SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4he4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A69_C_RPTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)		 4he4 YELLOW FLUORESCENT
PROTEIN
(Phialidium
sp.
SL-2003) 		5 / 11 GLN A  69
PHE A  71
SER A 161
PRO A 196
ILE A 150
 CRO  A  65 ( 4.2A)
None
None
None
None
 1.46A 2a69C-4he4A:
0.0
2a69F-4he4A:
undetectable		 2a69C-4he4A:
11.88
2a69F-4he4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 4he4 YELLOW FLUORESCENT
PROTEIN
(Phialidium
sp.
SL-2003) 		4 / 5 ILE A 165
THR A  59
SER A  58
PHE A 143
 None
None
None
CRO  A  65 ( 4.7A)
 0.97A 3snfA-4he4A:
undetectable		 3snfA-4he4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 4he4 YELLOW FLUORESCENT
PROTEIN
(Phialidium
sp.
SL-2003) 		4 / 5 LEU A 207
TRP A  57
ILE A  29
ASN A 119
 None
None
None
CRO  A  65 ( 4.0A)
 1.40A 4i00A-4he4A:
undetectable		 4i00A-4he4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4he4 YELLOW FLUORESCENT
PROTEIN
(Phialidium
sp.
SL-2003) 		4 / 6 ASN A 119
GLU A 113
TYR A 118
GLU A  17
 CRO  A  65 ( 4.0A)
None
None
None
 1.34A 4mi4A-4he4A:
undetectable		 4mi4A-4he4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4he4 YELLOW FLUORESCENT
PROTEIN
(Phialidium
sp.
SL-2003) 		4 / 7 ASN A 119
GLU A 113
TYR A 118
GLU A  17
 CRO  A  65 ( 4.0A)
None
None
None
 1.32A 4mj8C-4he4A:
undetectable		 4mj8C-4he4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4he4 YELLOW FLUORESCENT
PROTEIN
(Phialidium
sp.
SL-2003) 		5 / 12 GLY A 127
GLY A 102
PHE A  98
GLY A 125
VAL A  22
 None
 0.96A 4o3fA-4he4A:
undetectable		 4o3fA-4he4A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4he4 YELLOW FLUORESCENT
PROTEIN
(Phialidium
sp.
SL-2003) 		4 / 7 ASN A 119
GLU A 113
TYR A 118
GLU A  17
 CRO  A  65 ( 4.0A)
None
None
None
 1.27A 4r87I-4he4A:
undetectable		 4r87I-4he4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 4he4 YELLOW FLUORESCENT
PROTEIN
(Phialidium
sp.
SL-2003) 		5 / 12 THR A  59
SER A  58
GLY A 136
PHE A 128
GLY A 100
 None
 1.45A 4uinH-4he4A:
undetectable
4uinL-4he4A:
undetectable		 4uinH-4he4A:
23.64
4uinL-4he4A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4he4 YELLOW FLUORESCENT
PROTEIN
(Phialidium
sp.
SL-2003) 		4 / 4 GLY A  40
VAL A  42
PHE A 112
ILE A  12
 None
 0.86A 4xv2B-4he4A:
undetectable		 4xv2B-4he4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CLT_B_ACRB1000_1
(1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME)		 4he4 YELLOW FLUORESCENT
PROTEIN
(Phialidium
sp.
SL-2003) 		5 / 10 ASN A 114
GLU A 113
GLY A  31
GLU A  17
ARG A 120
 None
 1.47A 5cltB-4he4A:
0.0		 5cltB-4he4A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4he4 YELLOW FLUORESCENT
PROTEIN
(Phialidium
sp.
SL-2003) 		3 / 3 ASN A 119
TYR A  14
CYH A  70
 CRO  A  65 ( 4.0A)
None
None
 0.77A 5lsuB-4he4A:
undetectable		 5lsuB-4he4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 4he4 YELLOW FLUORESCENT
PROTEIN
(Phialidium
sp.
SL-2003) 		4 / 8 ALA A 179
VAL A 121
GLN A  92
HIS A 146
 None
None
CRO  A  65 ( 3.7A)
CRO  A  65 ( 3.8A)
 1.03A 5nu7A-4he4A:
undetectable		 5nu7A-4he4A:
21.12