 265
HIS A 291
GLY A 318
 None
 0.93A 4qa2B-4hdsA:
undetectable		 4qa2B-4hdsA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4hds ARSA
(Sporomusa
ovata) 		5 / 12 GLY A 320
GLY A 322
MET A 325
SER A  98
ALA A  99
 None
 1.06A 4qtuD-4hdsA:
undetectable		 4qtuD-4hdsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4hds ARSB
(Sporomusa
ovata) 		5 / 9 ALA B 228
ALA B  65
ILE B 149
GLY B 152
ALA B 148
 None
 1.13A 4qvqK-4hdsB:
undetectable
4qvqL-4hdsB:
undetectable		 4qvqK-4hdsB:
21.15
4qvqL-4hdsB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4hds ARSB
(Sporomusa
ovata) 		5 / 12 ALA B 260
GLN B 157
ALA B   8
ILE B   9
ILE B 160
 None
 0.98A 4r3aA-4hdsB:
undetectable		 4r3aA-4hdsB:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4hds ARSB
(Sporomusa
ovata) 		5 / 11 ALA B  45
LEU B  44
LEU B  56
ASN B 322
LEU B 318
 None
 1.16A 4wg0I-4hdsB:
undetectable
4wg0J-4hdsB:
undetectable
4wg0K-4hdsB:
undetectable		 4wg0I-4hdsB:
2.59
4wg0J-4hdsB:
2.59
4wg0K-4hdsB:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4hds ARSB
(Sporomusa
ovata) 		5 / 11 ALA B  45
LEU B  44
LEU B  56
ASN B 322
LEU B 318
 None
 1.15A 4wg0K-4hdsB:
undetectable
4wg0L-4hdsB:
undetectable
4wg0M-4hdsB:
undetectable		 4wg0K-4hdsB:
2.59
4wg0L-4hdsB:
2.59
4wg0M-4hdsB:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4hds ARSB
(Sporomusa
ovata) 		4 / 4 ILE B  61
GLY B 231
ILE B 155
LEU B 232
 None
 0.85A 5dzkl-4hdsB:
2.4
5dzkz-4hdsB:
undetectable		 5dzkl-4hdsB:
21.64
5dzkz-4hdsB:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4hds ARSB
(Sporomusa
ovata) 		5 / 9 SER B 131
GLY B 225
ALA B 206
VAL B 224
ILE B 183
 None
 1.19A 5i3cA-4hdsB:
undetectable		 5i3cA-4hdsB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4hds ARSB
(Sporomusa
ovata) 		5 / 11 SER B 131
GLY B 225
ALA B 206
VAL B 224
ILE B 183
 None
 1.15A 5i3cC-4hdsB:
undetectable		 5i3cC-4hdsB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 4hds ARSB
(Sporomusa
ovata) 		5 / 12 LEU B 251
ALA B 252
GLU B 199
ALA B 206
ALA B 182
 None
 1.15A 5n5dB-4hdsB:
undetectable		 5n5dB-4hdsB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 4hds ARSA
(Sporomusa
ovata) 		5 / 12 GLY A 233
GLY A 250
GLY A 246
VAL A 161
ILE A 158
 None
 0.92A 5njvC-4hdsA:
undetectable		 5njvC-4hdsA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 4hds ARSB
(Sporomusa
ovata) 		3 / 3 VAL B 203
LYS B 223
MET B 140
 None
 0.78A 5nknA-4hdsB:
undetectable		 5nknA-4hdsB:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4hds ARSB
(Sporomusa
ovata) 		5 / 9 LEU B 177
GLY B 175
GLY B 173
LEU B 251
ALA B 180
 None
 1.00A 5o96A-4hdsB:
2.4
5o96B-4hdsB:
2.8		 5o96A-4hdsB:
19.59
5o96B-4hdsB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4hds ARSB
(Sporomusa
ovata) 		5 / 11 LEU B 177
GLY B 175
GLY B 173
LEU B 251
ALA B 180
 None
 0.99A 5o96G-4hdsB:
3.2		 5o96G-4hdsB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4hds ARSB
(Sporomusa
ovata) 		6 / 10 GLY B 170
GLY B 304
LEU B 177
LEU B 251
THR B 253
ALA B 252
 None
 1.45A 5o96G-4hdsB:
3.2
5o96H-4hdsB:
2.1		 5o96G-4hdsB:
19.59
5o96H-4hdsB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4hds ARSB
(Sporomusa
ovata) 		5 / 10 LEU B 177
GLY B 175
GLY B 173
LEU B 251
ALA B 180
 None
 0.90A 5o96G-4hdsB:
3.2
5o96H-4hdsB:
2.1		 5o96G-4hdsB:
19.59
5o96H-4hdsB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4hds ARSA
(Sporomusa
ovata) 		4 / 4 VAL A  64
VAL A 112
TYR A  91
GLN A  95
 None
 1.01A 5qggA-4hdsA:
undetectable		 5qggA-4hdsA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4hds ARSA
(Sporomusa
ovata) 		4 / 4 VAL A  64
VAL A 112
TYR A  91
GLN A  95
 None
 0.96A 5qgoA-4hdsA:
undetectable		 5qgoA-4hdsA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4hds ARSA
(Sporomusa
ovata) 		4 / 4 VAL A  64
VAL A 112
TYR A  91
GLN A  95
 None
 0.97A 5qgpA-4hdsA:
undetectable		 5qgpA-4hdsA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4hds ARSA
(Sporomusa
ovata) 		4 / 4 VAL A  64
VAL A 112
TYR A  91
GLN A  95
 None
 1.03A 5qgqA-4hdsA:
undetectable		 5qgqA-4hdsA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4hds ARSA
(Sporomusa
ovata) 		4 / 4 VAL A  64
VAL A 112
TYR A  91
GLN A  95
 None
 1.01A 5qhbA-4hdsA:
undetectable		 5qhbA-4hdsA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4hds ARSB
(Sporomusa
ovata) 		5 / 10 GLY B 170
GLY B 304
LEU B 251
THR B 253
ALA B 252
 None
 1.08A 5vm8B-4hdsB:
undetectable		 5vm8B-4hdsB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 4hds ARSA
(Sporomusa
ovata) 		4 / 7 SER A 184
GLY A 246
ALA A 249
VAL A 262
 None
 0.78A 6dwnB-4hdsA:
undetectable		 6dwnB-4hdsA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4hds ARSA
(Sporomusa
ovata) 		4 / 6 MET A 115
GLY A 242
ALA A 249
LEU A 248
 None
 1.00A 6fosA-4hdsA:
undetectable		 6fosA-4hdsA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4hds ARSA
ARSB
(Sporomusa
ovata;
Sporomusa
ovata) 		5 / 11 HIS A 291
GLY A 322
SER A 324
PHE B  37
ALA B 316
 None
 1.16A 6ieyA-4hdsA:
4.9
6ieyB-4hdsA:
3.4		 6ieyA-4hdsA:
22.16
6ieyB-4hdsA:
22.16