SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4hdt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	11GS_A_EAAA211_1 (GLUTATHIONE S-TRANSFERASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 7	TYR A 92 VAL A 148 ILE A 73 GLY A 116	None	0.82A	11gsA-4hdtA: undetectable	11gsA-4hdtA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DZ4_A_CAMA502_0 (CYTOCHROME P450-CAM)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 6	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.07A	1dz4A-4hdtA: undetectable	1dz4A-4hdtA: 20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DZ4_B_CAMB502_0 (CYTOCHROME P450-CAM)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 6	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.07A	1dz4B-4hdtA: undetectable	1dz4B-4hdtA: 20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GM7_B_PNNB1577_0 (PENICILLIN G ACYLASE ALPHA SUBUNIT PENICILLIN G ACYLASE BETA SUBUNIT)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 8	SER A 29 SER A 76 ALA A 72 ILE A 73	None None ACT A 406 (-3.6A) None	1.07A	1gm7A-4hdtA: undetectable 1gm7B-4hdtA: undetectable	1gm7A-4hdtA: 22.25 1gm7B-4hdtA: 23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KGL_A_RTLA175_0 (CELLULAR RETINOL-BINDING PROTEIN TYPE I)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	5 / 12	LEU A 282 TYR A 105 GLY A 99 ILE A 98 LEU A 64	None	1.21A	1kglA-4hdtA: undetectable	1kglA-4hdtA: 16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T87_A_CAMA1422_0 (CYTOCHROME P450-CAM)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 7	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.03A	1t87A-4hdtA: undetectable	1t87A-4hdtA: 19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T88_B_CAMB2422_0 (CYTOCHROME P450-CAM)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 5	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.07A	1t88B-4hdtA: undetectable	1t88B-4hdtA: 19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X70_B_715B801_2 (DIPEPTIDYL PEPTIDASE IV)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	3 / 3	PHE A 144 TYR A 92 TYR A 290	None	0.96A	1x70B-4hdtA: undetectable	1x70B-4hdtA: 18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BM9_B_SAMB301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	5 / 12	LEU A 282 LEU A 286 GLU A 91 GLY A 119 ARG A 127	None	1.23A	2bm9B-4hdtA: undetectable	2bm9B-4hdtA: 21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BM9_D_SAMD301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	5 / 12	LEU A 282 LEU A 286 GLU A 91 GLY A 119 ARG A 127	None	1.18A	2bm9D-4hdtA: undetectable	2bm9D-4hdtA: 21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CPP_A_CAMA422_0 (CYTOCHROME P450-CAM)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 7	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.06A	2cppA-4hdtA: undetectable	2cppA-4hdtA: 19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GSS_A_EAAA0_1 (GLUTATHIONE S-TRANSFERASE P1-1)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 8	TYR A 92 VAL A 148 ILE A 73 GLY A 116	None	0.82A	2gssA-4hdtA: undetectable	2gssA-4hdtA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GSS_B_EAAB0_1 (GLUTATHIONE S-TRANSFERASE P1-1)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 8	TYR A 92 VAL A 148 ILE A 73 GLY A 116	None	0.82A	2gssB-4hdtA: undetectable	2gssB-4hdtA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2M56_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 5	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.07A	2m56A-4hdtA: undetectable	2m56A-4hdtA: 20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZAW_A_CAMA422_0 (CYTOCHROME P450-CAM)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 6	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.02A	2zawA-4hdtA: undetectable	2zawA-4hdtA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZUH_A_CAMA422_0 (CAMPHOR 5-MONOOXYGENASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 6	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.06A	2zuhA-4hdtA: undetectable	2zuhA-4hdtA: 20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZUI_A_CAMA422_0 (CAMPHOR 5-MONOOXYGENASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 6	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.05A	2zuiA-4hdtA: undetectable	2zuiA-4hdtA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A2Q_A_ACAA602_1 (6-AMINOHEXANOATE-CYC LIC-DIMER HYDROLASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 7	SER A 173 ALA A 217 ALA A 175 GLN A 223	None	0.86A	3a2qA-4hdtA: undetectable	3a2qA-4hdtA: 24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A51_B_VDYB6178_1 (VITAMIN D HYDROXYLASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	5 / 12	LEU A 55 ILE A 192 THR A 133 VAL A 113 LEU A 64	None	1.30A	3a51B-4hdtA: undetectable	3a51B-4hdtA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABM_P_CHDP1525_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 7	HIS A 246 TRP A 226 ASP A 238 TYR A 231	None	1.41A	3abmN-4hdtA: undetectable 3abmP-4hdtA: undetectable	3abmN-4hdtA: 21.28 3abmP-4hdtA: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FPJ_A_SAMA301_1 (PUTATIVE UNCHARACTERIZED PROTEIN)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 6	GLY A 143 THR A 269 GLU A 304 GLU A 326	None	1.09A	3fpjA-4hdtA: undetectable	3fpjA-4hdtA: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FWG_A_CAMA420_0 (CAMPHOR 5-MONOOXYGENASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 6	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.15A	3fwgA-4hdtA: undetectable	3fwgA-4hdtA: 20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GSS_A_EAAA212_1 (GLUTATHIONE S-TRANSFERASE P1-1)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 7	TYR A 92 VAL A 148 ILE A 73 GLY A 116	None	0.81A	3gssA-4hdtA: undetectable	3gssA-4hdtA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N9J_A_EAAA210_1 (GLUTATHIONE S-TRANSFERASE P)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 8	TYR A 92 VAL A 148 ILE A 73 GLY A 116	None	0.80A	3n9jA-4hdtA: undetectable	3n9jA-4hdtA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRH_E_CAME503_0 (CAMPHOR 5-MONOOXYGENASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 6	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.10A	3wrhE-4hdtA: undetectable	3wrhE-4hdtA: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRJ_E_CAME503_0 (CAMPHOR 5-MONOOXYGENASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 6	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.11A	3wrjE-4hdtA: undetectable	3wrjE-4hdtA: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A81_A_DXCA1161_0 (MAJOR POLLEN ALLERGEN BET V 1-A)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	5 / 12	ILE A 98 GLY A 119 VAL A 129 TYR A 105 LEU A 153	None	1.21A	4a81A-4hdtA: undetectable	4a81A-4hdtA: 18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G3R_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 6	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.11A	4g3rA-4hdtA: undetectable	4g3rA-4hdtA: 19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G3R_B_CAMB502_0 (CAMPHOR 5-MONOOXYGENASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 6	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.07A	4g3rB-4hdtA: undetectable	4g3rB-4hdtA: 19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	5 / 12	VAL A 126 ALA A 209 PHE A 195 LEU A 64 THR A 196	None	1.23A	4iaqA-4hdtA: undetectable	4iaqA-4hdtA: 22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KKY_X_CAMX503_0 (CAMPHOR 5-MONOOXYGENASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 6	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.05A	4kkyX-4hdtA: undetectable	4kkyX-4hdtA: 19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L49_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 5	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.07A	4l49A-4hdtA: undetectable	4l49A-4hdtA: 20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L4C_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 6	PHE A 172 LEU A 153 VAL A 118 VAL A 129	None	1.12A	4l4cA-4hdtA: undetectable	4l4cA-4hdtA: 20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L8F_D_MTXD301_1 (GAMMA-GLUTAMYL HYDROLASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	5 / 11	GLY A 119 GLY A 115 GLU A 91 TRP A 88 HIS A 123	None	1.18A	4l8fD-4hdtA: undetectable	4l8fD-4hdtA: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	5 / 12	LEU A 19 VAL A 8 LEU A 21 LEU A 30 THR A 31	None None None None ACT A 406 (-4.9A)	0.97A	4m2wA-4hdtA: undetectable	4m2wA-4hdtA: 21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R29_D_SAMD301_0 (UNCHARACTERIZED PROTEIN)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	5 / 12	GLY A 169 ILE A 112 ALA A 66 MET A 114 GLY A 115	None	1.03A	4r29D-4hdtA: undetectable	4r29D-4hdtA: 19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ECL_D_ILED602_0 (JASMONIC ACID-AMIDO SYNTHETASE JAR1)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	5 / 6	ILE A 108 ALA A 198 THR A 196 VAL A 199 VAL A 187	None	1.13A	5eclD-4hdtA: undetectable	5eclD-4hdtA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HHJ_A_GLYA403_0 (RETRON-TYPE REVERSE TRANSCRIPTASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 4	LEU A 282 LEU A 153 GLY A 150 GLU A 289	None	1.11A	5hhjA-4hdtA: undetectable	5hhjA-4hdtA: 22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JO9_A_SORA302_0 (RIBITOL 2-DEHYDROGENASE)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	5 / 12	SER A 29 LEU A 30 GLY A 68 VAL A 70 PHE A 87	None None None None ACT A 406 (-3.7A)	1.36A	5jo9A-4hdtA: undetectable	5jo9A-4hdtA: 25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L8D_B_ACTB601_0 (NICKEL-BINDING PERIPLASMIC PROTEIN)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	3 / 3	THR A 323 PRO A 263 ASP A 301	None	0.93A	5l8dB-4hdtA: undetectable	5l8dB-4hdtA: 23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MWU_B_ACTB601_0 (NICKEL-BINDING PERIPLASMIC PROTEIN)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	3 / 3	THR A 323 PRO A 263 ASP A 301	None	0.93A	5mwuB-4hdtA: undetectable	5mwuB-4hdtA: 23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGC_A_ACTA813_0 (GEPHYRIN)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	3 / 3	THR A 151 ALA A 276 LYS A 278	None	0.71A	6fgcA-4hdtA: undetectable	6fgcA-4hdtA: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGD_A_ACTA817_0 (GEPHYRIN)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	3 / 3	THR A 151 ALA A 276 LYS A 278	None	0.69A	6fgdA-4hdtA: undetectable	6fgdA-4hdtA: 24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMP_P_CHDP302_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	4hdt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Mycolicibacteriu m thermoresistibil e)	4 / 7	HIS A 246 TRP A 226 ASP A 238 TYR A 231	None	1.33A	6nmpN-4hdtA: undetectable 6nmpP-4hdtA: undetectable	6nmpN-4hdtA: 21.28 6nmpP-4hdtA: 21.10

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["11GS_A_EAAA211_1","GLUTATHIONE S-TRANSFERASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"TYR A  92;VAL A 148;ILE A  73;GLY A 116","None","0.82A","11gsA-4hdtA:undetectable","11gsA-4hdtA:19.33"],["1DZ4_A_CAMA502_0","CYTOCHROME P450-CAM","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.07A","1dz4A-4hdtA:undetectable","1dz4A-4hdtA:20.96"],["1DZ4_B_CAMB502_0","CYTOCHROME P450-CAM","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.07A","1dz4B-4hdtA:undetectable","1dz4B-4hdtA:20.96"],["1GM7_B_PNNB1577_0","PENICILLIN G ACYLASE ALPHA SUBUNIT;PENICILLIN G ACYLASE BETA SUBUNIT","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"SER A  29;SER A  76;ALA A  72;ILE A  73","None;None;ACT A 406 (-3.6A);None","1.07A","1gm7A-4hdtA:undetectable;1gm7B-4hdtA:undetectable","1gm7A-4hdtA:22.25;1gm7B-4hdtA:23.30"],["1KGL_A_RTLA175_0","CELLULAR RETINOL-BINDING PROTEIN TYPE I","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",5,"LEU A 282;TYR A 105;GLY A  99;ILE A  98;LEU A  64","None","1.21A","1kglA-4hdtA:undetectable","1kglA-4hdtA:16.91"],["1T87_A_CAMA1422_0","CYTOCHROME P450-CAM","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.03A","1t87A-4hdtA:undetectable","1t87A-4hdtA:19.86"],["1T88_B_CAMB2422_0","CYTOCHROME P450-CAM","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.07A","1t88B-4hdtA:undetectable","1t88B-4hdtA:19.86"],["1X70_B_715B801_2","DIPEPTIDYL PEPTIDASE IV","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",3,"PHE A 144;TYR A  92;TYR A 290","None","0.96A","1x70B-4hdtA:undetectable","1x70B-4hdtA:18.31"],["2BM9_B_SAMB301_0","CEPHALOSPORIN HYDROXYLASE CMCI","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",5,"LEU A 282;LEU A 286;GLU A  91;GLY A 119;ARG A 127","None","1.23A","2bm9B-4hdtA:undetectable","2bm9B-4hdtA:21.23"],["2BM9_D_SAMD301_0","CEPHALOSPORIN HYDROXYLASE CMCI","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",5,"LEU A 282;LEU A 286;GLU A  91;GLY A 119;ARG A 127","None","1.18A","2bm9D-4hdtA:undetectable","2bm9D-4hdtA:21.23"],["2CPP_A_CAMA422_0","CYTOCHROME P450-CAM","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.06A","2cppA-4hdtA:undetectable","2cppA-4hdtA:19.86"],["2GSS_A_EAAA0_1","GLUTATHIONE S-TRANSFERASE P1-1","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"TYR A  92;VAL A 148;ILE A  73;GLY A 116","None","0.82A","2gssA-4hdtA:undetectable","2gssA-4hdtA:19.33"],["2GSS_B_EAAB0_1","GLUTATHIONE S-TRANSFERASE P1-1","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"TYR A  92;VAL A 148;ILE A  73;GLY A 116","None","0.82A","2gssB-4hdtA:undetectable","2gssB-4hdtA:19.33"],["2M56_A_CAMA502_0","CAMPHOR 5-MONOOXYGENASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.07A","2m56A-4hdtA:undetectable","2m56A-4hdtA:20.05"],["2ZAW_A_CAMA422_0","CYTOCHROME P450-CAM","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.02A","2zawA-4hdtA:undetectable","2zawA-4hdtA:20.28"],["2ZUH_A_CAMA422_0","CAMPHOR 5-MONOOXYGENASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.06A","2zuhA-4hdtA:undetectable","2zuhA-4hdtA:20.51"],["2ZUI_A_CAMA422_0","CAMPHOR 5-MONOOXYGENASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.05A","2zuiA-4hdtA:undetectable","2zuiA-4hdtA:20.28"],["3A2Q_A_ACAA602_1","6-AMINOHEXANOATE-CYCLIC-DIMER HYDROLASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"SER A 173;ALA A 217;ALA A 175;GLN A 223","None","0.86A","3a2qA-4hdtA:undetectable","3a2qA-4hdtA:24.55"],["3A51_B_VDYB6178_1","VITAMIN D HYDROXYLASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",5,"LEU A  55;ILE A 192;THR A 133;VAL A 113;LEU A  64","None","1.30A","3a51B-4hdtA:undetectable","3a51B-4hdtA:22.12"],["3ABM_P_CHDP1525_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 3","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"HIS A 246;TRP A 226;ASP A 238;TYR A 231","None","1.41A","3abmN-4hdtA:undetectable;3abmP-4hdtA:undetectable","3abmN-4hdtA:21.28;3abmP-4hdtA:21.10"],["3FPJ_A_SAMA301_1","PUTATIVE UNCHARACTERIZED PROTEIN","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"GLY A 143;THR A 269;GLU A 304;GLU A 326","None","1.09A","3fpjA-4hdtA:undetectable","3fpjA-4hdtA:21.51"],["3FWG_A_CAMA420_0","CAMPHOR 5-MONOOXYGENASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.15A","3fwgA-4hdtA:undetectable","3fwgA-4hdtA:20.23"],["3GSS_A_EAAA212_1","GLUTATHIONE S-TRANSFERASE P1-1","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"TYR A  92;VAL A 148;ILE A  73;GLY A 116","None","0.81A","3gssA-4hdtA:undetectable","3gssA-4hdtA:19.33"],["3N9J_A_EAAA210_1","GLUTATHIONE S-TRANSFERASE P","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"TYR A  92;VAL A 148;ILE A  73;GLY A 116","None","0.80A","3n9jA-4hdtA:undetectable","3n9jA-4hdtA:19.33"],["3WRH_E_CAME503_0","CAMPHOR 5-MONOOXYGENASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.10A","3wrhE-4hdtA:undetectable","3wrhE-4hdtA:20.14"],["3WRJ_E_CAME503_0","CAMPHOR 5-MONOOXYGENASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.11A","3wrjE-4hdtA:undetectable","3wrjE-4hdtA:20.14"],["4A81_A_DXCA1161_0","MAJOR POLLEN ALLERGEN BET V 1-A","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",5,"ILE A  98;GLY A 119;VAL A 129;TYR A 105;LEU A 153","None","1.21A","4a81A-4hdtA:undetectable","4a81A-4hdtA:18.41"],["4G3R_A_CAMA502_0","CAMPHOR 5-MONOOXYGENASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.11A","4g3rA-4hdtA:undetectable","4g3rA-4hdtA:19.86"],["4G3R_B_CAMB502_0","CAMPHOR 5-MONOOXYGENASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.07A","4g3rB-4hdtA:undetectable","4g3rB-4hdtA:19.86"],["4IAQ_A_2GMA2001_1","CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",5,"VAL A 126;ALA A 209;PHE A 195;LEU A  64;THR A 196","None","1.23A","4iaqA-4hdtA:undetectable","4iaqA-4hdtA:22.66"],["4KKY_X_CAMX503_0","CAMPHOR 5-MONOOXYGENASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.05A","4kkyX-4hdtA:undetectable","4kkyX-4hdtA:19.68"],["4L49_A_CAMA502_0","CAMPHOR 5-MONOOXYGENASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.07A","4l49A-4hdtA:undetectable","4l49A-4hdtA:20.28"],["4L4C_A_CAMA502_0","CAMPHOR 5-MONOOXYGENASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"PHE A 172;LEU A 153;VAL A 118;VAL A 129","None","1.12A","4l4cA-4hdtA:undetectable","4l4cA-4hdtA:20.51"],["4L8F_D_MTXD301_1","GAMMA-GLUTAMYL HYDROLASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",5,"GLY A 119;GLY A 115;GLU A  91;TRP A  88;HIS A 123","None","1.18A","4l8fD-4hdtA:undetectable","4l8fD-4hdtA:21.51"],["4M2W_A_ETSA302_1","CARBONIC ANHYDRASE 2","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",5,"LEU A  19;VAL A   8;LEU A  21;LEU A  30;THR A  31","None;None;None;None;ACT A 406 (-4.9A)","0.97A","4m2wA-4hdtA:undetectable","4m2wA-4hdtA:21.49"],["4R29_D_SAMD301_0","UNCHARACTERIZED PROTEIN","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",5,"GLY A 169;ILE A 112;ALA A  66;MET A 114;GLY A 115","None","1.03A","4r29D-4hdtA:undetectable","4r29D-4hdtA:19.83"],["5ECL_D_ILED602_0","JASMONIC ACID-AMIDO SYNTHETASE JAR1","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",5,"ILE A 108;ALA A 198;THR A 196;VAL A 199;VAL A 187","None","1.13A","5eclD-4hdtA:undetectable","5eclD-4hdtA:21.60"],["5HHJ_A_GLYA403_0","RETRON-TYPE REVERSE TRANSCRIPTASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"LEU A 282;LEU A 153;GLY A 150;GLU A 289","None","1.11A","5hhjA-4hdtA:undetectable","5hhjA-4hdtA:22.40"],["5JO9_A_SORA302_0","RIBITOL 2-DEHYDROGENASE","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",5,"SER A  29;LEU A  30;GLY A  68;VAL A  70;PHE A  87","None;None;None;None;ACT A 406 (-3.7A)","1.36A","5jo9A-4hdtA:undetectable","5jo9A-4hdtA:25.08"],["5L8D_B_ACTB601_0","NICKEL-BINDING PERIPLASMIC PROTEIN","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",3,"THR A 323;PRO A 263;ASP A 301","None","0.93A","5l8dB-4hdtA:undetectable","5l8dB-4hdtA:23.62"],["5MWU_B_ACTB601_0","NICKEL-BINDING PERIPLASMIC PROTEIN","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",3,"THR A 323;PRO A 263;ASP A 301","None","0.93A","5mwuB-4hdtA:undetectable","5mwuB-4hdtA:23.62"],["6FGC_A_ACTA813_0","GEPHYRIN","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",3,"THR A 151;ALA A 276;LYS A 278","None","0.71A","6fgcA-4hdtA:undetectable","6fgcA-4hdtA:24.17"],["6FGD_A_ACTA817_0","GEPHYRIN","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",3,"THR A 151;ALA A 276;LYS A 278","None","0.69A","6fgdA-4hdtA:undetectable","6fgdA-4hdtA:24.17"],["6NMP_P_CHDP302_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 3","4hdt","3-HYDROXYISOBUTYRYL-COA HYDROLASE","Mycolicibacterium thermoresistibile",4,"HIS A 246;TRP A 226;ASP A 238;TYR A 231","None","1.33A","6nmpN-4hdtA:undetectable;6nmpP-4hdtA:undetectable","6nmpN-4hdtA:21.28;6nmpP-4hdtA:21.10"]]